2004 Fiscal Year Final Research Report Summary
Comparative investigation of tolerance trait of anticancer drugs in primary and metastatic lesions of gastrointestinal carcinoma
| Project/Area Number |
14571235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
OGAWA Kenji Tokyo Women's Medical University, Department of Surgery, Professor, 医学部, 教授 (20075386)
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| Co-Investigator(Kenkyū-buntansha) |
KATSUBE Takao Tokyo Women's Medical University, Department of Surgery, Associate Professor, 医学部, 講師 (40224472)
KONNO Soichi Tokyo Women's Medical University, Department of Surgery, Research Associate, 医学部, 助手 (10234957)
NITTA Yasutaka Tohoku University, School of Dentistry, Research Associate, 歯学部, 助手 (80250794)
TAKEBAYASHI Yuji Fukushima Medical University, School of Medicine, Department of Surgery, Associate Professor, 医学部, 講師 (70321982)
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| Project Period (FY) |
2002 – 2004
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| Keywords | Cancer Chemotherapy / Metastasis / Embrane Transporter / DNA repair / Angiogenesis / GI tract carcinoma |
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| Research Abstract |
First, the expression levels of the target molecules for cancer chemotherapy such as drug transporters (ATP7B, MRP,2), DNA repair molecules (XPG, XPF) and the targets for FU such as TP, DPD, TS were examined by RT-PCR and immunohistochemical analysis. The expression levels of TP and TS were different between primary and metastatic lesions among the examined molecules. Next, using the transfectants of TS or TP, the enhancement of the expression levels of these molecules were examined in animal models. Unfortunately, the enhancement of these molecules was not obtained.
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Research Products
(12 results)
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[Journal Article] Expression of copper-transporting P-type adenosine triphosphatase (ATP7B) in human hepatocellular carcinoma2004
Author(s)
Ogawa K., Sugeno H., Takebayashi Y., Higashimoto M., Ogura Y., Shibukawa G., Kanzaki A., Terada K., Sugiyama T., Watanabe K., Katoh R., Nitta Y, Fukushima T., Koyama Y., Inoue N., Sekikawa K., Sato Y., Takenoshita S.
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Journal Title
Anticancer Res. 24
Pages: 1045-1048
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Prognostic value of the Cu-transporting ATPase in overian carcinoma patients receiving cisplatin-based chemotherapy.2004
Author(s)
Ogawa K., Nakayama K., Kanzaki A., Terada K., Mutoh M., Sugiyama T., Takenoshita S., Itoh K., Yaegashi N., Miyazaki K., Neamati N., Takebayashi Y.
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Journal Title
Clin Cancer Res. 10(15)
Pages: 2804-2811
Description
「研究成果報告書概要(欧文)」より
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