2005 Fiscal Year Final Research Report Summary
RESEARCH FOR PSEUDOCAPSULE FORMATION OF METASTATIC LIVER TUMORS
| Project/Area Number |
14571250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | JAPANESE FOUNDATION FOR CANCER |
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Principal Investigator |
YAMAMOTO Junji JAPANESE FOUNDATION FOR CANCER, CANCER INSTITUTE, 癌研究所, 研究員 (40342654)
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| Co-Investigator(Kenkyū-buntansha) |
SAIURA Akio JAPANESE FOUNDATION FOR CANCER, CANCER INSTITUTE, 癌研究所, 研究員 (70345221)
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| Project Period (FY) |
2002 – 2005
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| Keywords | colorectal liver metastasis / PSEUDOCAPSULE / DNA microarray / pathology |
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| Research Abstract |
PURPOSE : To clarify the cause and pathogenesis of pseudocapsule around the liver tumor, liver metastatic tumor from colorectal cancer were analyzed pathomorphologically and by DNA microarray. MATERIAL AND METHODS : 1.Harvesting of tissue RNA and DNA microarray analysis From the frozen specimen of resected liver tumor from colorectal cancer, total RNA was collected by Laser microdissection from cancer tissue near the pseudocapsule and noncancerous liver parenchyma. Five patients whose tumor had thick capsule and the other five whose tumor showed no capsule were selected for analysis, respectively. For analysis, GeneSpring and d-Chip software was used. RESULTS : From the analysis using GeneSpring software the genes possibly related to pseudocapsule formation were more frequently found in the cancer tissue than in the normal tissue. The d-Chip picked out 47 genes which showed the different level of expression between cancer and noncancerous tissues.
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[Journal Article] Surgical treatment of intraductal papillary-mucinous tumor (IPMT) of the pancreas : operative indications based on surgico-pathologic study focusing on invasive carcinoma derived from IPMT.2003
Author(s)
Seki M, Yanagisawa A, Ohta H, Ninomiya Y, Sakamoto Y, Yamamoto J, Yamaguchi T, Ninomiya E, Takano K, Aruga A, Yamada K, Sasaki K, Kato Y.
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Journal Title
J Hepatobiliary Pancreat Surg 10
Pages: 147-155
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Strategies for surgical treatment of gallbladder carcinoma based on information available before resection.2003
Author(s)
Kokudo N, Makuuchi M, Natori T, Sakamoto Y, Yamamoto J, Seki M, Noie T, Sugawara Y, Imamura H, Asahara S, Ikari T.
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Journal Title
Arch Surg 138
Pages: 741-750
Description
「研究成果報告書概要(欧文)」より
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