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2003 Fiscal Year Final Research Report Summary

Investigation for the machamism of hipocampal damage and itsu protection using in vivo and in vitro positron emission tomography study of human brain.

Research Project

Project/Area Number 14571301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NARIAI Tadashi  Tokyo Medical and Dental University, Medical Hospital, Lecturer, 医学部附属病院, 講師 (00228090)

Co-Investigator(Kenkyū-buntansha) SASAKI Toru  Tokyo Metropolitan Institute of Gerontology, Staff researcher, ポジトロン医学研究施設, 研究員 (30158927)
MAEHARA Taketoshi  Tokyo Medical and Dental University, Medical Hospital, Lecturer, 医学部附属病院, 講師 (40211560)
Project Period (FY) 2002 – 2003
Keywordsadenosine receptor / hippocampus / positron emission tomography / temporal lobe epilepsy / F-18 FDG / cerebral glucose metabolism / opitical imaging / C11 MPDX
Research Abstract

1) All the patients with intractable temporal lobe epilepsy (TLE) who were operated on in Department of Neurosurgery, Tokyo Medical and Dental University underxvent measurement of cerebral metabolic rate of glucose and the binding potential of central benzodiazepine receptors with positron emission tomography (PET). A new project to image the cerebral adenosine Al receptor using newly developed tracer C-il MPDX and PET in patients with TLE.
2) In this new project, we revealed that the adenosine receptor decreased in the fugiform gyrus of focus side and increased in the frontal cortex of focus side. This new finding is now prepared for a paper and a presentation in the international meeting.
3) Investitaion to measure the cerebral metabolism of human cortical slice which were obtained in 10 patients with TLE was completed. In this analysis, ~ve revealed that the metabolism in the kalium obtained media corresponded with the metabolism in the preoperative condition measured with PET but that in the control media did not. It suggested that the cerebral metaboliosm in so to speak resting condition is the state that neuron, is working with full neuronal input. This finding is now repared for a paper and a presentation in the international meeting.
4) We performed the comparative experiment between the metabolism and neuronal electrical activity in human slice. The latter was performed using optical imaging technique. This experiment revealed that the metabolism is induce by potassium stimulation even in the condition where neuronal conduction is not established. This finding suggest the different behavior of neuron in the slice condition.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Nariai T, Shimada Y, Ishiwata K, Nagaoka T, Shimada J, Kuroiwa T, Ono KI, Ohno K, Hirakawa K, Senda M: "PET imaging of adenosine a(1) receptors with (11)C-MPDX as an indicator of severe cerebral ischemic insult."J Nucl Med. 44. 1839-1844 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato K, Nariai T, Ohno K et al.: "Intraoperative Intrisic Optical Imaging og Neruonal Activity from Subdivisions of the Human Primary Somatosensory Cortex."Cereb Cortex. 12. 269-280 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maehara T, Nariai T, Arai N, Kawai K, Shimizu H, Ishii K, Ishiwata K, Ohno K: "Usefulness of [11C] Methionine PET in the Diagnosis of Dysembryoplastic Neuroepithelial Tumor with Temporal Lobe Epilepsy."Epilesia. 45. 41-45 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki T, Ishiwata K, Murata T, Senda M.: "Demonstration of competition between endogenous dopamine and [11c]raclopride binding in in vitro brain slices using a dynamic autoradiography technique."Synapse. 44. 42-50 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimada Y, Kiyosawa M, Mariai T, Oda K, Toyama H, Ono K, Senda M, Ishiawata K.: "Quantitative in vivo measurement of central benzodiazepine receptors in the brain of cats by use of positron-emission tomography and [11c]flumazenil"Am J Vet Res. 64. 999-1002 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sasaki T, Kawamura K, Tanaka Y, Ando S, Senda M.: "Assessment of choline uptake for the synthesis and release of acetylcholine in brain slices by a dynamic autoradiographic technique using [11c]choline."Brain Res Brain Res Protoc. 10. 1-11 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nariai T, Ohno K, et al.: "ntrinsic optical recording of somatrosensory responses in the human cerebral cortex during brain tumor surgery in Brain Activation and CBF Control"Tomita M, Kanno I, E H, eds. Brain activation and CBF control. Amsterdam : Elsevier. 243-248 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nariai T, Shimada Y, Ishiwata K, Nagaoka T, Shimada J, Kuroiwa T, Ono KI, Ohno K, Hirakawa K, Senda M: "PET imaging of adenosine a(1) receptors with (11)C-MPDX as an indicator of severe cerebral isehemic insult."J Nuci Med. 44. 1839-1844 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maehara T, Nariai T, Arai N, Kawai K, Shimizu H, Ishii K, Ishiwata K, Ohno K: "Usefulness of [11C] Methionine PET in the Diagnosis of Dysembryoplastic Neuroepithelial Tumor with Temporal Lobe Epilepsy"Epilepsia. 45. 41-45 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimada Y, Kiyosawa M, Nariai T, Oda K, Toyama H, Ono K, Senda M, Ishiwata K.: "Quantitative in vivo measurement of central benzodiazepine receptors in the brain of cats by use of positron-emission tomography and [11c]flumazenil."Am J Vet Res. 64. 999-1002 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, K., T.Nariai, S.Sasaki, I.Yazawa, H.Mochida, N.Miyakawa, Y.Momose-Sato, K.Kamino, Y.Ohta, K.Hirakawa, K.Ohno: "Intraoperative: Intrinsic Optical Imaging of Neuronal Activity from Subdivisions of the Human Primary Somatosensory Cortex."Cereb Cortex. 12. 269-280 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki T, Ishiwata K, Murata T, Senda M.: "Demonstration of competition between endogenous dopamine and [11c]raclopride binding in in vitro brain slices using a dynamic autoradiography technique"Synapse. 44. 42-50 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sasaki T, Kawamura K, Tanaka Y, Ando S, Senda M.: "Assessment of choline uptake for the synthesis and release of acetyicholine in brain slices by a dynamic autoradiographic technique using [11c] choline"Brain Res Brain Res Protoc. 10. 1-11 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishiwata K, Nariai T, et al.: "Preclinical studies on [11c]mpdx for mapping adenosine al receptors by positron emission tomography."Ann Nucl Med. 16. 377-382 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nariai, T, Ohta, Y, Hirakawa, K, Sato, K, Yazawa, I, Sasaki, S, Kamino, K, Ohno, K.: "Intrinsic Optical recording of somatosensory responses in the human cerebral cortex during brain tumor surgery."(Tomita M, Kanno I, E H, eds.) Brain activation and CBF control.(Amsterdam: Elsevier). 243-248 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nariai T, Shimada Y, Ishiwata K, Nagaoka T, Shimada J, Kuroiwa K, Ono K, Hirakawa K, Senda M, Ohno K.: "PET neuroreceptor imaging as predictor of severe cerebral ischemic insult"Acta Neurochir. 86(suppl). 47-50 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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