2003 Fiscal Year Final Research Report Summary
Biological Response of the Arterial Wall to Carotid Artery Stenting
| Project/Area Number |
14571308
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Mie University |
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Principal Investigator |
MATSUSHIMA Satoshi Mie University, Faculty of Medicine, Assistant Professor, 医学部, 講師 (50252367)
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| Project Period (FY) |
2002 – 2003
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| Keywords | carotid artery stenosis / stenting / restenosis / vascular endothelial cells / atheroma / atherosclerosis / endovascular treatment |
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| Research Abstract |
Stenting of carotid arteries has emerged as an alternative to endarterectomy for the treatment of carotid artery diseases. This procedure has become safe, with a high success rate, following the introduction of protection devices prevent distal embolism, although in-stent restenosis is still a major clinical issue after stenting, and occurs in 4% to 8% of cases. Several cellular and molecular events may develop sequentially after vascular injury caused by balloon angioplasty and stenting. However, there are few reports about the biological response of the arterial wall to carotid artery stenting. In the present study, we evaluated the local pathological changes in the carotid arteries of hypercholesterolemic rabbits.
In the result, we made the excellent rabbit model of atherosclerosis by endothelial injuries of the common carotid arteries using a balloon catheter following to receive chow containing 1 % cholesterol. In the atherosclerosis rabbit model, tenascin-C (Tn-C) was expressed in the inner side of the carotid arterial wall. The expression of Tn-C was inhibited by angiotensin II receptor blocker. This finding suggest that the expression of Tn-C is regulated by angiotensin and Tn-C may be involved in the atherosclerotic change of the carotid artery.
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