2004 Fiscal Year Final Research Report Summary
Effect of local hypothermia in spinal cord injury
| Project/Area Number |
14571326
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Nagoya City University |
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Principal Investigator |
MOTOKI Tanikawa Nagoya City University, Graduate School of Medical sciences, Research Associate, 大学院・医学研究科, 助手 (20343402)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Kazuo Nagoya City University, Graduate School of Medical Sciences, Professor, 大学院・医学研究科, 教授 (90150341)
MASE Mitsuhito Nagoya City University, Graduate School of Medical Sciences, Associate Professor, 大学院・医学研究科, 助教授 (60238920)
AIHARA Noritaka Nagoya City University, Graduate School of Medical Sciences, Assistant Professor, 大学院・医学研究科, 講師 (00264739)
YAMAMOTO Kenichi Nagoya City University, Graduate School of Medical Sciences, Research Associate, 大学院・医学研究科, 助手 (80372837)
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| Project Period (FY) |
2002 – 2004
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| Keywords | spinal cord injury / anoptosis / hypothermia |
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| Research Abstract |
Recent evidence has suggested apoptosis as an important component of degenerative processes after spinal cord injury (SCI). We tried to confirm this relationship, and to apply the hypothermia therapy, that included systemic method by using specific blanket, and local method by intrathecal-administration of cold saline. However, we could not get any significant results from each experiment, because it might be difficult to keep body temperature of rats for a certain period. We tried to improve those methods, yet we could not do that in this term.. On the other hand, we clarified that expressions of SMIT and myelincephalon specific protease (MSP) increased around injured site. Those molecules might be related to apoptosis and secondary injury of neuronal tissue. We think that there will be some possibility for neuronal protection from secondary injury by further experiments, such as inhibition of functions of those molecules
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