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2004 Fiscal Year Final Research Report Summary

Regulation of Bone Formation by Mechanical Stress

Research Project

Project/Area Number 14571374
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

IMAI Shinji  Shiga University of Medical Science, Faculty of Medicine, Associate Professor, 医学部, 助教授 (90283556)

Co-Investigator(Kenkyū-buntansha) MATSUSUE Yoshitaka  Shiga University of Medical Science, Faculty of Medicine, Professor, 医学部, 教授 (30209548)
Project Period (FY) 2002 – 2004
Keywordsosteogenesis / osteoblast / mechanical stress / HB-GAM / knockout mice
Research Abstract

The purpose of the current project is to provide a scientific basis for our working hypothesis that HB-GAM acts as the putative mediator for the mechanical adaptation of bone formation. Using HB-GAM knockout mice, we have gained below-listed results.
1.HB-GAM knockout mice ware born without apparent patterning defects. However, late-emerging growth retardation of the long bone becomes evident.
2.Detailed bone morphometry revealed that bone formation rate is significantly reduced in the HB-GAM null mutant mice.
3.Although bone resorption rate is reduced in the HB-GAM null mutant mice, it is not as much as bone formation rate. Thus, osteopenia of HB-GAM null mutant mice results mostly from low bone formation rate.
4.Immobilization by the resection of sciatic nerve reduces mechanical loads to the long bones and lowers bone formatin rate. The reduction rate of bone formation by immobilization is as much as that occurred in the HB-GAM null mutant mice.
5.Increase of mechanical stress by physical exercise enhances bone formation activities. However, exercise-associated increase of bone formation was absent from the HB-GAM null mutant mice.
6.These results were compatible with our hypothesis that HB-GAM acts as the putative mediator for the mechanical adaptation of bone formation.

  • Research Products

    (8 results)

All 2005 2004

All Journal Article (7 results) Book (1 results)

  • [Journal Article] Posttraumatic Recurrent Dislocation of Extensor Pollicis Brevis Tendon over the Metacarpophalangeal Joint2005

    • Author(s)
      Imai S, Kikuchi K, Matsusue Y
    • Journal Title

      J Hand Surg (Am) 30

      Pages: 147-150

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Nociceptive pathway and pathology of low back pain2005

    • Author(s)
      Imai S
    • Journal Title

      Current Rheumatology Reviews 1

      Pages: 167-176

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Posttraumatic Recurrent Dislocation of Extensor Pollicis Brevis Tendon over the Metacarpophalangeal Joint.2005

    • Author(s)
      Imai S, Kikuchi K, Matsusue Y.
    • Journal Title

      J Hand Surg. 30A

      Pages: 147-150

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Nociceptive pathway and pathology of low back pain.2005

    • Author(s)
      Imai S.
    • Journal Title

      Current Rheumatology Reviews 1

      Pages: 167-176

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Spontaneous Rupture of the Flexor Digitorum Profundus and Sublimus of the Index finger and the Flexor Pollicis Longus Without Labor-associated Tendon Loading2004

    • Author(s)
      Imai S, Kubo S, Kikuchi K, Ueba H, Matsusue Y.
    • Journal Title

      J Hand Surg (Am) 29

      Pages: 587-590

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Spontaneous Rupture of the Flexor Digitorum Profundus and Sublimus of the Index finger and the Flexor Pollicis Longus Without Labor-associated Tendon Loading.2004

    • Author(s)
      Imai S, Kubo S, Kikuchi K, Ueba H, Matsusue Y.
    • Journal Title

      J Hand Surg. 29A

      Pages: 587-590

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Chondrocyte differentiation and cartilage repair.2004

    • Author(s)
      Kubo M, Imai S.
    • Journal Title

      Recent Research Development in Cell Biology. Transworld Research Network(Ed : S.G.Pandalai)

      Pages: 155-175

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] Recent Research Development in Cell Biology.2004

    • Author(s)
      Kubo M, Imai S.
    • Total Pages
      155-175
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2006-07-11  

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