2003 Fiscal Year Final Research Report Summary
Basic Study for the development of artificial hip joint -Development of new bone-prosthesis interface -
| Project/Area Number |
14571404
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
YANAGIMOTO Shigeru Keio University, School of Medicine, Assistant Professor, 医学部, 講師 (60166551)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Yoshinari Keio University, School of Medicine, Assistant, 医学部, 助手 (10296642)
HOTTA Hiraku Keio University, School of Medicine, Assistant, 医学部, 助手 (50255494)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Artificial Hip Joint / Interface / Surface Structure / Lone-term Fixation / Hydroxyapatite Coating |
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| Research Abstract |
A new type of porous coating for hip prostheses called "multilayered mesh" was tested under weight bearing conditions. The hip stems of hydroxyapatite (HA)-coated multilayered mesh and conventional beads were implanted into canine right hips, and animals were killed 3, 6 and 10 weeks and 6 and 12 months after implantation. Shear strength between the implant and the bone was evaluated by the push-out test. Bone ingrowth was calculated from backscattered electron imaging-scanning electron microscopy (BEI-SEM) images of transverse sections. Toluidine blue stained sections and the BEI-SEM images were evaluated histologically. The mean push-out strength of the HA-coated multilayered mesh samples was greater than that of the beads coated samples every time tested, and the HA-coated multilayered mesh implants had significantly stronger push-out strength at 3 and 6 weeks (p<0.05). The strength of the HA-coated multilayered mesh implants was even greater at 6 and 12 months, whereas the strength
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of the beads-coated samples decreased. The HA-coated multilayered mesh implants showed significantly higher percentages of bone ingrowth than the beads coated implants every time tested, except at 6 months (p<0.05). At 6 and 12 months, the bone ingrowth data for the HA-coated multilayered mesh implants increased, whereas it decreased for the beads coated implants. The new bone formation had reached the bottom of the porous area of the HA-coated multilayered mesh surface by 3 weeks, but not had reached the bottom of the conventional beads surface. At 6 and 12 months, the smaller pores of the bead surface stopped the thickening of trabecular bane, and at 12 months, the break sites were at the bone-implant interface of the bead surface, whereas they were on the bone side of the HA-coated multilayered mesh surface. The difference between the break sites was significant at 12 months (p<0.05). The HA-coated multilayered mesh stem provided faster, stronger, and more durable osseointegration than the conventional bead stem. Less
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