2003 Fiscal Year Final Research Report Summary

Effect of inhalational anesthetics for HIF-α mRNA expression in the Septic shock

Research Project

Project/Area Number	14571472
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Anesthesiology/Resuscitation studies
Research Institution	Nippon Medical School
Principal Investigator	ONODERA Hidetaka Nippon Medical School, Deppartment of Anesthesiology, assistant, 医学部, 助手 (40328787)
Project Period (FY)	2002 – 2003
Keywords	c-fos / Propofol / midline thalamic nuculei / in situ hybridization
Research Abstract	We investigate intravenous anesthetic Propofol (2,6-di-isopropylp h enol) suppress the induction of c-fos mRNA in the rat neocortex which expression begin to increase 2 hours before the dark period and remained elevated following the dark period in a normal rat. Simultaneously, administration of Propofol induce the expression of c-fos mRNA in the midline thalamic nuclei which is also activated by some benzodiazepine narcotic drugs. These indicate that narcotic action of Propofol exhibit via activation of midline thalamic nuclei. We also investigate that c-fos mRNA expression in the olivary nucleus in the medulla and in cereberal cortex in administration of Propofol in the rate of 20mg/kg and 30mg/kg. Rate of 10mg/kg do not induce the c-fos mRNA in these nucleus and cortex suggest that comparative high dose administration of propofol have some affects for these nucleus.

(4 results)