2003 Fiscal Year Final Research Report Summary
the role of bone marrow transplantation for the ischemic renal injury and regeneration
| Project/Area Number |
14571509
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
KOGURE Michihiko Fukushima Medical University, Department of Surgery, Assistant professor, 医学部, 講師 (90264548)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Takuro Fukushima Medical University, Department of Surgery, Assistant, 医学部, 助手 (20305361)
TERASHIMA Masanori Fukushima Medical University, Department of Surgery, Associate Professor, 医学部, 助教授 (40197794)
GOTOH Mitsukazu Fukushima Medical University, Department of Surgery, Professor, 医学部, 教授 (50162160)
HOSHINO Yutaka Fukushima Medical University, Department of Surgery, Assistant, 医学部, 助手 (30295414)
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| Project Period (FY) |
2002 – 2003
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| Keywords | green mouse / bone marrow transplantation / renal injury and regeneration |
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| Research Abstract |
Bone marrow cells from mice transgenic for green fluorescence protein (GFP) were transplanted to the B6 mice irradiated X-ray at a dose of 12Gy to make chimeric mice. Two weeks after BMT, chimeric animals were divided into 3 groups as followed : nephrectomy, ischemia-reperfusion induced renal injury, and normal control group. These chimeric animals were sacrificed at 1 week GFP positive cell were detected at the renal parenchyma and glomerular endothelial cells without other groups. We suggest that glomerular endothelial cells might be replaced with these GFP positive cells at the damaged kidney.
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