A prospective study of prediction of preterm labor and dynamics of cytokine network in a onset of preterm labor

2004 Fiscal Year Final Research Report Summary

• Project/Area Number: 14571580
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Kitasato University
• Principal Investigator: TANI Akihiro KITASATO University, School of Medicine, Assistant professor, 医学部, 講師 (50207164)
• Co-Investigator(Kenkyū-buntansha): KANAI Yuji KITASATO University, School of Medicine, Research Associate, 医学部, 助手 (00306557) ; KIKUCHI Shinzo KITASATO University, School of Medicine, Research Associate, 医学部, 助手 (00337982) ; IKEDA Yasuhiro KITASATO University, School of Medicine, Research Associate, 医学部, 助手 (20327430)
• Project Period (FY): 2002 – 2004
• Keywords: cervical cerclage / IL1β / IL6 / IL8 / TNFα / preterm labor / risk of preterm labor / cervical mucus

Research Abstract

We measured inflammatory cytokines and their receptors or receptor antagonist of the vaginal discharge and cervical mucus as prospective study for the purpose of preterm labor prediction, for the cases that antenatal visit from 22 weeks to 24 weeks of gentational age, cervical incompetence was doubted in past pregnant history and cervical length shortening, after informed consent from patients. Results : 1) The number of the measurement cases were 2462, but the subject cases that no maternal and fetal complications, gestational age was accurate were 1705 cases. 2) It was thought that there was a little benefit of IL1β, IL8, TNFα, IL10, GM-CSF about a preterm labor onset prediction until 34 weeks of gestation statistically. But it is very likely that it is activated for the cytokines networks by there having been availability IL1 receptor antagonist, TNR soluble receptor I and II as erasing system of cytokines. 3) It was significantly benefit of cervical mucus for PTL prediction statistically when we compared cervical mucus with vaginal discharge. Each odds ratio in the cervical mucus which was effective for an PTL onset prediction ; IL1 receptor antagonist (Odds:) 1.95;95%C.I. 1.19-3.20;p<0.012), IL 6 (Odds:) 2.24;95%C.I. 1.19-4.19; p<0.022), TNR soluble receptor I (Odds:1.96;95%C.I. 1.11-3.45;p<0.03) and II (Odds : 2.06;95%C.I. 1.25-3.4;p<0.008). There was availability statistically, but there was a little availability from an aspect of cost benefit, as screening to PTL of all cases. On the other hand, it seems that was demonsterated availability for PTL prediction of the cases of cervical length shortening and high risk of PTL.

Research Products

• [Journal Article] 頸管縫縮術は有害か? -頸管縫縮術の頸管粘液中のサイトカイン濃度とその予後の検討 (2003)
  • Author(s): 菊地 信三
  • Journal Title: 日本産科婦人科学会雑誌 第55巻第2号 Pages: 234
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 緊急あるいは予防的頸管縫縮術の有効性と有害性 特に感染の有無の影響 (2003)
  • Author(s): 谷 昭博
  • Journal Title: 産婦人科の世界 55-7 Pages: 811-816
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Is cervical cerclage harmful or effective? The cytokines in cervical mucus measurement and the outcome in cases of cervical cerclage. (2003)
  • Author(s): Kikuchi, S., Tani, A., Saitoh, M., Yoshimura, C., Kanai Y., Mochizuki, J., Migishima, F., Saitoh, K., Amano, K., Nishijima, M.
  • Journal Title: Nihon Sanka Fujinka gakkaizasshi 55(2)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The efficacy and hazardness of emergency or preventive cervical cerclage. The influence of infectious presence. (2003)
  • Author(s): Tani, A., Kikuchi, S., Ikeda, Y., Imamura, Y., Kanai, Y., Mochizuki, J., Amamno, K., Nishijima, M.
  • Journal Title: Sanfujinka no Sekai 55(7) Pages: 811-816
  • Description: 「研究成果報告書概要(欧文)」より