2004 Fiscal Year Final Research Report Summary
THE INVERACTION OF VEGF, ANGIOPOIETIN, AND HYPOXIA IN ANGIOGENESIS OF THE GYNECOLOGIC CANCER
| Project/Area Number |
14571598
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Fukuoka University |
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Principal Investigator |
EMOTO Makoto FUKUOKA UNIVERSITY, SCHOOL OF MEDICINE, ASSISTANT PROFESSOR, 医学部, 講師 (80258540)
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| Co-Investigator(Kenkyū-buntansha) |
ONO Mayumi KYUSHU UNIVERSITY, FACULTY OF MEDICINE, ASSOCIATE PROFESSOR, 大学院・医学研究院, 講師 (80128347)
OHSHIMA Kouichi FUKUOKA UNIVERSITY, SCHOOL OF MEDICINE, ASSOCIATE PROFESSOR, 医学部, 助教授 (50203766)
TAMURA Riko 福岡大学, 医学部, 助手 (20330920)
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| Project Period (FY) |
2002 – 2004
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| Keywords | ANGIOGENESIS / GYNECOLOGIC CANCER / UTERINE CANCER / UTERINE SARCOMA / ANGIOGENESIS INHIBITOR / VEGF / ANGIOPOIETIN / TNP-470 |
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| Research Abstract |
1.We studied the molecular and biological characteristics of gynecologic cancers including ovarian, endometrial, and uterine corpus malignancies. A strong expression of VEGF-A mRNA was significantly seen in uterine carcinosarcomas compared to endometrial carcinomas. Moreover, the Ang-2 mRNA expression was significantly seen in most carcinosarcomas, in comparison to that of endometrial carcinomas. In ovarian epithelial cancers, VEGF-C, VEGF-D, and VEGFR-3 were shown to play an important role in the tumor development and lymphatic spreads. In endometrial carcinomas, the presence of VEGF-D, and VEGFR-3 were associated with the tumor invasiveness. VEGF family and the receptors may be promising targets for anti-angiogenic therapy in these gynecologic cancers.
2.We also examined the activity of the anti-angiogenic agents (TNP-470 and/or JNK-1) for gynecologic cancers using our human uterine carcinosarcoma cell lines, FU-MMT-1, FU-MMT-2, in vitro and in vivo. VEGF production was significantly suppressed by TNP-470 in vitro. Both agents showed growth inhibitory and anti-angiogenic effects for these cell lines.
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