2003 Fiscal Year Final Research Report Summary
Direct administration therapy for irreversible peripheral vestibular disorder
| Project/Area Number |
14571621
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SHIMOGORI Hiroaki Yamaguchi University, School of Medicine, Assistant professor, 医学部附属病院, 講師 (70226273)
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| Project Period (FY) |
2002 – 2003
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| Keywords | vestibular disorder / aminoglycoside / AMPA / edaravone / CNQX |
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| Research Abstract |
We evaluated the effects of edaravone, a free radical scavenger, on the vestibular disorder induced by streptomycin (SM) or AMPA
1. Lesions were made in the guinea pig right inner ear by intracochlear administration of 30% SM for 24 h using osmotic pump. Systemic administration of edaravone improved vestibulo-ocular reflex gain in guinea pigs at 3 and 7 days after lesions were made. Local application of edaravone suppressed the frequency of spontaneous nystagmus observed in guinea pigs after lesions were made
2. Lesions were made in the guinea pig right inner ear by infusion of AMPA (10 mM, 50 μl) for 5 min using syringe pump. After AMPA infusion, spontaneous nystagmus was observed, and simultaneous infusion of CNQX, a potent AMPA receptor antagonist, suppressed the frequency of nystagmus in a dose-dependent manner. Local application of edaravone also suppressed the nystagmus, furthermore, early (within 12 h) application of edaravone improved a response for caloric stimulation at 1 w after lesions were made
We concluded that local application of edaravone may be one of the treatment for vestibular disorder caused by aminoglycoside or glutamate excitotoxicity
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