2004 Fiscal Year Final Research Report Summary
The relationship between effect of anti-glaucoma medication and genetic variation.
| Project/Area Number |
14571663
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gifu University |
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Principal Investigator |
KAWASE Kazuhide Gifu University, Graduate School of Medicine, Associate professor, 大学院・医学研究科, 助教授 (40234067)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Tetsuya Gifu University, Graduate School of Medicine, Professor, 大学院・医学研究科, 教授 (50134581)
SUGIYAMA Kazuhisa Kanazawa University, School of Medicine, Professor, 医学部, 教授 (80179168)
HIGASHIDE Tomomi Kanazawa University, School of Medicine, Assistant professor, 医学部, 講師 (20291370)
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| Project Period (FY) |
2002 – 2004
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| Keywords | glaucoma / Gene / anti-glaucoma medication / receptor gene / SNP |
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| Research Abstract |
We investigated relationship between effect of anti-glaucoma medication and genetic variation. First, we screened the relationship of SNP of beta-1 adrenergic receptor and diurnal variation of intraocular pressure in the patient with normal-tension glaucoma. Because, the diurnal curve of intraocular pressure is related from adrenergic effect and beta adrenergic receptor blocker is one of anti-glaucoma medication. But we could not detect any relationship between SNP of beta-1 adrenergic receptor and diurnal variation of intraocular pressure. We are going to start the genomic projects of glaucoma and anti-glaucoma medications.
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