2003 Fiscal Year Final Research Report Summary
THERAPY FOR MACULAR EDEMA AND RETINAL DETACHMENT BY USING WATER CHANNEL PROTEIN AQUAPORIN.
| Project/Area Number |
14571678
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nagasaki University |
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Principal Investigator |
KITAOKA Takashi Nagasaki University, GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, Assistant Professor, 大学院・医歯薬学総合研究科, 教授 (80234235)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Tsukihiko Nagasaki University, GRADUATE SCHOOL OF BIOMEDICAL SCIENCES, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (50346962)
MIYAMURA Noritake Nagasaki University, Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (20343345)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Aquaporin / retina / macula / internal limiting membrane / diabetes mellitus / vitrectomy / analysis / electron microscopy |
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| Research Abstract |
Aquaporin (AQP) is a water channel protein which has been preserved through animals, plants, and microorganelles. In ophthalmological field, the eye and AQP have important relationship,such as that AQP exists in ciliary body, and that AQP 4 and 5 are related to the production and secretion of tear film. It was also reported that AQP 4 exists in the plasma membrane of Mueller cells. We reported that AQP exists in the internal limiting membrane which excised during vitrectomy. We discovered that AQP is more expressed in the internal limiting membrane of diabetic patient than that of non-diabetic patient. This may indicate that AQP is increasing to absorb edema or that AOP increase edema.
On the other hand, it is well known that visual field defect occur after vitrectomy and we reported that hyperbaric oxygenation therapy decreased this visual field defect. This may indicate the expression of AQP is affected by oxygen. After that, we reported that the wall between vitreous pocket and Cloquet's canal may cause several diseases such as vitreo-retinal traction syndrome and retinal edema by using Triamcinolone acetonide. Finally, we used ion microscope to detect the ion and organic which showed the possibility to observe the distribution of AQP.
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