2003 Fiscal Year Final Research Report Summary
Basic and Clinical Investigations of the Multifocal Electroretinogram s-Wave for the Purpose of Clinical Application
| Project/Area Number |
14571684
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Iwate Medical University School of Medicine |
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Principal Investigator |
TAZAWA Yutaka Iwate Medical University School of Medicine, Ophthalmology, Professor, 医学部, 教授 (70048312)
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| Co-Investigator(Kenkyū-buntansha) |
FUJITA Satoshi Iwate Medical University School of Medicine, Ophthalmology, Fellow, 医学部, 助手 (60337152)
KOBAYASHI Takaki Iwate Medical University School of Medicine, Ophthalmology, Fellow, 医学部, 助手 (40326666)
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| Project Period (FY) |
2002 – 2003
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| Keywords | multifocal electroretinotgram / s-wave / retinal ganglion cell / glaucoma / 網膜 / 緑内障 / 視野 |
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| Research Abstract |
We recently found a positive wavelet, designated as "s-wave", on the descending limb of P1 on the first-order kernel of human mfERG when the stimulus frequency was reduced. The purpose of this project is to investigate the characteristics of the s-wave, to confirm its origin, then to aim to clinical application. Results obtained in this project are as follows. (1) We obtained the optimum recording condition for the mfERG s-wave. (2) The s-wave amplitude increased with a decrease of stimulus frequency. (3) The s-wave recorded from regions close to the optic disc was significantly larger in amplitude and shorter in implicit time than that recorded far from the optic disc. (4) The s-wave amplitude decreased in eyes in old age group and eyes with high refractive error. (5) In glaucomatous eyes, the s-wave amplitude was significantly smaller than that recorded from normal eyes. (6) The s-wave amplitudes in glaucomatous eyes were significantly decreased as the visual field loss increased. (7) In glaucoma eyes, the reduction in amplitude of the s-wave was correlated significantly with the retinal nerve fiber layer thickness. (8) In patients with optic neuritis, the s-waves were markedly reduced or lost, and reappeared when the optic neuritis resolved. (9) The s-wave could be recorded from cat eyes too. (10) The cat s-wave disappeared by agents which block the retinal ganglion cells (RGCs) and amacrine cells injected into the vitreous cavity. (11) These findings strongly suggest that the s-wave is originated from the neural activity of RGCs and their axons. (12) Applicability of the cat eye to studies of the s-wave is confirmed. (13) We have reported these results on articles and at meetings.
Recording the s-wave of the mfERG might contribute to observation of the RGCs and their axons in various eye diseases. The s-wave could be an indicator of function of RGCs as one of objective examinations
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