2004 Fiscal Year Final Research Report Summary
The pathogenesis and simulation model of autonomic nerve response in the intraocular blood flow disorders
| Project/Area Number |
14571690
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Nihon University |
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Principal Investigator |
YAMAZAKI Yoshio Nihon University, School of Medicine, Associate Professor, 医学部, 助教授 (30175658)
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| Co-Investigator(Kenkyū-buntansha) |
KASHIMA Yoji Nihon University, School of Medicine, Associate Professor, 医学部, 助教授 (70194719)
INUI Shigeri Nihon University, School of Medicine, Associate Professor, 工学部, 助教授 (40176409)
IWATA Mitsuhiro Nihon University, School of Medicine, Assistant Professor, 医学部, 講師 (50193751)
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| Project Period (FY) |
2002 – 2004
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| Keywords | retrobulbar blood microcirculation / ocular hypertension / blood vessel dilation / autonomic nerve / reduction of intraocular pressure / ocular perfusion pressure |
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| Research Abstract |
[Background/aim] The intraocular blood flow is autoregulated over wide range of ocular perfusion pressure (OPP). The purpose of this study is to investigate whether a reduction of intraocular pressure (IOP) may improve intraocular hemodynamics in human eyes.
[Methods] 26 patients with primary open angle glaucoma (POAG) about to undergo trabeculectomy were included in the study. Patients were evaluated before surgery and at 3,6,9,12 months after trabeculectomy. Blood flow resistance of central retinal artery (CRA) and short posterior ciliary artery (SPCA) in both eyes were assessed with color Doppler imaging. Function of retinal ganglion cells were obtained with visual field examination.
[Results] IOP in the operated eye was significantly decreased after trabeculectomy, and OPP was significantly increased for each postoperative visits. Blood flow resistance of CRA and SPCA were significantly decreased, and retinal light sensitivity was significantly increased in the operated eye. IOP in the unoperated eye, OPP, blood flow resistance of CRA and SPCA, and retinal light sensitivity did not significantly change.
[Conclusion] The results of this study suggest that a reduction of IOP improves ocular blood flow and function of retinal ganglion cell in patients with POAG.
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