The Function of Th-1 and Th-2 cytokine on herpetic stromal keratitis

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14571695
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hyogo College of Medicine
• Principal Investigator: KANNO Sanae Hyogo College of Medicine, Faculty of Medicine, Assistant Professor, 医学部, 講師 (10289069)
• Co-Investigator(Kenkyū-buntansha): OKAMURA Haruki Hyogo College of Medicine, Faculty of Medicine, Professor, 医学部, 教授 (60111043)
• Project Period (FY): 2002 – 2003
• Keywords: herpetic keratitis / Th-1,Th-2 / IFN-γ / IL-18 / mouse / animal

Research Abstract

Experimental herpetic keratitis is effected by Th-1 and Th-2 balance in cornea. In early stage of keratitis, Th-1 cytokine is dominant, in later Th-2 is dominant.
IL-18 is potential IFN-γ producing factor and modulator of inflammation. We are interested in the function on cornea and herpetic keratitis.
B6 mouse(Th-1 dominant mouse) is heavier inflammation on the cornea. Balb/c mouse(Th-2 dominant) is not serious on the cornea but become encephalitis and die. IL-4,IL-10 and IL-12 is measured in cornea on herpetic keratitis both B6 mouse and Balb/c mouse.
All cytokine in serum is same pattern both B6 mouse and Balb/c mouse on early and later stage of herpetic keratitis, so we concluded no significant chane Th-1/Th-2 balance.