Control Mechanism of Intestinal Pacemaker Cell on Upper Gastrointestinal Motor Function

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14571703
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pediatric surgery
• Research Institution: Osaka University
• Principal Investigator: HASAGAWA Toshimichi Osaka University, Graduate School of Medicine, Assistant Professor, 医学系研究科, 助手 (20294085)
• Co-Investigator(Kenkyū-buntansha): HIROTA Seiichi Osaka University, Hospital, Associate Professor, 医学部附属病院, 助教授 (50218856)
• Project Period (FY): 2002 – 2003
• Keywords: Intestinal Pacemaker cell / Microchannel monometry / Upper gastrointestiral motor function / Infantile Hypertrophic pyloric stenosis / Atropine therapy / Coordinatory movement / Congenital esophaged stenosis / Pyloric spsms

Research Abstract

Although intestinal pacemaker cell is said to control the motor function of the intestinal smooth muscle, the exact etiology is unknown. We investigated the intestinal motor function in the rat by using manometry with small-diameter catheter and multiple channels. Although the rhythmic waves were observed in the antrum, pylorus and duodenum in the fasting rats, the changes of the rhythmic waves after feeding or vagal stimulation could not be observed. Therefore, we have observed the upper gastrointestinal motor function in the clinical subjects by using manometry with multiple channels.
In the infants with hypertrophic pyloric stenosis, characteristic aphasic and tonic entractile activity in the gastroduodenal junction is uncoordinated with the antral contractions. Such incoordination may be an important factor in the disturbed transpyloric flow. In the pediatric patients with congenital esophageal stenosis, the presence of gastroesophageal reflux and impaired esophageal motility are common.