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2003 Fiscal Year Final Research Report Summary

Experimental study on therapy for oral cancer by cyclooxygenase-2 inhibitors

Research Project

Project/Area Number 14571904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNara Medical University

Principal Investigator

YAMAMOTO Kazuhiko  Nara Medical University, Oral and Maxillofacial Surgery, Assistant professor, 医学部, 講師 (20243842)

Co-Investigator(Kenkyū-buntansha) KIRITA Tadaaki  Nara Medical University, Oral and Maxillofacial Surgery, Professor, 医学部, 教授 (70201465)
DENDA Ayumi  Nara Medical University, Oncological Pathology, Assistant professor, 医学部, 講師 (90110858)
Project Period (FY) 2002 – 2003
Keywordscyclooxygenase-2 / etodolac / 4-nitroquinoline 1-oxide / tongue cancer / rat / chemoprevention / nitric oxide synthase
Research Abstract

We analyzed the efficacy of selective cyclooxygense(COX)-2 inhibitors, nimesulide and etodolac, in the rat model of tongue carcinogenesis using 4-nitroquinoline 1-oxide(4-NQO) in order to evaluate their chemopreventive efficacy on human oral cancers and reported the suppressive effect of these inhibitors on the development of squamous cell carcinomas(SCCs) and squamous cell daplasias, putative preneoplastis lesions. The present study was conducted to elucidate the roles of COX-2 in rat tongue carcinogenesis. Rats were administered 4-NQO (25-35 ppm) for 12 weeks and then etodolac (150ppm and 300ppm) was given for 16 weeks. The effect of etodolac on the incidence of neoplastic and preneoplastic lesions and the immunohistochemical expression of COX-2 and inducible nitoric oxide synthase (iNOS) in these lesions were analyzed. Etodolac at the dose of 300ppm significantly suppressed the incidence of SCCs from 100% to 50% in parallel with the increase of the incidence of dysplasias. The size of SCCs was also decreased. These results indicate that etodolac suppressed the progression of dysplasias to SCCs and the proliferative potential of SCCs. Immunohistochemical study on the expression of COX-2 and iNOS revealed that etodolac had no effect on the expression of COX-2 or iNOS. From these results, it is considered that the suppressive effect of etodolac on the development of SCCs was not exerted by the inhibition of COX-2 protein expression but by the inhibition of the enzymatic activity of COX-2.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Kazuhiko Yamamoto et al.: "Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas of the tongue in rats initiated with 4-nitroquinoline 1-oxide"Cancer Letter. 199(2). 121-129 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuhiko Yamamoto, Wakashi kitayama, Ayumi Denda, Ayumu Morisaki, Hiroki Kuniyasu, Tadaaki Kirita: "Inhibitory effects of selective cyclooxygenase-2 inhibitors, nimesulide and etodolac, on the development of squamous cell dysplasias and carcinomas in the tongue of rats initiated by 4-nitroquinoline 1-oxide"Cancer Lett. 199(2). 121-129 (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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