2003 Fiscal Year Final Research Report Summary
Development of new periodontal treatment based on the suppression of ostaoclast differentiation factor (ODE) on T cells and osteoblasts
| Project/Area Number |
14571977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
NAGASAWA Toshiyuki Tokyo Medical and Dental University, Department of Hard Tissue Engineering, Research Associate, 大学院・医歯学総合研究科, 助手 (90262203)
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| Co-Investigator(Kenkyū-buntansha) |
NOGUCHI Kazuyuki Tokyo Medical and Dental University, Department of Hard Tissue Engineering, Research Associate, 大学院・医歯学総合研究科, 助手 (90218298)
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| Project Period (FY) |
2002 – 2003
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| Keywords | osteoclast differentiation fact / OPG / RANKL / T cell / periodontitis |
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| Research Abstract |
The purpose of the present study was to investigate the expression of osteoclast differentiation factor (ODE) and osteopmtegerin (OPG) in periodontitis, and develop a novel treatment to suppress the ODF in periodontitis. The results of the study were as follows;
1) Human gingival fibroblasts express OPG, but they don't express ODE suggesting that human gingival fibroblasts suppress osteoclastogenesis.
2) Human periodontal ligament cells expressed ODF in response to inflammatory stimulation, suggesting that inflammation extending to periodontal ligament might augment alveolar bone resorption.
3) Human periodontal ligament cells produce bone morphogenetic protein (BMP) -2 in response to transforming growth factor beta(TGF-b).
These results suggests that adequate amount of human gingival fibroblasts are needed to suppress osteoclastogenesis in periodontitis, arid it is important to evade the inflammation in near the periodontal ligament cells.
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