2003 Fiscal Year Final Research Report Summary

Catalytic Hydroacylatlon using Rhodium Complex

Research Project

Project/Area Number	14572007
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Chemical pharmacy
Research Institution	Kyushu University
Principal Investigator	SUEMUNE Hiroshi Kyushu University, Graduate School of Pharmaceutical Sciences, Professor, 薬学研究院, 教授 (20095897)
Project Period (FY)	2002 – 2003
Keywords	Hydroacylation / rhodium complex / catalytic reaction / double chelation / diene / asymmetric reaction
Research Abstract	Intermolecular hydroacylation between salicylaldehyde and 1,4-penta-or 1,5-hexadienes by Rh-catalyst proceeded under mild reaction conditions to give a mixture of iso-and normal-hydroacylated products. In the hydroacylation reaction, chelation of both salicylaldehyde and diene to the Rh-complex play a crucial role. The ratio of iso-and normal-hydroacylated products could be regulated by the addition of salicylic acid or amines. The effects of various Rh-complexes, solvents, and additives were examined, and the plausible mechanisms of the catalytic cycle were proposed on the basis of the basis of the deuterium-labeling salicylaldehyde experiments.

(4 results)