2004 Fiscal Year Final Research Report Summary
Search for Novel Anti-cancer molecules from Plant Sources as Seeds of Possible Medicinal Agents.
| Project/Area Number |
14572019
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
FURUKAWA Hiroshi Meijo University, Pharmacy, Professor, 薬学部, 教授 (00076712)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Chihiro Meijo University, Pharmacy, Associate Professor, 薬学部, 助教授 (60193497)
ITOIGAWA Masataka Human Wellnes Tokai-gakuenn University, Professor, 人間健康学部, 教授 (90168336)
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| Project Period (FY) |
2002 – 2004
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| Keywords | Guttiferae / Leguminosae / Rutaceae / Euphorbiaceae / alkaloids / biological activity / coumarins / cinnamylphenols |
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| Research Abstract |
Plants contain many kinds of constituents and are a valuable source of new and biologically active molecules. The purpose of this project was the search of novel biologically active molecules from higher plants as a resource of possible anti-cancer agents. The summary of the results is shown below:
1. Isolation and Structure Elucidation of Plants Constituents: The scientific names of plants used and general names of isolated new compounds were shown below :
(1) Guttiferae Plants : Garcinia fusca (eight new xanthones), G. assigu (two new polyprenylated benzophenones), Calophyllum brasiliense (three new coumarins)
(2) Leguminosae Plants : Dalbergia cultrata, D. nigrescense, D. olibari (five new cinnamylphenols and two isoflavonoids), Milletia taiwaniana (five new isoflavonoids)
(3) Rutaceae Plants : Glycosm is arborea (three new carbazoles), Orixa japonica (four new quinolones), Murraya exotica (two new bicoumarins)
(4) Euphorbiaceae Plant : Croton jatrophoides (two new triterpenoids)
2. Biological activity assays for new and known plant constituents were carried out :
(1) Inhibitory effects on EBV-EA activation induced by TPA in Raji cells : benzophenones, cinnamylphenols, coumarins, acridones, carbazoles, phenyppropanoids, phytoquinoids.
(2) Inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis : acrid on es, isoflavonids.
(3) Radical scavenging ability against DPPH : benzophenones.
(4) Inhibitory effect of NO production in murine macrophage-like RAW 264.4 cells : quinolones, quinolines.
(5) Inhibition of leukemic cell growth : 4-substituted coumarins.
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[Journal Article] Inhibition of Leukemic Cell Growth by a Novel Anti-Cancer Drug (GUT 70) from Calophyllum brasiliense that Acts by Induction of Apoptosis2005
Author(s)
Shinaya Kimura, Chihiro Ito, Naoto Jyoko, Hidekazu Segawea, Junya Kuroda, Masayuki Okada, Souichi Adachi, Tatsutoshi Nakahata, Takeshi Yuasa, Valdir Cechinel Filho, Hiroshi Furukawa, Taira Maekawa
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Journal Title
Int.J.Cancer 113
Pages: 158-165
Description
「研究成果報告書概要(欧文)」より
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