2003 Fiscal Year Final Research Report Summary
Identification of the susceptive genes for hypercholesterolemia and hypoalphalipoproteinemia by Genome-wide linkage analysis
| Project/Area Number |
14572140
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | University of Shizuoka (2003)
University of Tsukuba (2002) |
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Principal Investigator |
KOBAYASHI Kimiko Univ. of Shizuoka, School of Food and Nutritional Sciences, Associate Professor, 食品栄養科学部, 助教授 (90215319)
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| Co-Investigator(Kenkyū-buntansha) |
YANAGI Hisako Univ.of Tsukuba, institute of community Medicine, Associate Professor, 社会医学系, 助教授 (10241811)
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| Project Period (FY) |
2002 – 2003
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| Keywords | Quantitative-trait-locus / genome-wide linkage search / hypercholesterolemia / hypoalphalipoproteinemia |
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| Research Abstract |
We conducted a genome-wide linkage search for susceptibility gene influencing interindividual variation in serum lipid levels in a Japanese population. We have analyzed genotypic data of 352 microsatellite markers in 43 Japanese families (172 members) of probands with hypercholesterolemia. Quantitative-trait-locus (QTL) analysis for serum lipid levels was carried out by a Haseman-Elston method. We have observed significant LOD scores for the linkage of serum total cholesterol level on D3S1580, D11S935, and D15S120. In addition, we have observed significant in another 32 Japanese families (138 members). Only the linkage between serum total cholesterol level and D3S1580 have been ascertained. These data suggest that the chromosomal region around D3S1580 may be a susceptibility region influencing variation in total cholesterol level. Further investigation will be necessary to identify and test plausible candidate genes for hypercholesterolemia and hypoalphalipoproteinemia in this region.
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