2003 Fiscal Year Final Research Report Summary
Telomere as a possible marker for aging of cardiovascular system
| Project/Area Number |
14572183
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
OZONO Ryoji Hiroshima University, Medical and Dental Hospital, Assistant Professor, 医学部・歯学部附属病院, 講師 (00304436)
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| Co-Investigator(Kenkyū-buntansha) |
HIYAMA Eiso Hiroshima University, Medical and Dental Hospital, Associate Professor, 医学部・歯学部附属病院, 助教授 (00218744)
KAMBE Masayuki Hiroshima University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (70034139)
OSHIMA Tetsuya Hiroshima University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授 (40233100)
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| Project Period (FY) |
2002 – 2003
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| Keywords | science of longevity / aging / oxidative stress / telomere / atherosclerosis / hypertension / risk factors / ischemic heart disease |
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| Research Abstract |
A chronological aging does not always parallel a biological aging, but any useful biomarker for the latter is not available. Telomeres undergo progressive attrition with each replicative cycle of the cell, eventually triggering a conversion into an aged phenotype of the cell. We hypothesized that the mean telomere length in tissues could be a useful marker for the biological aging of the tissues. We found that the mean telomere length of leukocytes decreases with age, but the extent of which is greater in patients with cardiovascular disease. When cardiovascular damage was estimated by scoring the presence of cardiovascular risk factors and history of cardiovascular events, the score was negatively correlated with telomere length of leukocytes, independently of the age of subjects. These observations support a notion that the leukocyte telomere length is a possible biomarker for cardiovascular aging
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