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2003 Fiscal Year Final Research Report Summary

The role of energy metabolic abnormality in cardiac hypertrophy.

Research Project

Project/Area Number 14580015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionChiba University

Principal Investigator

KASUYA Yoshitoshi  Chiba University, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (70221877)

Co-Investigator(Kenkyū-buntansha) MIYAUCHI Takashi  Tsukuba Univ., Clinical Medical Sciences, Professor, 臨床医学系, 教授 (60222329)
NISHIYAMA Mariko  Chiba University, Graduate School of Medicine, Assistant, 大学院・医学研究院, 助手 (00092081)
KIMURA Sadao  Chiba University, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (40134225)
MATUDA Mituo  Tsukuba Univ., Health, Physical and Sports Sciences, Professor, 体育科学系, 教授 (20110702)
Project Period (FY) 2002 – 2003
Keywordscardiac hypertrophy / PPAR-α / Fenofibrate / Endothelin(ET)-1 / rat cardiomyocytes / aortic banding model / MAP kinases / JNK
Research Abstract

We investigated possible roles of PPAR-α activation in ET-1-induced hypertrophy of cultured rat cardiomyocytes and in an in vivo model of cardiac hypertrophy (abdominal aortic banding : AB). Fenofibrate markedly inhibited the ET-1-induced increase in cell size, protein synthesis, expression level of c-Jun and phosphorylation level of c-Jun and JNK. PPAR-α overexpression inhibited ET-1-induced increase in protein synthesis. Fenofibrate significantly inhibited the ET-1-induced ET-1 mRNA expression, which was confirmed by luciferase assay. EMSA revealed that fenofibrate decreased AP-1 binding activity induced by ET-1 or PMA. Fenofibrate-treatment inhibited LV hypertrophy and phenotypic changes in cardiac gene expression in AB rats.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] Yoko Irukayama-Tomobe: "Endothelin-1-induced caidiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH_2-terminal kinase pathway."Circulation. 109. 904-910 (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoko Irukayama-Tomobe: "Activation of peroxisome proliferator-activated receptor-α (PPAR-α) decreases endothelin-1-induced p38 Mitogen-activated protein kinase (MAPK) activation in cardiomyocytes."J.Cardiovasc.Pharmacol.. (in press). (2004)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoko Irukayama-Tomobe, et al.: "Endothelin-1-induced cardiac hypertrophy is inhibited by activation of peroxisome proliferator-activated receptor-α partly via blockade of c-Jun NH_2-terminal kinase pathway."Circulation. 109. 904-910 (2004)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoko Irukayama-Tomobe, et al.: "Activation of peroxisome proliferator activated receptor-α (PPAR-α) decreases endothelin-1-induced p38 Mitogen-activated protein kinase (MAPK) activation in cardiomyocytes."J.Cardiovasc.Pharmacol. (in press). (2004)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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