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2003 Fiscal Year Final Research Report Summary

THE RESPONSES OF STRESS PROTEINS TO MORPHOLOGICAL AND FUNCTIONAL CHANGES OF RAT SKELETAL MUSCLES

Research Project

Project/Area Number 14580043
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 体育学
Research InstitutionKumamoto University

Principal Investigator

OISHI Yasuharu ph.d.  KUMAMOTO UNIVERSITY, FACULTY OF EDUCATION, ASSOCIATE PROFESSOR, 教育学部, 助教授 (10203704)

Project Period (FY) 2002 – 2003
Keywordsheat shock proteins / myosin heavy chain / HSP72 / muscle hypertrophy / muscle atrophy / heat stress / clenbuterol / soleus / plantaris / rat
Research Abstract

1)Heat shock protein (HSP) 72 was expressed specifically in slow type I fiber that was composed mainly of slow type I myosin heavy chain (MHC) isoform in embryonic rat skeletal muscles.
2)The expression level of HSP72 was gradually increased in rat slow soleus muscle, whereas the HSP72 level was constantly lower level in the fast plantaris muscle than the soleus, during the developmenta stage (〜8-week).
3)The induction of some HSPs (Hsp60, HSP72, or HSC73) after heat stress (incresing the muscle temperature) was specific for each muscle or muscle regions.
4)The expression level of HSP72 was decresed in clenbuterol-induced hypertrophied rat soleus muscle. The slow type I fiber/myosin heavy chain was also decreased in the soleus. These results suggested that the expression of HSP72 was close more to the changes of muscle fiber phenotype than fiber size.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Oishi et al.: "Muscle type-specific response of HSP60, HSP72, and HSC73 during recovery after elevation of muscle temperature"J.Appl.Physiol.. 92. 1097-1103 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oishi et al.: "Clenbuterol induces expression of multiple myosin heavy chain isoforms in rat soleus fibres."Acta Physiol.Scand.. 176. 311-318 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogata, Oishi et al.: "Endogenous expression and developmental changes of HSP72 in rat skeletal muscles"J.Appl.Physiol.. 95. 1279-1286 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oishi et al.: "Differential responses of HSPs to heat stress in slow and fast regions of rat gastrocnemius muscle."Muscle & Nerve. 28. 587-594 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oishi et al.: "Enhancement of HSP72 in reloading rat soleus muscle after prolonged hindlimb unloading."Jpn.J.Physiol.. 53. 281-286 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuoka et al.: "Chemoreflex drive and the dynamics of ventilation and gas exchange during exercise at hypoxia."Am.J.Respir.Crit.Care Med.. 168. 1115-1122 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasuharu Oishi, Kouhachi Taniguchi, Hisahiro Matsumoto, Akihiko Ishihara, Yoshinobu Ohira, Roland R.Roy: "Muscle type-specific response of HSP60, HSP72 and HSC73 during recovery after the elevation of muscle temperature."J.Appl.Physiol.. 92. 1097-1103 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuharu Oishi, Kohjiro Imoto, Tomonori Ogata, Kouhachi Taniguchi, Hisahiro Matsumoto, Roland R.Roy: "Clenbuterol induces expression of multiple myosin heavy chain isoforms in rat soleus fibers."Acta Physiol Scand. 176. 311-318 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tomonori Ogata, Yasuharu Oishi, Roland R Roy, Hajime Ohmori: "Endogeneous expression and developmental changes of HSP72 in rat skeletal muscles."J Appl Physiol. 95. 1279-1286 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuharu Oishi, Kouhachi Taniguchi, Hisahiro Matsumoto, Akihiko Ishihara, Yoshinobu Ohira, Roland R.Roy: "Differential responses of HSPs to heat stress in slow and fast regions of rat gastrocnemius muscle."Muscle & Nerve. 28. 587-594 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuharu Oishi, Kouhachi Taniguchi, Hisahiro Matsumoto, Fuminori Kawano, Akihiko Ishihara, Yoshinobu Ohira: "Enhancement of HSP72 in reloading rat soleus muscle after prolonged hindlimb unloading."Jpn J Physiol. 53. 281-286 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshiyuki Fukuoka, Masako Endo, Yasuharu Oishi, Haruo Ikegami: "Chemoreflex drive and the dynamics of ventilation and gas exchange during exercise at hypoxia."Am J Respir Crit Care Med. 168. 1115-1122 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasuharu Oishi, Kohjiro Imoto, Tomonori Ogata, Kouhachi Taniguchi, Hisahiro Matsumoto, Yoshiyuki Fukuoka, Roland R Roy: "Calcineurin and heat-shock proteins modulation in clenbuterol-induced hypertrophied rat skeletal muscles."Pflugers Archiv Eur J Physiol. 448. 114-122 (2004)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2005-04-19  

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