Approach from nutritional therapy to immune-allergic disorders

2003 Fiscal Year Final Research Report Summary

• Project/Area Number: 14580148
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: 食生活
• Research Institution: JAPAN WOMEN'S UNIVERSITY
• Principal Investigator: SATO Kazuto Japan Women's Univ., Faculty of Home Economics, Professor, 家政学部, 教授 (40187175)
• Project Period (FY): 2002 – 2003
• Keywords: immunity / allergy / nutrition / autoimmune diseases / obesity

Research Abstract

A.Allergy and nutrition
1.Obesity and immunity/allergy
1) Effect of obesity on allergic asthma
Effect of obesity on pathophysiology of antigen-specific allergic asthma was investigated by using diet induced-obese mice. Functional changes of T lymphocytes rather than immediate-type hypersensitivity was more involved in the asthma with obesity.
2) Effect of leptin in vivo on immunity with obesity
Sensitivity of lymphocyte to leptin was altered in obesity, which might relate with immuno-regulatory changes in the condition.
2.Oral tolerance and dietary fatty acids
IgE production in oral tolerance induction was altered by n-6/n-3 ratio of PUFA in dietary fatty acids, which may influence to pathophysiology of allergy.
B.Autoimmune diseases and nutrition
1.Oral tolerance induction and estrogen in arthritis model mice
Oral tolerance induction was affected by estrogen administration in arthritis, which implies the importance of hormonal condition in nutritional therapy.
2.Immunity in mother-child relationship was investigated in arthritis model.

Research Products

• [Publications] Natsuko Mito: "Effect of obesity and insulin on the immunity in non-insulin dependent diabetes mellitus"Eur J Clin Nutr. 56. 347-351 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Natsuko Mito: "Effect of diet-induced obesity on OVA specific immune response in murine asthma model"Metabolism. 51. 1241-1246 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Kalina U: "Enhanced IL-18 production in butyrate-treated intestinal epithelium by stimulation of the proximal IL-18 promoter region"Eur J Immunol. 32. 2635-2643 (2002)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Tomoko Hosoda: "Estrogen altered oral tolerance induction in typeII collagen-induced murine arthritis"Int Arch Allerg Immunol. 133. 19-28 (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Natsuko Mito: "Analysis of the effect of leptin on immune function in vivo using diet-induced obese mice"J Endocrinol. 180. 167-173 (2004)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Natsuko Mito, Toni Hiyoshi, Tomoko Hosoda, Chiaki Kitada, Kazuto Sato: "Effect of obesity and insulin on immunity in non-insulin-dependent diabetes mellitus"European Journal of Clinical Nutrition. 56. 347-351 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Natsuko Mito, Chiaki Kitada, Tomoko Hosoda, Kazuto Sato: "Effect of diet-induced obesity of OVA specific immune response in murine asthma model"Metabolism. 51. 1241-1246 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Uwe Kalina, Noriko Koyama, Tomoko Hosoda, Heike Nuemberger, Kazuto Sato, Dieter Hoelzer, Frank Herweck, Tobias Manigold, Manfred V.Singer, Siegbert Rossol, Ulrich Bocker: "Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region"European Journal of Immunology. 32. 2635-2643 (2002)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Tomoko Hosoda, Natsuko Mito, Haruka Yoshino, Kazuto Sato: "Estrogen altered oral tolerance induction in typeII collagen-induced murine arthritis"Int Arch Allerg Immunol. 133. 19-28 (2004)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Natsuko Mito, Haruka Yoshino, Tomoko Hosoda, Kazuto Sato: "Analysis of the effect of leptin on immune function in vivo using diet-induced obese mice"J Endocrinol. 180. 167-173 (2004)
  • Description: 「研究成果報告書概要(欧文)」より