2003 Fiscal Year Final Research Report Summary
Synaptic regulation of ghrelin neurons on feeding-regulating neurons and its signal transduction
| Project/Area Number |
14580734
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Showa University |
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Principal Investigator |
GUAN Jian-lian Showa Univ., Sch.Med., Assistant, 医学部, 助手 (20276538)
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| Co-Investigator(Kenkyū-buntansha) |
SHIODA Seiji Showa Univ., Sch.Med., Professor, 医学部, 教授 (80102375)
FUNAHASHI Hisayuki Showa Univ., Sch.Med., Assistant Professor, 医学部, 講師 (20317514)
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| Project Period (FY) |
2002 – 2003
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| Keywords | ghrelin / neuropeptide Y / orexin / feeding regulation / synapse / signal transduction |
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| Research Abstract |
Ghrelin is a first identified peptide in stomach as an endogenous ligand for growth hormone-releasing factor receptor. Soon after it was discovered in the hypothalamus, it is shown to have a strong effect on appetite regulation. We studied the functional significance of ghrelin on feeding regulation by use of morphological and physiological methods. We first found that some of the orexin-positive axon terminals made synapses on ghrelin-positive neurons in the lateral hypothalamus. Orexin increased the cytosolic Ca concentration in ghrelin-containing neurons isolated from the hypothalamic arcuate nucleus. Ghrelin-positive neurons were sometimes found postsynaptically to glirelin-positie axon terminals. These findings suggest that orexin and ghrelin serve as transmitters and/or modulators that increase cytosolic Ca in ghrelin-containing neurons. It is suggested that orexin regulates the functions of ghrelin-containing neurons which participate in the control of feeding. Recently, we found that neuropeptide Y-and ghrelin-positive neurons could influence each other by synaptic transmission through synapses, and suggests that they will join a common effort to regulate the food-intake behavior through the complex synaptic relationships. Further detailed studies are needed to clarify appetite regulation in the hypothalamus and other brain regions.
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[Publications] Lu S, Guan IL, Wang QP, Uehara K, Yamada S, Goto N, Date Y, Nakazato M, Kojima M, Kangawa K, Shioda S.: "Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus."Neurosci Lett. 321. 157-160 (2002)
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[Publications] Toshinai K, Date Y, Murakami N, Shimada M, Guan JL, Wang QP, Funahashi H, Sakural T, Shioda S, Matsukura S, Kangawa K, Nakazato M.: "Ghrelin-induced food intake is mediated via orexin pathway."Endocrinology. 144. 1506-1512 (2003)
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