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2015 Fiscal Year Annual Research Report

ウシ小型ピロプラズマ病における貧血病態と発症機序の解明

Research Project

Project/Area Number 14F04087
Research InstitutionObihiro University of Agriculture and Veterinary Medicine

Principal Investigator

横山 直明  帯広畜産大学, 原虫病研究センター, 教授 (80301802)

Co-Investigator(Kenkyū-buntansha) SIVAKUMAR THILLAIAMPALAM  帯広畜産大学, 原虫病研究センター, 外国人特別研究員
Project Period (FY) 2014-04-25 – 2016-03-31
Keywords小型ピロプラズマ病 / 牛 / 貧血 / 発症 / 原虫 / タイレリア
Outline of Annual Research Achievements

最終年度では、以下の研究成果を得た。
1)小型ピロプラズマ感染による放牧牛の貧血病態は宿主免疫の異常バランスに起因する大球性高色素性貧血であることを解明した。
2)スリランカ、エジプト、ベトナム、モンゴル、及びタイにおける牛やマダニのピロプラズマ感染の実態を国際疫学調査によって明らかにした。
3)ピロプラズマ病の治療薬の候補を同定した。

Research Progress Status

27年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

27年度が最終年度であるため、記入しない。

  • Research Products

    (16 results)

All 2016 2015 Other

All Int'l Joint Research (5 results) Journal Article (8 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 8 results,  Acknowledgement Compliant: 3 results) Presentation (2 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Int'l Joint Research] 獣医学研究所(スリランカ)

    • Country Name
      SRI LANKA
    • Counterpart Institution
      獣医学研究所
  • [Int'l Joint Research] モンゴル農業大学(モンゴル)

    • Country Name
      MONGOLIA
    • Counterpart Institution
      モンゴル農業大学
  • [Int'l Joint Research] フエ大学/フエ農林大学(ベトナム)

    • Country Name
      VIET NAM
    • Counterpart Institution
      フエ大学/フエ農林大学
  • [Int'l Joint Research] サダト大学(エジプト)

    • Country Name
      EGYPT
    • Counterpart Institution
      サダト大学
  • [Int'l Joint Research] 国立動物科学研究所(タイ)

    • Country Name
      THAILAND
    • Counterpart Institution
      国立動物科学研究所
  • [Journal Article] Type-specific PCR assays for Babesia bovis msa-1 genotypes in Asia: Revisiting the genetic diversity in Sri Lanka, Mongolia, and Vietnam.2016

    • Author(s)
      Liyanagunawardena N, Sivakumar T, Kothalawala H, Silva SS, Battsetseg B, Lan DT, Inoue N, Igarashi I, Yokoyama N.
    • Journal Title

      Infect Genet Evol.

      Volume: 37 Pages: 64-69

    • DOI

      10.1016/j.meegid.2015.10.029.

    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The PCR detection and phylogenetic characterization of Babesia microti in questing ticks in Mongolia.2015

    • Author(s)
      Tuvshintulga B, Sivakumar T, Battsetseg B, Narantsatsaral SO, Enkhtaivan B, Battur B, Hayashida K, Okubo K, Ishizaki T, Inoue N, Igarashi I, Yokoyama N.
    • Journal Title

      Parasitol Int.

      Volume: 64 Pages: 527-532

    • DOI

      10.1016/j.parint.2015.07.007.

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genetic variations in merozoite surface antigen genes of Babesia bovis detected in Vietnamese cattle and water buffaloes.2015

    • Author(s)
      Yokoyama N, Sivakumar T, Tuvshintulga B, Hayashida K, Igarashi I, Inoue N, Long PT, Lan DT.
    • Journal Title

      Infect Genet Evol.

      Volume: 30 Pages: 288-295

    • DOI

      10.1016/j.meegid.2014.12.035.

    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genetic diversity in Trypanosoma theileri from Sri Lankan cattle and water buffaloes.2015

    • Author(s)
      Yokoyama N, Sivakumar T, Fukushi S, Tattiyapong M, Tuvshintulga B, Kothalawala H, Silva SS, Igarashi I, Inoue N.
    • Journal Title

      Vet Parasitol.

      Volume: 207 Pages: 335-41

    • DOI

      10.1016/j.vetpar.2014.12.006.

    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] An epidemiological survey of bovine Babesia and Theileria parasites in cattle, buffaloes, and sheep in Egypt.2015

    • Author(s)
      Elsify A, Sivakumar T, Nayel M, Salama A, Elkhtam A, Rizk M, Mosaab O, Sultan K, Elsayed S, Igarashi I, Yokoyama N.
    • Journal Title

      Parasitol Int.

      Volume: 64 Pages: 79-85

    • DOI

      10.1016/j.parint.2014.10.002

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of inhibitory effect of methylene blue against Babesia and Theileria parasites.2015

    • Author(s)
      Tuvshintulga B, Sivakumar T, Salama AA, Yokoyama N, Igarashi I.
    • Journal Title

      J. Protozool. Res.

      Volume: 25 Pages: 18-28

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] First detection of Babesia venatorum (EU1) in Ixodes persulcatus ticks in Mongolia.2015

    • Author(s)
      Tuvshintulga B, Battsetseg B, Battur B, Myagmarsuren P, Narantsatsral S, Sivakumar T, Takemae H, Igarashi I, Inoue N, Yokoyama N.
    • Journal Title

      J. Protozool. Res.

      Volume: 25 Pages: 29-37

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Analysis of the genetic diversity of Babesia bovis msa-1 in Thailand using type-specific polymerase chain reaction.2015

    • Author(s)
      Tattiyapong M, Sivakumar T, Takemae H, Simking P, Jittapalapong S, Igarashi I, Yokoyama N.
    • Journal Title

      J. Protozool. Res.

      Volume: 25 Pages: 38-43

    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Type-specific PCR assays for Babesia bovis msa-1 genotypes in Asia: Revisiting the genetic diversity in Sri Lanka, Mongolia, and Vietnam.2015

    • Author(s)
      Sivakumar T, Inoue N, Igarashi I, Yokoyama N.
    • Organizer
      第56回日本熱帯医学会大会
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2015-12-04 – 2015-12-06
  • [Presentation] Molecular epidemiology of Babesia and Theileria, and Trypanosoma in cattle and water buffaloes in Sri Lanka.2015

    • Author(s)
      Sivakumar T, Kothalawala H, Silva SSP, Yokoyama N.
    • Organizer
      57th Annual Convention of the Sri Lanka Veterinary Association
    • Place of Presentation
      Oak-Ray and Earl's Regency (Kandy, Sri Lanka)
    • Year and Date
      2015-07-19 – 2015-07-20
    • Int'l Joint Research
  • [Remarks] 帯広畜産大学・原虫病研究センター ホームページ

    • URL

      http://www.obihiro.ac.jp/~protozoa/index.html

URL: 

Published: 2016-12-27  

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