近縁種で独立に生じた全ゲノム重複が解明する全ゲノム重複のメカニズムとインパクト

2014 Fiscal Year Annual Research Report

• Project/Area Number: 14F04382
• Research Institution: The University of Tokyo
• Principal Investigator: 岩崎 渉 東京大学, 理学系研究科, 准教授 (50545019)
• Co-Investigator(Kenkyū-buntansha): SRISWASDI Sira 東京大学, 理学系研究科, 外国人特別研究員
• Project Period (FY): 2014-04-25 – 2017-03-31
• Keywords: バイオインフォマティクス / ゲノム / 進化

Outline of Annual Research Achievements

In this project, we aim to understand how neofunctionalization and subfunctionalization occur and whether they are driven by particular genetic elements or functions of nearby genes after whole-genome duplication (WGD). So far, we identified and characterized evidences of WGD from newly sequenced genomes of seventeen fungi species. Notably, using synteny detection, we discovered two WGD events; the first evidence of two independent WGD events in close lineages. Analysis of duplicated gene retention patterns confirmed that these WGD events occurred independently. Our preliminary gene ontology enrichment analyses agreed well with previously published study of WGD in the Saccharomyces. Furthermore, our initial analysis of gene order rearrangements suggested that WGD plays an important role in optimizing the organization of genes on the genome.

Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

The study proceeded well.

Strategy for Future Research Activity

We will continue analyzing the genome data as planned.