2016 Fiscal Year Annual Research Report
体内環境下における最先端人工関節材料のビーリングスの分光学的・力学的評価
| Project/Area Number |
14F04783
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
PEZZOTTI G. 京都工芸繊維大学, 材料化学系, 教授 (70262962)
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| Co-Investigator(Kenkyū-buntansha) |
MRIN ELIA 京都工芸繊維大学, 材料化学系, 外国人特別研究員
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| Project Period (FY) |
2014-04-25 – 2017-03-31
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| Keywords | tribology / biomaterials / ceramics / prosthetic implants / osteointegration / lubrication / metal staining / silicon nitride |
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| Outline of Annual Research Achievements |
This research project provided a further insight on the durability of various ceramic biomaterials applied in orthopaedic prosthetic implants both in-vitro and in-vivo. Simulated wear testing and retrieved materials analysis clearly showed that most commonly applied ceramic biomaterials (monolithic alumina, zirconia and zirconia toughened alumina) degrade in-vivo at a rhythm which is significantly higher when compared to conventional laboratory simulations. It was also shown that metal staining caused by dislocation of the implant, leads to an even faster degradation. The presence of lubrication limits the severity of the tribological contact reducing the friction coefficient but might promote the transformation of tetragonal zirconia into monoclinic, reducing the mechanical properties of the implant. The concept of bioinert biomaterials has then been questioned: even oxides, which are extremely stable from a chemical point of view, have a clear and unexpected interaction with the human body environment. Taking into account these results, silicon nitride has been introduced as an alternative biomaterial. Studies conducted in-vitro clearly showed that Si3N4 positively interact with the human body environment and can thus be successfully used for different applications, from promotion of bone growth and osteointegration (e.g.: in spinal implants or bone fillers) to wear resistance (e.g.: in femoral heads for hip implants). The additional anti-bacterial effect granted by Si3N4 has never been observed before for other conventional ceramic material used in orthopaedics.
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| Research Progress Status |
28年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
28年度が最終年度であるため、記入しない。
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[Journal Article] Vibrational monitor of early demineralization in tooth enamel after in vitro exposure to phosphoridic liquid2017
Author(s)
G. Pezzotti, T. Adachi, I. Gasparutti, G. Vincini, W. Zhu, M. Boffelli, A. Rondinella, E. Marin, H. Ichioka, T. Yamamoto, Y. Marunaka, N. Kanamura
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Journal Title
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
Volume: 1732017
Pages: 19-33
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] In Situ Spectroscopic Screening of Osteosarcoma Living Cells on Stoichiometry-Modulated Silicon Nitride Bioceramic Surfaces2016
Author(s)
G. Pezzotti, B.J. McEntire, R. Bock, W. Zhu, F. Boschetto, A. Rondinella, E. Marin, Y. Marunaka, T. Adachi, T. Yamamoto, N. Kanamura, B.S. Bal
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Journal Title
ACS Biomaterials Science & Engineering
Volume: 2(7)
Pages: 1121-1134
DOI
Peer Reviewed / Int'l Joint Research
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[Journal Article] Effect of etching on the composition and structure of anodic spark deposition films on titanium2016
Author(s)
E. Marin, M.V. Diamanti, M. Boffelli, M. Sendoh, M.P. Pedeferri, A. Mazinani, M. Moscatelli, B. Del Curto, W. Zhu, G. Pezzotti, R. Chiesa
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Journal Title
Materials & Design
Volume: 108
Pages: 77-85
DOI
Peer Reviewed / Int'l Joint Research
