Formation of the integrated insulin secretion system and its failure

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 15002002
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Kobe University
• Principal Investigator: SEINO Susumu Kobe University, Graduate School of Medicine, Professor (80236067)
• Co-Investigator(Kenkyū-buntansha): YOKOI Norihide Kobe University, Graduate School of Medicine, Associate Professor (70311610) ; SHIBASAKI Tadao Kobe University, Graduate School of Medicine, Assistant Professor (00323436) ; IWANAGA Toshihiko Hokkaido University, Graduate School of Medicine, Professor (10160128)
• Project Period (FY): 2003 – 2007
• Keywords: Diabetes / Cell signaling / Development&Differentiation / Bioimaging / Insulin secretion / Gene

Research Abstract

1) How is insulin secretory function acquired during β-cell differentiation? (1) We have demonstrated directly by cell lineage tracing that pancreatic acinar cells can transdifferentiate into insulin-secreting cells in vitro. Destruction and remodeling of cadherin-mediated cell-cell adhesion was found to be important for the transdifferentiation, and activation of PI3-kinase was required for these processes. (2) We have shown that pancreatic β-cells of Kir6.2G132S transgenic mice were spontaneously regenerated, and that intraislet DBA-labeled cells may represent progenitors for the β-cells. (3) We have identified a novel transcriptional factor, Mgx-1 (Isx), which is expressed specifically in gut. Isx inactivation is required for the gut-derived cell to express Pdx1 and Insulin2.
2) How are the signaling components in insulin secretion spatially and temporally integrated in β-cells? (1) Both 1st and 2nd phases of glucose-induced fusion event involved mostly granules that are newly recrui ted and immediately fused to the plasma membrane without docking (restless newcomer). (2) Activation of cAMP signaling clearly potentiated both phases of glucose-induced fusion events. All granules responsible for this potentiation were restless newcomer. We have found that Epac2/Rap1 signaling is essential in the potentiation of insulin granule exocytosis by cAMP, primarily in the first phase of cAMP-potentiated exocytosis, by increasing the number of restless newcomer. (3) We have proposed that Epac2-containing cAMP compartment is distinct from PKA-containing compartment.
3) How do B-cells interact functionally with other organs such as the brain and gastrointestine? (1) Although K_<ATP> channel-deficient mice lack glucose-induced insulin secretion, we found that gastrointestinal hormone incretin (such as GLP-1 and GIP) is released by food ingestion and endows Kir6.2^<-/-> β-cells with glucose responsiveness. (2) By studying the mice deficient in an exocytosis-related molecule Noc2, we found that Noc2 elicits an inhibitory effect on G_<i/o> mediated suppression of insulin secretion.
4) Pathophysiology due to defects in the system (1) We have generated mice deficient in transcription factor Otx3 (Dmbxl), which we previously identified in insulinoma cell lines. By cross-breeding with agouti yellow (Ay) mice, a hereditary mouse model of obesity and diabetes, we found that Dmbx1 is essential for developing obesity and diabetes of Ay mice. (2) Type 1 diabetes was reconstituted on a non-KDP genetic background with the two major susceptibility genes, MHC-RT1u and Cblb mutation, in the rat. By association study of variants involved in pancreatic β-cell function in Japanese type 2 diabetes, a significant association of a variant in SUR1(ABCC8) was found.

Research Products

• [Journal Article] Identification and functional analysis of CBLB mutations in type l diabetes (2008)
  • Author(s): Yokoi N, et al.
  • Journal Title: Biochem Biophys Res Commun 368 Pages: 37-42
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Isx participates in the maintenance of vitamin A metabolism by regulation of β-carotene 15, 15'-monooxygenase (Bcmo1) expression (2008)
  • Author(s): Seino Y, et al.
  • Journal Title: J Biol Chem 283 Pages: 4905-4911
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] K_<ATP> channel-deficient pancreatic β-cells are streptozotocin resistant because of lower GLUT2 activity (2008)
  • Author(s): Xu J, et al.
  • Journal Title: Am J Physiol 294 Pages: E326-335
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Involvement of Exoc31, a protein structurally related to the exocyst subunit Sec6, in insulin secretion (2008)
  • Author(s): Saito T, et al.
  • Journal Title: Biomed Res (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of cadherin-mediated cell-cell adhesion in pancreatic exocrine-to-endocrine transdifferentiation (2008)
  • Author(s): Minami K, et al.
  • Journal Title: J Biol Chem 283 Pages: 13753-13761
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification and functional analysis of CBLB mutations in type 1 diabetes. (2008)
  • Author(s): Yokoi N, Fujiwara Y, Wang HY, Kitao M, Hayashi C, Someya T, Kanamori M, Oiso Y, Tajima N, Yamada Y, Seino Y, Ikegami H, Seino S
  • Journal Title: Biochem Biophys Res Commun 368 Pages: 37-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Isx participates in the maintenance of vitamin A metabolism by regulation of β-carotene 15, 15'-monooxygenase (Bcmo1) expression. (2008)
  • Author(s): Seino Y, Miki T, Kiyonari H, Abe T, Fujimoto W, Kimura K, Takeuchi A, Takahashi Y, Oiso Y, Iwanaga T, Seino S
  • Journal Title: J Biol Chem 283 Pages: 4905-4911
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] K_<ATP> channel-deficient pancreatic β-cells are streptozotocin resistant because of lower GLUT2 activity. (2008)
  • Author(s): Xu J, Zhang L, Chou A, Allaby T, Belanger G, Radziuk J, Jasmin BJ, Miki T, Seino S, Renaud JM
  • Journal Title: Am J Physiol 294 Pages: E326-335
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of cadherin-mediated cell-cell adhesion in pancreatic exocrine-to-endocrine transdifferentiation. (2008)
  • Author(s): Minami K, Okano H, Okumachi A, Seino S
  • Journal Title: Biol Chem 283 Pages: 13753-13761
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PKA-independent mechanism of cAMP in insulin secretion. (2008)
  • Author(s): Seino S, Miki T, Shibasaki T
  • Journal Title: Pancreatic Beta Cell in Health and Disease.(Seino S and Bell GI (eds.). Springer) Pages: 133-146
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dmbxl is essential in agouti-related protein action (2007)
  • Author(s): Fujimoto W, et al.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 15514-15519
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP (2007)
  • Author(s): Shibasaki T, et al.
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 19333-19338
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes (2007)
  • Author(s): Okuno M, et al.
  • Journal Title: Am J Physiol 292 Pages: E158-165
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genetic reconstitution of autoimmune type l diabetes with two major susceptibility genes in the rat (2007)
  • Author(s): Yokoi N, et al.
  • Journal Title: Diabetes 56 Pages: 506-512
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Induction by NeuroD of the components required for regulated exocytosis (2007)
  • Author(s): Ishizuka N, et al.
  • Journal Title: Biochem Biophys Res Commun 354 Pages: 271-277
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse (2007)
  • Author(s): Teramae H, et al.
  • Journal Title: Histochem Cell Biol 127 Pages: 1-11
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice (2007)
  • Author(s): Miyake, et al.
  • Journal Title: Eur J Neurosci 25 Pages: 2349-2363
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] K_<ATP> channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart (2007)
  • Author(s): Gumina RJ, et al.
  • Journal Title: Am J Physiol 292 Pages: H1706-1713
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] K_<ATP> channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation (2007)
  • Author(s): Olson TM, et al.
  • Journal Title: Nat Clin Pract Cardiovasc Med 4 Pages: 110-116
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] K_<ATP> channels confer survival advantage in cocaine overdose (2007)
  • Author(s): Reyes S, et al.
  • Journal Title: Mol Psychiatry 12 Pages: 1060-1061
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 膵β細胞研究と糖尿病 (2007)
  • Author(s): 清野 進(依頼執筆)
  • Journal Title: 日本眼科学会紀要 57 Pages: 171-175
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 膵腺房細胞からインスリン分泌細胞への分化転換. (2007)
  • Author(s): 南幸太郎, 他(依頼執筆)
  • Journal Title: 医学のあゆみ 220 Pages: 1145-1148
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dmbx1 is essential in agouti-related protein action. (2007)
  • Author(s): Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M, Iwanaga T, Seino S
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 15514-15519
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. (2007)
  • Author(s): Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, Seino S
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 19333-19338
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes. (2007)
  • Author(s): Okuno M, Minami K, Okumachi A, Miyawaki K, Yokoi N, Toyokuni S, Seino S
  • Journal Title: Am J Physiol 292 Pages: E158-165
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Geneticreconstitution of autoimmune type 1 diabetes with two major susceptibility genes in the rat. (2007)
  • Author(s): Yokoi N, Hayashi C, Fujiwara Y, Wang HY, Seino S
  • Journal Title: Diabetes 56 Pages: 506-512
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Induction by NeuroD of the components required for regulated exocytosis. (2007)
  • Author(s): Ishizuka N, Minami K, Okumachi A, Okuno M, Seino S
  • Journal Title: Biochem Biophys Res Commun 354 Pages: 271-277
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cellular expression of Noc2, a Rab effector protein, in endocrine and exocrine tissues in the mouse. (2007)
  • Author(s): Teramae H, Fujimoto W, Seino S, Iwanaga T
  • Journal Title: Histochem Cell Biol 127 Pages: 1-11
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Disruption of Kir6.2-containing ATP-sensitive potassium channels impairs maintenance of hypoxic gasping in mice. (2007)
  • Author(s): Miyake A, Yamada K, Kosaka T, Miki T, Seino S, Inagaki N
  • Journal Title: Eur J Neurosci 25 Pages: 2349-2363
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] K_<ATP> channel knockout worsens myocardial calcium stress load in vivo and impairs recovery in stunned heart. (2007)
  • Author(s): Gumina RJ, O'Cochlain DF, Kurtz CE, Bast P, Pucar D, Mishra P, Miki T, Seino S, Macura S, Terzic A
  • Journal Title: Am J Physiol 292 Pages: H1706-1713
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] K_<ATP> channel mutation confers risk for vein of Marshall adrenergic atrial fibrillation. (2007)
  • Author(s): Olson TM, Alekseev AE, Moreau C, Liu XK, Zingman LV, Miki T, Seino S, Asirvatham SJ, Jahangir A, Terzic A
  • Journal Title: Nat Clin Pract Cardiovasc Med 4 Pages: 110-116
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] K_<ATP> channels confer survival advantage in cocaine overdose. (2007)
  • Author(s): Reyes S, Kane GC, Miki T, Seino S, Terzic A
  • Journal Title: Mol Psychiatry 12 Pages: 1060-1061
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sui β-saibou kenkyu to tounyoubyou (2007)
  • Author(s): Seino S
  • Journal Title: Nippon gankagakkai kiyou 57 Pages: 171-175
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Suisenbou saibou kara insulin bunpitsu saibou eno bunka tenkan. (2007)
  • Author(s): Minami K, Seino S
  • Journal Title: Igaku no ayumi 220 Pages: 1145-1148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Shizen hassyou ichigata tounyoubyou doubutsu no genin idenshi. (2007)
  • Author(s): Yokoi N, Seino S
  • Journal Title: Tounyoubyougaku kiso to rinsyou. (Nishimura Co., Ltd.) Pages: 291-293
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Suisenbou saibou no bunkan tenkan niyoru insulin bunpitsu saibou no sakusyutsu. (2007)
  • Author(s): Minami K, Okuno M, Miyawaki K, Seino S
  • Journal Title: Tounyoubyougaku2007, (Shindan to Chiryou Co., LTD.) Pages: 84-97
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Suisenbou saibou no bunkan tenkan niyoru Sui β-saibou saisei no kanousei. (2007)
  • Author(s): Minami K, Seino S
  • Journal Title: Bunshi tounyougaku no shinpo kiso kara rinsyou made-2007. (KANEHARA Co., LTD.) Pages: 22-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion (2006)
  • Author(s): Kawaguchi M, et al.
  • Journal Title: J Biol Chem 281 Pages: 13015-13020
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Spontaneous recovery from hyperglycemia by regeneration of pancreatic β-cells in Kir6.2G132S transgenic mice (2006)
  • Author(s): Oyama K, et al.
  • Journal Title: Diabetes 55 Pages: 1930-1938
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification and characterization of a novel member of the ATP-sensitive K^+ channelsubunit family, Kir6.3, in zebrafish. (2006)
  • Author(s): Zhang C, et al.
  • Journal Title: Physiol Genomics 24 Pages: 290-297
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Association studies of variants in the genes involved in pancreatic beta-cell function intype 2 diabetes in Japanese subjects (2006)
  • Author(s): Yokoi N, et al.
  • Journal Title: Diabetes 55 Pages: 2379-2386
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protection conferred by myocardial ATP-sensitive K^+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant (2006)
  • Author(s): Yamada S, et al.
  • Journal Title: J Physiol 577 Pages: 1053-1065
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K^+ channels (2006)
  • Author(s): Sun HS, et al.
  • Journal Title: J Neurophysiol 95 Pages: 2590-2601
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cerebral glucose transporters expression and spatial learning in the K-ATPKir6^<-/->knockout mice. (2006)
  • Author(s): Choeiri C, et al.
  • Journal Title: Behav Brain Res 172 Pages: 233-239
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Behavioral phenotyping of mice lacking the K_<ATP> channel subunit Kir6.2 (2006)
  • Author(s): Deacon RM, et al.
  • Journal Title: Physiol Behav 87 Pages: 723-733
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] KCNJ11 gene knockout of the Kir6.2 K_<ATP> channel causes maladaptive remodeling and heart failure in hypertension . (2006)
  • Author(s): Kane GC, et al.
  • Journal Title: Hum Mol Genet 15 Pages: 2285-2297
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gene knockout of the KCNJ8-encoded Kir6.1 K_<ATP> channel imparts fatal susceptibility to endotoxemia (2006)
  • Author(s): Kane GC, et al.
  • Journal Title: FASEB J 20 Pages: 2271-2280
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] シグナル受容機構の解明が導く創薬・治療への躍進 : シグナル受容と疾患 膵β細胞からのインスリン分泌制御シグナルとその破綻 (2006)
  • Author(s): 三木隆司, 他(依頼執筆)
  • Journal Title: 実験医学 24 Pages: 758-763
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] cAMPシグナルによるエキソサイトーシスの調節機構. (2006)
  • Author(s): 柴崎忠雄, 他(依頼執筆)
  • Journal Title: 生体の科学 57 Pages: 91-95
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 膵腺房細胞の分化転換によるインスリン分泌細胞の誘導 (2006)
  • Author(s): 南幸太郎, 他(依頼執筆)
  • Journal Title: 最新医学 61 Pages: 1496-1501
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Essential role of ubiquitin-proteasome system in normal regulation of insulin secretion. (2006)
  • Author(s): Kawaguchi M, Minami K, Nagashima K, Seino S
  • Journal Title: J Biol Chem 281 Pages: 13015-13020
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Spontaneous recovery from hyperglycemia by regeneration of pancreatic β-cells in Kir6.2G132S transgenic mice. (2006)
  • Author(s): Oyama K, Minami K, Ishizaki K, Fuse M, Miki T, Seino S
  • Journal Title: Diabetes 55 Pages: 1930-1938
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of a novel member of the ATP-sensitive K^+ channel subunit family, Kir6.3, in zebrafish. (2006)
  • Author(s): Zhang C, Miki T, Shibasaki T, Yokokura M, Saraya A, Seino S
  • Journal Title: Physiol Genomics 24 Pages: 290-297
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association studies of variants in the genes involved in pancreatic β-cell function in type 2 diabetes in Japanese subjects. (2006)
  • Author(s): Yokoi N, Kanamori M, Horikawa Y, Takeda J, Sanke T, Furuta H, Nanjo K, Mori H, Kasuga M, Hara K, Kadowaki T, Tanizawa Y, Oka Y, Iwami Y, Ohgawara H, Yamada Y, Seino Y, Yano H, Cox NJ, Seino S
  • Journal Title: Diabetes 55 Pages: 2379-2386
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protection conferred by myocardial ATP-sensitive K^+ channels in pressure overload-induced congestive heart failure revealed in KCNJ11 Kir6.2-null mutant. (2006)
  • Author(s): Yamada S, Kane GC, Behfar A, Liu XK, Dyer RB, Faustino RS, Miki T, Seino S, Terzic A
  • Journal Title: J Physiol 577 Pages: 1053-1065
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K^+ channels. (2006)
  • Author(s): Sun HS, Feng ZP, Miki T, Seino S, French RJ
  • Journal Title: J Neurophysiol 95 Pages: 2590-2601
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cerebral glucose transporters expression and spatial learning in the K-ATP Kir6.2^<-/-> knockout mice. (2006)
  • Author(s): Choeiri C, Staines WA, Miki T, Seino S, Renaud JM, Teutenberg K, Messier C
  • Journal Title: Behav Brain Res 172 Pages: 233-239
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Behavioral phenotyping of mice lacking the K_<ATP> channel subunit Kir6.2. (2006)
  • Author(s): Deacon RM, Brook RC, Meyer D, Haeckel O, Ashcroft FM, Miki T, Seino S, Liss B
  • Journal Title: Physiol Behav 87 Pages: 723-733
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] KCNJ11 gene knockout of the Kir6.2 K_<ATP> channel causes maladaptive remodeling and heart failure in hypertension. (2006)
  • Author(s): Kane GC, Behfar A, Dyer RB, O'Cochlain DF, Liu XK, Hodgson DM, Reyes S, Miki T, Seino S, Terzic A
  • Journal Title: Hum Mol Genet 15 Pages: 2285-2297
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gene knockout of the KCNJ8-encoded Kir6.1 K_<ATP> channel imparts fatal susceptibility to endotoxemia. (2006)
  • Author(s): Kane GC, Lam CF, O'Cochlain F, Hodgson DM, Reyes S, Liu XK, Miki T, Seino S, Katusic ZS, Terzic A
  • Journal Title: FASEB J 20 Pages: 2271-2280
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Shigunaru jyuyou kikou no kaimei ga michibiku souyaku chiryou eno tyouyaku : shigunaru jyuyou to shikkan Sui β-saibou karano insulin bunpitsu seigyo shigunaru to sono hatan. (2006)
  • Author(s): Miki T, Seino S
  • Journal Title: Jikken igaku 24 Pages: 758-763
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] cAMP shigunaru niyoru exocytosis no tyousetsu kikou (2006)
  • Author(s): Shibasaki T, Seino S
  • Journal Title: Seitai no kagaku 57 Pages: 91-95
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Suisenbou saibou no bunka tenkan niyoru insulin bunpitsu saibou no yuudou. (2006)
  • Author(s): Minami K, Seino S
  • Journal Title: Saishin igaku 61 Pages: 1496-1501
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] cAMP compartment to insulin bunpitsu. (2006)
  • Author(s): Shibasaki T, Seino S
  • Journal Title: Bunshi tounyougaku no shinpo kiso kara rinsyou made-2006. (KANEHARA Co., LTD.) Pages: 2-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells (2005)
  • Author(s): Minami K, et al.
  • Journal Title: Proc Natl Acad Sci USA 102 Pages: 15116-15121
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Distinct effects of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility (2005)
  • Author(s): Miki T, et al.
  • Journal Title: Diabetes 54 Pages: 1056-1063
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Direct inhibition of the interaction between a-interaction domain and β-interaction domain of voltage-dependent Ca^<2+> channels by Gem (2005)
  • Author(s): Sasaki T, et al.
  • Journal Title: J Biol Chem 280 Pages: 9308-9312
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Possible role of PEPTl in gastrointestinal hormone secretion (2005)
  • Author(s): Matsumura K, et al.
  • Journal Title: Biochem Biophys Res Commun 336 Pages: 1028-1032
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Functional analysis of transcriptional repressor Otx3/Dmbxl. (2005)
  • Author(s): Kimura K, et al.
  • Journal Title: FEBS Lett 579 Pages: 2926-2932
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons (2005)
  • Author(s): Liss B, et al.
  • Journal Title: Nat Neurosci 8 Pages: 1742-1751
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] PDX-1 protein is internalized by lipid raft-dependent macropinocytosis (2005)
  • Author(s): Noguchi H, et al.
  • Journal Title: Cell Transplant 14 Pages: 637-645
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Glucose transporter plasticity during memory processing (2005)
  • Author(s): Choeiri C, et al.
  • Journal Title: Neuroscience 130 Pages: 591-600
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Treadmill running causes significant fiber damage in skeletal muscle of K_<ATP> channel-deficient mice (2005)
  • Author(s): Thabet M, et al.
  • Journal Title: Physiol Genomics 22 Pages: 204-212
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Role of ATP-sensitive K^+ channels in electrophysiological alterations during myocardialischemia: a study using Kir6.2-null mice (2005)
  • Author(s): Saito T, et al.
  • Journal Title: Am J Physiol 288 Pages: H352-357
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Physical and functional interaction of noc2/rab3 in exocytosis (2005)
  • Author(s): Shibasaki T, Seino S
  • Journal Title: Methods Enzymol 403 Pages: 408-419
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels (2005)
  • Author(s): Kubo Y, et al.
  • Journal Title: Pharmacol Rev 57 Pages: 509-526
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis (2005)
  • Author(s): Seino S, Shibasaki T)
  • Journal Title: Physiol Rev 85 Pages: 1303-1342
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 膵β細胞におけるcAMPコンパートメント (2005)
  • Author(s): 柴崎忠雄, 他(依頼執筆)
  • Journal Title: 最新医学 60 Pages: 2649-2653
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lineage tracing and characterization of insulin-secreting cells generated from adult pancreatic acinar cells. (2005)
  • Author(s): Minami K, Okuno M, Miyawaki K, Okumachi A, Ishizaki K, Oyama K, Kawaguchi M, Ishizuka N, Iwanaga T, Seino S
  • Journal Title: Proc Natl Acad Sci USA 102 Pages: 15116-15121
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Distinct effects of glucosedependent insulinotropic polypeptide and glucagon-like peptide-1 on insulin secretion and gut motility. (2005)
  • Author(s): Miki T, Minami K, Shinozaki H, Matsumura K, Saraya A, Ikeda H, Yamada Y, Holst JJ, Seino S
  • Journal Title: Diabetes 54 Pages: 1056-1063
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Direct inhibition of : the interaction between α-interaction domain and β-interaction domain of voltage-dependent Ca^<2+> channels by Gem. (2005)
  • Author(s): Sasaki T, Shibasaki T, Beguin P, Nagashima K, Miyazaki M, Seino S
  • Journal Title: J Biol Chem 280 Pages: 9308-9312
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Possible role of PEPT1 in gastrointestinal hormone secretion. (2005)
  • Author(s): Matsumura K, Miki T, Jhomori T, Gonoi T, Seino S
  • Journal Title: Biochem Biophys Res Commun 336 Pages: 1028-1032
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Functional analysis of transcriptional repressor Otx3/Dmbx1. (2005)
  • Author(s): Kimura K, Miki T, Shibasaki T, Zhang Y, Ogawa M, Saisho H, Okuno M, Iwanaga T, Seino S
  • Journal Title: FEBS Lett 579 Pages: 2926-2932
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. (2005)
  • Author(s): Liss B, Haeckel O, Wildmann J, Miki T, Seino S, Roeper J
  • Journal Title: Nat Neurosci 8 Pages: 1742-1751
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PDX-1 protein is internalized by lipid raft-dependent macropinocytosis. (2005)
  • Author(s): Noguchi H, Matsumoto S, Okitsu T, Iwanaga Y, Yonekawa Y, Nagata H, Matsushita M, Wei FY, Matsui H, Minami K, Seino S, Masui Y, Futaki S, Tanaka K
  • Journal Title: Cell Transplant 14 Pages: 637-645
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glucose transporter plasticity during memory processing. (2005)
  • Author(s): Choeiri C, Staines W, Miki T, Seino S, Messier C
  • Journal Title: Neuroscience 130 Pages: 591-600
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Treadmill running causes significant fiber damage in skeletal muscle of K_<ATP> channel-deficient mice. (2005)
  • Author(s): Thabet M, Miki T, Seino S, Renaud JM
  • Journal Title: Physiol Genomics 22 Pages: 204-212
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of ATP-sensitive K^+ channels in electrophysiological alterations during myocardial ischemia : a study using Kir6.2-null mice. (2005)
  • Author(s): Saito T, Sato T, Miki T, Seino S, Nakaya H
  • Journal Title: Am J Physiol 288 Pages: H352-357
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Roles of K_<ATP> channels as metabolic sensors in acute metabolic changes. (2005)
  • Author(s): Miki T, Seino S
  • Journal Title: J Mol Cell Cardiol 38 Pages: 917-925
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Physical and functional interaction of noc2/rab3 in exocytosis. (2005)
  • Author(s): Shibasaki T, Seino S
  • Journal Title: Methods Enzymol 403 Pages: 408-419
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. (2005)
  • Author(s): Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA
  • Journal Title: Pharmacol Rev 57 Pages: 509-526
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] PKA-dependent and PKA-independent pathways for cAMP-regulated exocytosis. (2005)
  • Author(s): Seino S, Shibasaki T
  • Journal Title: Physiol Rev 85 Pages: 1303-1342
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sui β-saibou ni okeru cAMP compartment. (2005)
  • Author(s): Shibasaki T, Seino S
  • Journal Title: Saishin igaku 60 Pages: 2649-2653
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Kir6.1, Kir6.2 NC-IUPHAR subcommittee on potassium channels : Kir Group. (2005)
  • Author(s): Seino S
  • Journal Title: The IUPHAR Compendium of Voltage-gated Ion Channels 2005. (Catterall WA, Chandy KG, and Gutman GA (eds.). IUPHAR Media)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Syoukakan no seijyou soshikizou. (2005)
  • Author(s): Iwanaga T
  • Journal Title: Syoukaki shikkan shinryou jissen guide. (BUNKODO Co., LTD.) Pages: 872-882
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tyoukan saibou kinou jikkenhou-"Kougaku kenbikyou niyoru kansatsu" oyobi denshi kenbikyou niyoru kansatsuhou. (2005)
  • Author(s): Iwanaga T
  • Journal Title: Seibutsu kagaku jikkenhou50 Tyoukan saibou kinou jikkenhou. (Japan Scientific Societies Press) Pages: 7-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells (2004)
  • Author(s): Matsumoto M, et al
  • Journal Title: Proc Natl Acad Sci USA 101 Pages: 8313-8318
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Effects of fluoroquinolones on insulin secretion and beta-cell ATP-sensitive K^+ channels (2004)
  • Author(s): Saraya A, et al.
  • Journal Title: Eur J Pharmacol 497 Pages: 111-117
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Interaction of ATP sensor, cAMP sensor, Ca^<2+> sensor, and voltage-dependent Ca^<2+>channel in insulin granule exocytosis (2004)
  • Author(s): Shibasaki T, et al.
  • Journal Title: J Biol Chem 279 Pages: 7956-7961
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Integration of ATP, cAMP, and Ca^<2+> signals in insulin granule exocytosis (2004)
  • Author(s): Shibasaki T, et al.
  • Journal Title: Diabetes 53 Pages: S59-62
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Construction of a multi一functional cDNA library specific for mouse pancreatic islets and its application to microarray (2004)
  • Author(s): Nishimura M, et al.
  • Journal Title: DNA Res 11 Pages: 315-323
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Prediction of the coding sequences of mouse homologues of KlAA gene : IV. The completenucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminalsequences of cDNA clones randomly sampled from size-fractionated libraries (2004)
  • Author(s): Okazaki N, et al.
  • Journal Title: DNA Res 11 Pages: 205-218
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification and characterization of Noc2 as a potential Rab3B effector protein inepithelial cells (2004)
  • Author(s): Manabe S, et al.
  • Journal Title: Biochem Biophys Res Commun 316 Pages: 218-225
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Diet-induced glucose intolerance in mice with decreased β-cell ATP-sensitive K^+ channels (2004)
  • Author(s): Remedi, et al.
  • Journal Title: Diabetes 53 Pages: 3159-3167
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K^+ channel, predisposes to catecholamine-induced ventricular dysrhythmia (2004)
  • Author(s): Liu XK, et al.
  • Journal Title: Diabetes 53 Pages: S165-168
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] ATP-sensitive K^+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits (2004)
  • Author(s): Kane GC, et al.
  • Journal Title: Diabetes 53 Pages: S169-175
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Polymorphic variation in the CBLB gene in human type l diabetes. (2004)
  • Author(s): Kosoy R, et al.
  • Journal Title: Genes Immun 5 Pages: 232-235
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gene targeting approach to clarification of ion channel function : studies of Kir6. x null mice (2004)
  • Author(s): Seino S, Miki T
  • Journal Title: J Physiol 554 Pages: 295-300
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Roles of ATP-sensitive K^+ channels as metabolic sensors : studies of Kir6. x null mice (2004)
  • Author(s): Minami K, et al.
  • Journal Title: Diabetes 53 Pages: S176-180
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Roles of K_<ATP> channels as metabolic sensors in acute metabolic changes (2004)
  • Author(s): Miki T, Seino S
  • Journal Title: J Mol Cell Cardiol 38 Pages: 917-925
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells. (2004)
  • Author(s): Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S
  • Journal Title: Proc Natl Acad Sci USA 101 Pages: 8313-8318
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of fluoroquinolones on insulin secretion and β-cell ATP-sensitive K^+ channels. (2004)
  • Author(s): Saraya A, Yokokura M, Gonoi T, Seino S
  • Journal Title: Eur J Pharmacol 497 Pages: 111-117
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Interaction of ATP sensor, cAMP sensor, Ca^<2+> sensor, and voltage-dependent Ca^<2+> channel in insulin granule exocytosis. (2004)
  • Author(s): Shibasaki T, Sunaga Y, Fujimoto K, Kashima Y, Seino S
  • Journal Title: J Biol Chem 279 Pages: 7956-7961
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Integration of ATP, cAMP, and Ca^<2+> signals in insulin granule exocytosis. (2004)
  • Author(s): Shibasaki T, Sunaga Y, Seino S
  • Journal Title: Diabetes 53 Pages: S59-62
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. (2004)
  • Author(s): Nishimura M, Yokoi N, Miki T, Horikawa Y, Yoshioka H, Takeda J, Ohara O, Seino S
  • Journal Title: DNA Res 11 Pages: 315-323
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prediction of the coding sequences of mouse homologues of KIAA gene : IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. (2004)
  • Author(s): Okazaki N, R FK, Ohara R, Inamoto S, Koseki H, Hiraoka S, Saga Y, Seino S, Nishimura M, Kaisho T, Hoshino K, Kitamura H, Nagase T, Ohara O, Koga H
  • Journal Title: DNA Res 11 Pages: 205-218
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification and characterization of Noc2 as a potential Rab3B effector protein in epithelial cells. (2004)
  • Author(s): Manabe S, Nishimura N, Yamamoto Y, Kitamura H, Morimoto S, Imai M, Nagahiro S, Seino S, Sasaki T
  • Journal Title: Biochem Biophys Res Commun 316 Pages: 218-225
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diet-induced glucose intolerance in mice with decreased β-cell ATP-sensitive K^+ channels. (2004)
  • Author(s): Remedi MS, Koster JC, Markova K, Seino S, Miki T, Patton BL, McDaniel ML, Nichols CG
  • Journal Title: Diabetes 53 Pages: 3159-3167
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Genetic disruption of Kir6.2, the pore-forming subunit of ATP-sensitive K^+ channel, predisposes to catecholamine-induced ventricular dysrhythmia. (2004)
  • Author(s): Liu XK, Yamada S, Kane GC, Alekseev AE, Hodgson DM, O'Cochlain F, Jahangir A, Miki T, Seino S, Terzic A
  • Journal Title: Diabetes 53 Pages: S165-168
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ATP-sensitive K^+ channel knockout compromises the metabolic benefit of exercise training, resulting in cardiac deficits. (2004)
  • Author(s): Kane GC, Behfar A, Yamada S, Perez-Terzic C, O'Cochlain F, Reyes S, Dzeja PP, Miki T, Seino S, Terzic A
  • Journal Title: Diabetes 53 Pages: S169-175
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Polymorphic variation in the CBLB gene in human type 1 diabetes. (2004)
  • Author(s): Kosoy R, Yokoi N, Seino S, Concannon P
  • Journal Title: Genes Immun 5 Pages: 232-235
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gene targeting approach to clarification of ion channel function : studies of Kir6.x null mice. (2004)
  • Author(s): Seino S, Miki T
  • Journal Title: J Physiol 554 Pages: 295-300
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Roles of ATP-sensitive K^+ channels as metabolic sensors : studies of Kir6.x null mice. (2004)
  • Author(s): Minami K, Miki T, Kadowaki T, Seino S
  • Journal Title: Diabetes 53 Pages: S176-180
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] ATP-sensitive K^+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling (2003)
  • Author(s): Minami K, et al.
  • Journal Title: Am J Physiol 285 Pages: E1289-1296
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Establishment and characterization of the Komeda . diabetes-prone rat as a segregating inbred strain (2003)
  • Author(s): Yokoi N, et al.
  • Journal Title: Exp Anim 52 Pages: 295-301
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rat neurological disease creeping is caused by a mutation in the reelin gene (2003)
  • Author(s): Yokoi N, et al.
  • Journal Title: Brain Res Mol Brain Res 112 Pages: 1-7
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice (2003)
  • Author(s): Suzuki M, et al.
  • Journal Title: Circulation 107 Pages: 682-685
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] KATP channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle (2003)
  • Author(s): Gong B, et al.
  • Journal Title: Am J Physiol 285 Pages: C1464-1474
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics (2003)
  • Author(s): Gumina RJ, et al.
  • Journal Title: Am J Physiol 284 Pages: H2106-2113
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Compendium of voltage-gated ion channels : potassium channels (2003)
  • Author(s): Gutman GA, et al.
  • Journal Title: Pharmacol Rev 55 Pages: 583-586
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 1型糖尿病モデルKDPラットの疾患感受性遺伝子のクローニング (2003)
  • Author(s): 横井伯英, 他(依頼執筆)
  • Journal Title: 医学のあゆみ 207 Pages: 613-617
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 全身性エリトマトーデスとシェーングレン症候群を合併した1型糖尿病の1例 (2003)
  • Author(s): 田中正巳, 他(依頼執筆)
  • Journal Title: 糖尿病 46 Pages: 11-14
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 特集:臨床応用の動向と将来への展望. 膵臓を対象とした再生医療 (2003)
  • Author(s): 南幸太郎, 他(依頼執筆)
  • Journal Title: 日本臨床 61 Pages: 504-508
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 膵β細胞の再生医学 (2003)
  • Author(s): 南幸太郎, 他(依頼執筆)
  • Journal Title: 今日の移植 16 Pages: 125-132
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 特集:糖尿病研究の新展開 インスリン分泌の調節機構 (2003)
  • Author(s): 南幸太郎, 他(依頼執筆)
  • Journal Title: 生化学 75 Pages: 1312-1323
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] ATP-sensitive K^+ channel-mediated glucose uptake is independent of IRS-1/phosphatidylinositol 3-kinase signaling. (2003)
  • Author(s): Minami K, Morita M, Saraya A, Yano H, Terauchi Y, Miki T, Kuriyama T, Kadowaki T, Seino S
  • Journal Title: Am J Physiol 285 Pages: E1289-1296
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Establishment and characterization of the Komeda diabetes-prone rat as a segregating inbred strain (2003)
  • Author(s): Yokoi N, Namae M, Fuse M, Wang HY, Hirata T, Seino S, Komeda K
  • Journal Title: Exp Anim 52 Pages: 295-301
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rat neurological disease creeping is caused by a mutation in the reelin gene. (2003)
  • Author(s): Yokoi N, Namae M, Wang HY, Kojima K, Fuse M, Yasuda K, Serikawa T, Seino S, Komeda K
  • Journal Title: Brain Res Mol Brain Res 112 Pages: 1-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cardioprotective effect of diazoxide is mediated by activation of sarcolemmal but not mitochondrial ATP-sensitive potassium channels in mice. (2003)
  • Author(s): Suzuki M, Saito T, Sato T, Tamagawa M, Miki T, Seino S, Nakaya H
  • Journal Title: Circulation 107 Pages: 682-685
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] K_<ATP> channels depress force by reducing action potential amplitude in mouse EDL and soleus muscle. (2003)
  • Author(s): Gong B, Legault D, Miki T, Seino S, Renaud JM
  • Journal Title: Am J Physiol 285 Pages: C1464-1474
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Knockout of Kir6.2 negates ischemic preconditioning-induced protection of myocardial energetics (2003)
  • Author(s): Gumina RJ, Pucar D, Bast P, Hodgson DM, Kurtz CE, Dzeja PP, Miki T, Seino S, Terzic A
  • Journal Title: Am J Physiol 284 Pages: H2106-2113
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels : potassium channels. (2003)
  • Author(s): Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS
  • Journal Title: Pharmacol Rev 55 Pages: 583-586
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Ichigata tounyoubyou model KDP rat no shikkan kanjyusei idenshi no cloning (2003)
  • Author(s): Yokoi N, Seino S
  • Journal Title: Igaku no ayumi 207 Pages: 613-617
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Systemic lupus erythematosus to Sjogren syndrome wo gappei shita ichigata tounyoubyou no ichirei. (2003)
  • Author(s): Tanaka M, Miyazaki Y, Yokoi N, Seino S
  • Journal Title: Tounyoubyou 46 Pages: 11-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tokusyu : Rinsyou ouyou no doukou to syourai eno tenbou suizou wo taisyou tosita saisei iryou. (2003)
  • Author(s): Minami K, Okuno M, Miyawaki K, Seino S
  • Journal Title: Nippon Rinsyou 61 Pages: 504-508
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sui β-saibou no saisei igaku. (2003)
  • Author(s): Minami K, Okuno M, Seino S
  • Journal Title: Konnichi no isyoku 16 Pages: 125-132
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Tokusyu : Tounyoubyou kenkyu no shintenkai insulin bunpitsu no tyousetsu kikou. (2003)
  • Author(s): Minami K, Shibasaki T, Miki T, Seino S
  • Journal Title: Seikagaku 75 Pages: 1312-1323
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Sui β-saibou niokeru glucose outousei to saibounai calcium. (2003)
  • Author(s): Minami K, Yokokura M, Seino S
  • Journal Title: Bunshi tounyougaku no shinpo kiso kara rinsyou made-2003. (KANEHARA Co., LTD.) Pages: 17-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Involvement of Exoc31, a protein structurally related to the exocyst subunit Sec6, in insulin secretion.
  • Author(s): Saito T, Shibasaki T, Seino S
  • Journal Title: Biomed Res (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] cAMPによるインスリン分泌開口分泌の制御 (2008)
  • Author(s): 柴崎忠雄
  • Organizer: 第42回糖尿病学の進歩
  • Place of Presentation: 高松
  • Year and Date: 2008-02-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] cAMP niyoru insulin bunpitsu no seigyo. (2008)
  • Author(s): Shibasaki T, Seino S
  • Organizer: Advances in Diabetology 42nd Annual Post Graduate Course
  • Place of Presentation: Takamatsu
  • Year and Date: 2008-02-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Glycobiologyにおける形態学の貢献-内在性レクチンの発現解析を中心に (2007)
  • Author(s): 岩永敏彦
  • Organizer: 日本解剖学会第53回東北・北海道連合支部学術集会
  • Place of Presentation: 札幌
  • Year and Date: 20070929-20070930
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Glycobiology niokeru keitaigaku no Kouken - Naizaisei lectin no hatsugen kaiseki wo tyuushin ni. (2007)
  • Author(s): Iwanaga T
  • Organizer: The 53rd Annual Meeting of the Japanese Association of Anatomists, Tohoku and Hokkaido Branch
  • Place of Presentation: Sapporo
  • Year and Date: 20070929-20070930
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of insulin granule dynamics. (2007)
  • Author(s): Seino S
  • Organizer: The 33rd Autumn Congress of Korean Diabetes Association
  • Place of Presentation: Busan, Korea
  • Year and Date: 2007-11-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of insulin granule dynamics. (2007)
  • Author(s): Seino S
  • Organizer: The 33rd Autumn Congress of Korean Diabetes Association.
  • Place of Presentation: Busan, Korea
  • Year and Date: 2007-11-09
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of insulin granule dynamics. (2007)
  • Author(s): Seino S
  • Organizer: The 14th Japan-Korea Symposium on Diabetes Mellitus -Diabetes and Metabolic Syndrome in Asia
  • Place of Presentation: 京都
  • Year and Date: 2007-10-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of insulin granule dynamics. (2007)
  • Author(s): Seino S
  • Organizer: 14th Japan-Korea Symposium on Diabetes Mellitus -Diabetes and Metabolic Syndrome in Asia-.
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2007-10-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of insulin granule exocytosis by cAMP. (2007)
  • Author(s): Seino S
  • Organizer: The European Association for the Study of Diabetes (EASD) Islet Study Group Symposium 2007
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2007-09-22
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of insulin granule exocytosis by cAMP. (2007)
  • Author(s): Seino S
  • Organizer: The European Association for the Study of Diabetes (EASD) Islet Study Group Symposium 2007.
  • Place of Presentation: Brussels, Belgium
  • Year and Date: 2007-09-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regulation of Insulin Granule Exocytosis by cAMP (2007)
  • Author(s): Shibasaki T, et al.
  • Organizer: 第50回日本糖尿病学会年次学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2007-05-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regulation of insulin granule exocytosis by cAMP. (2007)
  • Author(s): Shibasaki T, Takahashi H, Seino S
  • Organizer: The 50th Annual Meeting of the Japan Diabetes Society
  • Place of Presentation: Sendai
  • Year and Date: 2007-05-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Role of cAMP signaling in insulin granule exocytosis (2006)
  • Author(s): Seino S
  • Organizer: The 6th Congress of the Federation of Asian and Oceanian Physiological Societies
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2006-10-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Role of cAMP signaling in insulin granule exocytosis. (2006)
  • Author(s): Seino S
  • Organizer: The 6th Congress of the Federation of Asian and Oceanian Physiological Societies.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2006-10-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regeneration of pancreatic β-cells : in vitro and in vivo models (2006)
  • Author(s): Seino S
  • Organizer: The 10th Chinese Diabetes Society Scientific Congress
  • Place of Presentation: Guangzhou, China
  • Year and Date: 2006-10-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regeneration of pancreatic β-cells : in vitro and in vivo models. (2006)
  • Author(s): Seino S
  • Organizer: The 10th Chinese Diabetes Society Scientific Congress.
  • Place of Presentation: Guangzhou, China.
  • Year and Date: 2006-10-09
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膵β細胞障害の分子機構 (2006)
  • Author(s): 清野 進
  • Organizer: 第41回糖尿病学の進歩
  • Place of Presentation: 札幌
  • Year and Date: 2006-09-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 膵β細胞の研究の進歩と展望 (2006)
  • Author(s): 清野 進
  • Organizer: 第49回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2006-05-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Sui β-saibou no kenkyuu no shinpo to tenbou. (2006)
  • Author(s): Seino S
  • Organizer: The 47th Annual Meeting of the Japan Diabetes Society
  • Place of Presentation: Tokyo
  • Year and Date: 2006-05-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膵β細胞の機能と再生 (2006)
  • Author(s): 清野 進
  • Organizer: 第79回日本内分泌学会学術総会
  • Place of Presentation: 神戸
  • Year and Date: 2006-05-20
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Sui β-saibou no kinou to saisei. (2006)
  • Author(s): Seino S
  • Organizer: The 79th Japan Endocrine Society Meeting
  • Place of Presentation: Kobe
  • Year and Date: 2006-05-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Integration of intracellular signals in insulin granule exocytosis (2006)
  • Author(s): Seino S
  • Organizer: Nobel Minisymposium : Frontiers in Calcium Channel Research from Basics to Diseases
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2006-05-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Integration of intracellular signals in insulin granule exocytosis. (2006)
  • Author(s): Seino S
  • Organizer: Nobel Minisymposium : Frontiers in Calcium Channel Research from Basics to Diseases.
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2006-05-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膵β細胞の生物学 (2005)
  • Author(s): 清野 進
  • Organizer: 第17回高遠・分子細胞生物学シンポジウム
  • Place of Presentation: 長野
  • Year and Date: 20050818-20050819
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Sui β-saibou no seibutsugaku (2005)
  • Author(s): Seino S
  • Organizer: The 17th Takato Molecular Cellular Biology Symposium
  • Place of Presentation: Nagano
  • Year and Date: 20050818-20050819
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Bunpitsu saibou kenkyuu no atarashii kokoromi : Rab tanpakushitu hyouteki bunshi Noc2 idensi kesson ga naibunpitsu saibou to gaibunpitsu saibou ni oyobosu eikyou. (2005)
  • Author(s): Iwanaga T, Teramae H, Nio J
  • Organizer: The 110th Annual Meeting of the Japanese Association of Anatomists
  • Place of Presentation: Toyama
  • Year and Date: 20050529-20050531
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 分泌細胞研究の新しい試み: Rab蛋白標的分子Noc2遺伝子欠損が内分泌細胞と外分泌細胞に及ぼす影響 (2005)
  • Author(s): 岩永敏彦, 他
  • Organizer: 第110回日本解剖学会総会
  • Place of Presentation: 富山
  • Year and Date: 20050329-20050331
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Beta cell signaling (2005)
  • Author(s): Seino S
  • Organizer: The Donald F. Steiner Symposium
  • Place of Presentation: Chicago, USA
  • Year and Date: 2005-07-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Beta cell signaling. (2005)
  • Author(s): Seino S
  • Organizer: The Donald F Steiner Symposium.
  • Place of Presentation: Chicago, USA
  • Year and Date: 2005-07-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The integration of intracellular signals in regulated exocytosis : the pancreatic β-cell model (2005)
  • Author(s): 清野進
  • Organizer: 第58回日本細胞生物学会大会
  • Place of Presentation: 大宮
  • Year and Date: 2005-06-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The integration of intracellular signals in regulated exocytosis : the pancreatic β-cell model. (2005)
  • Author(s): Seino S
  • Organizer: The 58th Annual Meeting of the Japan Society for Cell Biology
  • Place of Presentation: Omiya
  • Year and Date: 2005-06-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular mechanism of cAMP-regulated insulin granule exocytosis. (2005)
  • Author(s): Shibasaki T, Seino S
  • Organizer: The 82nd Annual Meeting of Physiological Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 2005-05-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Molecular Mechanism of cAMP-regulated Insulin Granule Exocytosis (2005)
  • Author(s): Shibasaki T, Seino S
  • Organizer: 第82回日本生理学会大会
  • Place of Presentation: 仙台
  • Year and Date: 2005-05-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 糖尿病に対する再生医療の展望 (2005)
  • Author(s): 清野進
  • Organizer: 第48回日本糖尿病協会総会及び年次集会
  • Place of Presentation: 神戸
  • Year and Date: 2005-05-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Tounyoubyou ni taisuru saisei iryou no tenbou (2005)
  • Author(s): Seino S
  • Organizer: The 48th Annual Meeting of the Japan Diabetes Association
  • Place of Presentation: Kobe
  • Year and Date: 2005-05-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膵β細胞研究の新展開 (2005)
  • Author(s): 清野 進
  • Organizer: 第71回日本糖尿病学会中部地方会
  • Place of Presentation: 岐阜
  • Year and Date: 2005-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Sui β-saibou no shintenkai. (2005)
  • Author(s): Seino S
  • Organizer: The 71st Annual Meeting of the Japan Diabetes Society, Chubu Branch
  • Place of Presentation: Gifu
  • Year and Date: 2005-03-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膵β細胞研究と糖尿病. (2005)
  • Author(s): 清野進
  • Organizer: 第11回日本糖尿病眼学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2005-03-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Sui β-saibou kenkyu to tounyoubyou (2005)
  • Author(s): Seino S
  • Organizer: The 11th Annual Meeting of the Japanese Society of Ophthalmic Diabetology
  • Place of Presentation: Nagoya
  • Year and Date: 2005-03-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 糖尿病モデル動物による膵β細胞機能解析. (2005)
  • Author(s): 清野進
  • Organizer: 第19回日本糖尿病動物研究会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2005-02-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Tounyoubyou model doubutsu niyoru sui β-saibou kinou kaiseki (2005)
  • Author(s): Seino S
  • Organizer: The 19th Japan Association of Animal Diabetes Research
  • Place of Presentation: Kyoto
  • Year and Date: 2005-02-04
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] インスリン分泌システムの形成とその破綻 (2004)
  • Author(s): 清野進
  • Organizer: 第22回内分泌・代謝学サマーセミナー
  • Place of Presentation: 淡路
  • Year and Date: 20040819-20040824
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Insulin bunpitsu system no keisei to sono hatan (2004)
  • Author(s): Seino S
  • Organizer: The 22nd JES Summer Seminar on Endocrinology and Metabolism
  • Place of Presentation: Awaji
  • Year and Date: 20040819-20040821
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis (2004)
  • Author(s): 清野進
  • Organizer: 第81回日本生理学会大会 Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion
  • Place of Presentation: 札幌
  • Year and Date: 20040602-20040604
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis. (2004)
  • Author(s): Seino S
  • Organizer: The 81st Annual Meeting of the Physiological Society of Japan, Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion
  • Place of Presentation: Sapporo
  • Year and Date: 20040602-20040604
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mechahisms of insulin secretion (2004)
  • Author(s): Seino S
  • Organizer: Pioneers in Physiological Research and Challenges for 21^<st>Century Physiologists, Special Symposium
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2004-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ATP-sensitive (K_<ATP>)channel as the molecular target of sulfonylurea : its physiology and pathophysiologv (2004)
  • Author(s): Seino S
  • Organizer: The Research Symposium of Korean Diabetes Association, special Seminar
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2004-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ATP-sensitive (K_<ATP>) channel as the molecular target of sulfonylurea : its physiology and pathophysiology. (2004)
  • Author(s): Seino S
  • Organizer: The Research Symposium of Korean Diabetes Association, Special Seminar
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2004-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Mechanisms of insulin secretion. (2004)
  • Author(s): Seino S
  • Organizer: Pioneers in Physiological Research and Challenges for 21st Century Physiologists, Special Symposium.
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2004-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膵β細胞の生物学 - インスリン分泌システムの形成機構 (2004)
  • Author(s): 清野進
  • Organizer: 文部科学省特定領域研究-アディポミクス、脂肪細胞の機能世界と破綻病態の解明公開シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2004-10-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Sui β-saibou no seibutsugaku - insulin bunpitsu system no keisei kikou. (2004)
  • Author(s): Seino S
  • Organizer: Adipomics, Open symposium, Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Culture, Sports, Science, and Technology
  • Place of Presentation: Osaka
  • Year and Date: 2004-10-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Integration of intracellular signals in insulin granule exocytosis (2004)
  • Author(s): Seino S
  • Organizer: Diabetes Endocrinology Research Center, University of Washington, Special Symposium : Cellular Aspects of Insulin Secretion and Insulin Action
  • Place of Presentation: Seattle, USA
  • Year and Date: 2004-09-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Integration of intracellular signals in insulin granule exocytosis. (2004)
  • Author(s): Seino S
  • Organizer: Diabetes Endocrinology Research Center, University of Washington, Special Symposium : Cellular Aspects of Insulin Secretion and Insulin Action
  • Place of Presentation: Seattle, USA
  • Year and Date: 2004-09-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis (2004)
  • Author(s): Seino S
  • Organizer: The 81st Annual Meeting of the Physiological Society of Japan, Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion
  • Place of Presentation: 札幌
  • Year and Date: 2004-06-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Integration of stimulus-secretion coupling in insulin granule exocytosis. (2004)
  • Author(s): Seino S
  • Organizer: Second Korea-Japan Joint Symposium : Endocrine and Exocrine Secretion.
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 2004-06-04
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] インスリン分泌の分子構造 (2004)
  • Author(s): 清野進
  • Organizer: 第47回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
  • Year and Date: 2004-05-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Insulin bunpitsu no kouzou. (2004)
  • Author(s): Seino S
  • Organizer: The 47th Annual Meeting of the Japan Diabetes Society
  • Place of Presentation: Yokohama
  • Year and Date: 2004-05-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The biology of K_<ATP> channels : Emphasis on Kir (2004)
  • Author(s): Seino S
  • Organizer: The 5th International group on insulin secretion Symposium
  • Place of Presentation: St. Jean-Cap-Ferrat, France
  • Year and Date: 2004-03-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The biology of K_<ATP> channels : Emphasis on Kir. (2004)
  • Author(s): Seino S
  • Organizer: The 5th Servier-IGIS Symposium.
  • Place of Presentation: St. Jean-Cap-Ferrat, France.
  • Year and Date: 2004-03-18
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Evolution of Type II Diabetes and Obesity Marketplace to the year 2020 (2004)
  • Author(s): 清野進
  • Organizer: Key Opinion Leader Advisory Board
  • Place of Presentation: 東京
  • Year and Date: 2004-02-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Evolution of Type II Diabetes and Obesity Marketplace to the year 2020. (2004)
  • Author(s): Seino S
  • Organizer: Key Opinion Leader Advisory Board.
  • Place of Presentation: Tokyo
  • Year and Date: 2004-02-02
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Integration of ATP, cAMP and Calcium Signaling in Insulin Secretion (2004)
  • Author(s): Seino S
  • Organizer: International Symposium on Pathogenesis of Diabetes Mellitus
  • Place of Presentation: 神戸
  • Year and Date: 2004-01-08
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Integration of ATP, cAMP and calcium signaling in insulin secretion. (2004)
  • Author(s): Seino S
  • Organizer: International Symposium on Pathogenesis of Diabetes Mellitus.
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2004-01-08
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 形態学から見た消化管における内分泌・外分泌の特殊性と普遍性 : すべては消化管から始まった (2003)
  • Author(s): 岩永敏彦
  • Organizer: 第7回小児分子内分泌研究会
  • Place of Presentation: 富良野
  • Year and Date: 20030712-20030713
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] keitaigaku kara mita syoukakan ni okeru naibunpitsu gaibunpitsu no tokusyusei to huhensei subeteha syoukakan kara hajimmata. (2003)
  • Author(s): Iwanaga T
  • Organizer: Society for pedeatric molecular endocrinology.
  • Place of Presentation: Furano
  • Year and Date: 20030712-20030713
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] SU剤の標的分子K_<ATP>チャネル-新しい展開- (2003)
  • Author(s): 清野 進
  • Organizer: 第46回日本糖尿病学会年次学術集会
  • Place of Presentation: 富山
  • Year and Date: 20030522-20030524
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] SU zai no hyouteki bunshi K_<ATP> channel -atarashii tenkai-. (2003)
  • Author(s): Seino S
  • Organizer: The 46th Annual Meeting of the Japan Diabetes Society
  • Place of Presentation: Toyama
  • Year and Date: 20030522-20030524
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Positional cloning of the autoimmune type 1 diabetes gene in the KDP rat (2003)
  • Author(s): Yokoi N, Seino S
  • Organizer: Cold Spring Harbor Laboratory Winter Biotechnology Conference on Rat Genomics and Models
  • Place of Presentation: Cold spring Harbor, USA
  • Year and Date: 2003-12-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Positional cloning of the autoimmune type 1 diabetes gene in the KDP rat. (2003)
  • Author(s): Yokoi N, Seino S
  • Organizer: Cold Spring Harbor Laboratory Winter Biotechnology Conference on Rat Genomics and Models.
  • Place of Presentation: Cold Spring Harbor, USA
  • Year and Date: 2003-12-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Involvement of Piccolo/cAMP-GEFII/Rim2 Complex in cAMP-dependent Insulin Secretion (2003)
  • Author(s): Shibasaki T, et al.
  • Organizer: 第76回日本生化学会大会
  • Place of Presentation: 横浜
  • Year and Date: 2003-10-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Involvement of Piccolo/cAMP-GEFII/Rim2. Complex in cAMP-dependent Insulin Secretion. (2003)
  • Author(s): Shibasaki T, Fujimoto K, Yokoi N, Seino S
  • Organizer: The 76th Annual Meeting of Japanese Biochemical Society
  • Place of Presentation: Yokohama
  • Year and Date: 2003-10-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Classical and novel effectors (2003)
  • Author(s): Seino S
  • Organizer: The18th International Diabetes Federation Congress, Symposium : Normal β-cell stimulus-secretion coupling
  • Place of Presentation: Paris, France
  • Year and Date: 2003-08-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Classical and novel effectors. (2003)
  • Author(s): Seino S
  • Organizer: The 18th International Diabetes Federation Congress, Symposium : Normal β-cell stimulus-secretion coupling.
  • Place of Presentation: Paris, France
  • Year and Date: 2003-08-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 1型糖尿病モデルKDPラットにおける感受性遺伝子のポジショナルクローニング (2003)
  • Author(s): 横井伯英, 他
  • Organizer: 第46回日本糖尿病学会年次学術集会
  • Place of Presentation: 富山
  • Year and Date: 2003-05-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Ichigata tounyoubyou model KDP rat ni okeru kanjyusei idenshi no positional cloning. (2003)
  • Author(s): Yokoi N, Seino S
  • Organizer: The 46th Annual Meeting of the Japan Diabetes Society
  • Place of Presentation: Toyama
  • Year and Date: 2003-05-23
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Sui β-saibou shougai no bunshi kikou (0)
  • Author(s): Seino S
  • Organizer: Advances in Diabetology 41st Annual Post Graduate Course
  • Place of Presentation: sapporo
  • Year and Date: 00000929
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] PKA-independent mechanism of cAMP in insulin secretion. Pancreatic Beta Cell in Health and Disease. Seino S and Bell GI (eds.) (2008)
  • Author(s): Seino S, et al. (分担執筆)
  • Total Pages: 133-146
  • Publisher: springer
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 自然発症1型糖尿病動物の原因遺伝子. 糖尿病学基礎と臨床(編集 : 門脇孝、石橋俊、佐倉宏、戸邉一之、野田光彦) (2007)
  • Author(s): 横井伯英, 他(分担執筆)
  • Total Pages: 291-293
  • Publisher: 西村書店
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 膵腺房細胞の分化転換によるインスリン分泌細胞の作出. 糖尿病学2007(編集 : 岡芳知、谷澤幸生) (2007)
  • Author(s): 南幸太郎, 他(分担執筆)
  • Total Pages: 4-91
  • Publisher: 診断と治療社
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 膵腺房細胞の分化転換によるβ細胞再生の可能性. 分子糖尿病学の進歩 基礎から臨床まで-2007(監修 : 矢崎義雄、編集 : 清野 進、渥美義仁、門脇 孝、春日雅人) (2007)
  • Author(s): 南幸太郎, 他(分担執筆)
  • Total Pages: 22-26
  • Publisher: 金原出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] cAMPコンパートメントとインスリン分泌. 分子糖尿病学の進歩 基礎から臨床まで-2006(監修: 矢崎義雄、編集: 清野 進、渥美義仁、門脇 孝、春日雅人) (2006)
  • Author(s): 柴崎忠雄, 他(分担執筆)
  • Total Pages: 2-7
  • Publisher: 金原出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Kir6.1, Kir6.2 NC-IUPHAR subcommittee on potassium channels: Kir Group. The IUPHAR Compendium of Voltage-gated Ion Channels 2005. Catterall WA, Chandy KG, and Gutman GA(eds. ) (2005)
  • Author(s): Seino S (分担執筆)
  • Publisher: IUPHAR Media
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 消化管の正常組織像 消化器疾患診療実践ガイド(編集 : 千葉 勉、井廻道夫) (2005)
  • Author(s): 岩永敏彦(分担執筆)
  • Total Pages: 872-882
  • Publisher: 文光堂
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 腸管細胞形態観察法-「光学顕微鏡による観察」および「電子顕微鏡による観察法」. 生物化学実験法50 腸管細胞機能実験法(編集 : 上野川修一、清水 誠、八村敏志、戸塚 護) (2005)
  • Author(s): 岩永敏彦(分担執筆)
  • Total Pages: 7-21
  • Publisher: 学会出版センター
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 膵β細胞におけるグルコース応答性と細胞内カルシウム. 分子糖尿病学の進歩 基礎から臨床まで-2003 (監修 : 矢崎義雄、編集 : 清野 進、渥美義仁、門脇 孝、春日雅人) (2003)
  • Author(s): 南幸太郎, 他(分担執筆)
  • Total Pages: 17-22
  • Publisher: 金原出版
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] Noc2ノックアウトマウス (2004)
  • Inventor(s): 清野進, 三木隆司, 岩永俊彦, 松本正成
  • Industrial Property Rights Holder: 京都大学, 日本ケミカルリサーチ
  • Industrial Property Number: 特許権、特願2004-110374
  • Filing Date: 2004-04-02
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] インスリン分泌細胞の誘導 (2004)
  • Inventor(s): 清野 進, 南幸太郎, 奥野正顕, 宮脇一真
  • Industrial Property Rights Holder: 京都大学, 日本ケミカルリサーチ
  • Industrial Property Number: 特許権、特願2004-165367
  • Filing Date: 2004-06-03
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 遺伝子改変動物の新規用途 (2004)
  • Inventor(s): 清野 進, 三木隆司, 尾山和信
  • Industrial Property Rights Holder: 神戸大学, 武田薬品工業株式会社
  • Industrial Property Number: 特許権、特願2004-313063
  • Filing Date: 2004-10-27
  • Description: 「研究成果報告書概要(和文)」より