2006 Fiscal Year Final Research Report Summary
Cell adhesion machine-associated signaling mechanisms regulating cell behavior
| Project/Area Number |
15002014
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | RIKEN |
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Principal Investigator |
TAKEICHI Masatoshi RIKEN, Center for Developmental Biology, Group Director, 高次構造形成研究グループ, グループディレクター (00025454)
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| Co-Investigator(Kenkyū-buntansha) |
MAEKAWA Midori RIKEN, Center for Developmental Biology, Research Scientist, 高次構造形成研究グループ, 専門職研究員 (70314185)
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| Project Period (FY) |
2003 – 2006
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| Keywords | cadherin / catenin / cell adhesion / synapse / actin / Rho GEF / NMDA receptor / neuron |
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| Research Abstract |
1) αN-catenin is a cadherin-associated protein. We found that this protein is essential for the stability of synaptic contacts in hippocampal neurons.
2) Fat1 is a member of the cadherin superfamily. We showed that this large non-classic cadherin is localized at the basal portions of cell-cell contact, and regulates actin polymerization via its binding to Ena/VASP proteins.
3) We identified the role of the Cdc42-specific Rho GEF "Tuba". This enzyme regulates tension of cell-cell junctions, acting upstream of the Cdc42-N-WASP signaling pathway.
4) We discovered an unexpected movement of cadherin molecules at cell junctions, which was designated as "cadherin flow". This flow is mediated by retrograde actin flow, which also occurs at cell-cell contact sites.
5) We disclosed a novel signaling pathway for gene transcription in hippocampal neurons. Activation of the NMDA receptor resulted in N-terminal truncations of β-catenin, and the cleaved β-catenin was translocated into nuclei This process subsequently activated expression of the Fral gene. We also showed that this gene activation system also occurs in vivo.
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Research Products
(40 results)
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[Journal Article] N-cadherin mediates cortical organization in the mouse brain.2007
Author(s)
Kadowaki, M., Nakamura, S., Machon, O., Krauss, S., Radice, G.L., Takeichi M
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Journal Title
Develop. Biol 304
Pages: 22-33
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Comichon-like Protein (CNIL) Facilitates Seaetion of HB-EGF and Regulates Proper Development of Cranial Naves.2007
Author(s)
Hoshino, H, Uchida, T., Otsuki T., Kawamoto, S., Okubo, K, Takeichi, M., Chisaka, O.
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Journal Title
Mol Biol. Cell. 18
Pages: 1143-1152
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cadherin-11 in synovial lining formation and pathology in arthritis.2007
Author(s)
Lee, D.M, Kiener, H.P., Agarwal, S.K, Noss, E.H., Watts, G.F., Chisaka, O, Takeichi, M, Brenner, M.B.
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Journal Title
Science 315
Pages: 1006-1010
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery.2006
Author(s)
Togashi, H, Miyoshi, J., Honda, T., Sakisaka, T., Takai, T., Takeichi, M.
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Journal Title
J. Cell Biol. 174
Pages: 141-151
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Cadherin is required for dendritic morphogenesis and synaptic terminal organization of retinal horizontal cells.2006
Author(s)
Tanabe, K, Takahashi, Y., Sato, Y., Kawakami, K, Takeichi, M., Nakagawa, S.
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Journal Title
Development 133
Pages: 4085-4096
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Distribution of OL-protocadherin in axon fibers in the developing chick nervous system.2005
Author(s)
Nakao, S., Uemura, M., Aoki, E., Suzuki, S.T., Takeichi, M, Hirano, S.
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Journal Title
Brain Res. Mol. Brain Res. 134
Pages: 294-308
Description
「研究成果報告書概要(欧文)」より
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