2006 Fiscal Year Final Research Report Summary
Immune Surveillance, Its cellular and molecular basis, regulation and maintenance
| Project/Area Number |
15078101
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | RIKEN (2004-2006)
Kyushu University (2003) |
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Principal Investigator |
WATANABE Takeshi RIKEN, Immune Surveillance Research Unit, Unit Leader, 免疫監視機構研究ユニット, ユニットリーダー (40028684)
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| Co-Investigator(Kenkyū-buntansha) |
MINATO Naeahiro Kyoto University, Graduate School of Biostudies, Professor, 大学院生命科学研究科, 教授 (40137716)
MATSUSHIMA Koji University of Tokyo, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (50222427)
SAITO Takashi Laboratory for Cell Signaling, Group Leader, 免疫シグナル研究グループ, グループディレクター (50205655)
KOYASU Shigeo Keio University, School of Medicine, Professor, 医学部, 教授 (90153684)
YAMAMOTO Kazuhiko University of Tokyo, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 (80191394)
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| Project Period (FY) |
2003 – 2006
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| Keywords | immune surveillance / spatio-temporal regulation / thymus, bone marrow, lymph nodes / recognition and diversity / memory / signal transduction / autoimmune diseases / regeneration, |
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| Research Abstract |
The concept of "Immune Surveillance" was first proposed almost 50 years ago as a mechanism for elimination of nascent cancer cells before they develop into clinically evident tumors. However, the fundamental nature of this concept has not yet been fully clarified at either the cellular or molecular level, even though remarkable progress has been made in tumor immunology. Not only in the control of cancer, Immune Surveillance system plays a crucial role in the prevention of severe infection as well as the regulation of autoreactive immune responses. The objective of this special project is to broadly develop the basic research concerning the structural basis of the immune surveillance system in mice and humans, the regulation and maintenance of the surveillance network, and its clinical significance.
Year 2006 was the last year of this 4-years-term project on the Immune Surveillance Mechanism. As one of the activities of the "Summation Group (Sokatsu-han)", we especially promoted the interaction between researchers in order to facilitate their research activities on the clarification of the cellular and molecular basis of immune surveillance mechanism as well as invention to repair and reinforcement of the surveillance in our body. During 2006, over 200 papers were published. Among them, 30 papers were published in Journals of IF : over 20, and 60 papers in Journals of IF :10-20. We held the Second International Symposium on the Immune Surveillance at Tokyo on February 14, 15, 2007. We invited 11 foreign speakers from US and Europe who have been extensively developing their research on immune surveillance. It was very successful. During 4 years, 600 papers were published. Among them, 205 papers were reported in the Journals of IF : over 10. Over 50 patents were applied. We held 3 major symposia including 2 international symposia.
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Research Products
(59 results)
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[Journal Article] Intestinal tumors inactivated in TGF-b signaling secrete CCL9 and recruit CCR1+ myeloid cells that help invasion.2007
Author(s)
Kitamura, T., Kometani, K., Hashiba, H., Matsunaga, A., Miyoshi.Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, N, Taketo, M.
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Journal Title
Nature Gen. 39
Pages: 467-475
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] PD-Ll and tumor-infiltrating CD8+ T lymphocytes are independent prognostic factors of human ovarian cancer.2007
Author(s)
Hamanishi J., Mandai, M., Iwasaki, M., Okazaki.T., Tanaka, Y.Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K, Minato, N., Honjo, 1, Fujii, S.
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Journal Title
Proc. Natl. Acad. Sci. USA. 104
Pages: 3360-3365
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Medullary thymic epithelial cells expressing Aire represent ; unique lineage derived from claudin-expressing cells.2007
Author(s)
Hamazaki, Y, Fujita, H, Kobayashi, T, Choi, Y, H. Scott, Matsumoto, M, Minato, N.
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Journal Title
INature Immunol. 8
Pages: 304-311
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Role of SPA-1 in phenotypes of CML induced by BCR-ABL-expressing hematopoietic progenitors in mouse model.2006
Author(s)
Kometani, K., Kawamata, S., Shinozuka, Y., Era, T., Taniwaki, M., Hattori.M., Minato, N.
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Journal Title
Cancer Res. 66
Pages: 9967-9976
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] BCR/ABL and IL-3 activate Rap1 to stimulateB-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion.2006
Author(s)
Jin, A., Kurosu, T., Tsuji, K., Mizuchi, D., Arai, A., Fujita, H., Hattori, M., Minato, N., Miura, 0.
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Journal Title
Oncogene 20
Pages: 4332-4340
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Involvement of CD166 in the activation of human yS T cells by tumor cells sensitized with nonpeptide antigens.2006
Author(s)
Kato, Y., Tanaka, Y., Hayashi, M., Kita, S., Okawa, K., Minato, N.
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Journal Title
Mmmunol. 177
Pages: 877-884
Description
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[Journal Article] Mechanistic basis of pre-T cell receptor-mediated autonomous signaling critical for thymocyte development.2006
Author(s)
Yamasaki, S.Ishikawa, E., Sakuma, M., Ogata, K., Sakata-Sogawa, K., Hiroshima, M., Wiest, D.L., Tokunaga, M., Saito, T.
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Journal Title
Nat Immunol. 7(1)
Pages: 67-75
Description
「研究成果報告書概要(欧文)」より
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