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2004 Fiscal Year Annual Research Report

アディポミクス、脂肪細胞の機能世界と破綻病態の解明

Research Project

Project/Area Number 15081101
Research InstitutionOsaka University

Principal Investigator

松澤 佑次  大阪大学, 医学系研究科, 名誉教授 (70116101)

Co-Investigator(Kenkyū-buntansha) 船橋 徹  大阪大学, 医学系研究科, 講師 (60243234)
斉藤 昌之  北海道大学, 獣医学研究科, 教授 (80036441)
矢田 俊彦  自治医科大学, 医学研究科, 教授 (60166527)
Keywords内臓脂肪 / アディポサイトカイン / 脂肪細胞 / 発現遺伝子 / 分化
Research Abstract

本プロジェクトは「食」というヒトを含む動物の根元的事象と深く関わりながら、これまであまり研究されてこなかった脂肪脂肪の起源や生命装置、特にアディポサイトカインと呼ぶ内分泌機能などの機能世界を明らかにする「アディポミクス」という新分野を確立し、脂肪細胞機能の破綻という観点から、動脈硬化、糖尿病、癌を初めとする過栄養が関与するとされる疾患群の病態メカニズムや治療戦略を、多数の研究分野から研究者を結集して取り組み、「脂肪細胞ワールド」の全貌を明らかにしようとするものである。
平成15年度の活動成果により、平成16年度は21の公募研究が採択され、さらなる活性化が行われた。これらの成果とさらなる研究の発展を鑑み、1、平成16年10月1日に、一般に向け公開シンポジウム『驚異の脂肪細胞・生体防御機能から病態発症まで』を大阪大学中之島センターにおいて開催した。200名の会場は満席となり立ち見も出た。シンポジウムでは班員代表による成果の発表に加え、PE Scherer教授による脂肪細胞分泌因子の研究、評価委員である清野教授による分泌システム形成機構の講演がおこなわれ、シンポジウム参加者、班員にインパクトを与えた。2、翌2日には総括班会議を行った。計画班の研究遂行状況を確認し、新たな公募研究の研究計画と進行状況が発表された。タイトなスケジュールであったが濃密な討論が行われた。班全体の研究の進行についても討論され、着実に進行していることが確認された。3、本年度成果も英語版業績集を作成し、世界的に公表しうる形とし、さらなる班員相互の研究活性化にも繋げた。4、ホームページを用い、公開シンポジウムの案内や班員の連絡に活用した。立ち上げた。5、班全体が大きなものとなり活性化したが、特任研究員の働きにより、公開シンポジウムの企画、調整や業績集の編纂などが円滑かつ迅速に行われた。

  • Research Products

    (115 results)

All 2005 2004 Other

All Journal Article (108 results) Book (1 results) Patent(Industrial Property Rights) (6 results)

  • [Journal Article] Generation of Globular Fragment of Adiponectin by Leukocyte Elastase Secreted by Monocytic Cell Line TIP-1.2005

    • Author(s)
      Waki H., Yamauchi T, et al.
    • Journal Title

      Endocrinology. 146

      Pages: 790-796

  • [Journal Article] Osmotin is a Homolog of Human Adiponectin and Controls Apoptosis in Yeast Through a Homolog of Human Adiponectin Receptor.2005

    • Author(s)
      Narasimhan LM., Yamauchi T., et al.
    • Journal Title

      Molecular Cell. 17

      Pages: 171-180

  • [Journal Article] Kruppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation.2005

    • Author(s)
      Oishi Y, Yamauchi T., et al.
    • Journal Title

      Cell Metabolism. 1

      Pages: 27-39

  • [Journal Article] Deletion of Cdknlb ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice.2005

    • Author(s)
      Uchida T., Sakaue H., et al.
    • Journal Title

      Nat Med. 11・2

      Pages: 178

  • [Journal Article] Role of Kruppel-like factor 15 in PEPCK gene expression in the liver.2005

    • Author(s)
      Teshigawara K., Ogawa W., Sakaue H., et al.
    • Journal Title

      Biochem Biophys Res Commun. 327・3

      Pages: 920

  • [Journal Article] Role of Kruppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis.2005

    • Author(s)
      Mori T, Sakaue H., et al.
    • Journal Title

      J.Biol.Chem. (In press)

  • [Journal Article] Possible endocrine control by follistatin 315 during liver regeneration based on changes of activin receptor after partial hepatectomy in rat.2005

    • Author(s)
      K Takamura., et al.
    • Journal Title

      Hepato-Gastroenterology. (In press)

  • [Journal Article] Activin and activin receptor expression changes in liver regeneration in Rat2005

    • Author(s)
      K Takamura., et al.
    • Journal Title

      J.Surgical Research. (In press)

  • [Journal Article] Isolation of two human fibroblastic cell populations with multiple but distinct potential of mesenchymal differentiation by ceiling culture of mature fat cells from subcutaneous adipose tissue.2005

    • Author(s)
      Miyazaki T., Toriyama K., Kobori M., Torii S., Kitagawa Y.
    • Journal Title

      Differentiation. 72・1(In press)

  • [Journal Article] Differential effect of green tea catechins on three endothelial cell clones isolated from rat adipose tissue and on human umbilical vein endothelial cells.2005

    • Author(s)
      Koparal TA., Yamaguchi H., Omae K., Torii S., Kitagawa Y.
    • Journal Title

      Cytotechnology. 44・1(In press)

  • [Journal Article] Synergistic activity of activin A and basic fibroblast growth factor on Tyrosine hydroxylase expression through ERK1/ERK2 MAPK signaling.2005

    • Author(s)
      Y.L.Bao et al.
    • Journal Title

      J.Endocrinology. (In press)

  • [Journal Article] Computed tomographic assessment of body fat in beagles.2005

    • Author(s)
      Ishioka K.
    • Journal Title

      Vet Raiol.Ultrasound. 46(In press)

  • [Journal Article] Diurnal variations of serum leptin in dogs : effects of fasting and re-feeding.2005

    • Author(s)
      Ishioka K.
    • Journal Title

      Vet.J. 169(In press)

  • [Journal Article] CCAAT/enhancer binding protein α maintains the ability of insulin-stimulated GLUT4 translocation in 3T3-C2 fibroblastic cells.2005

    • Author(s)
      M Fujimoto., H Masuzaki., et al.
    • Journal Title

      Biochim.Biophys.Acta. (in press)

  • [Journal Article] Statins suppress oxidized low-density lipoprotein-induced macrophage proliferation by inactivation of small G protein-p38 MAPK pathway.2005

    • Author(s)
      Senokuchi T., et al.
    • Journal Title

      J.Biol.Chem. (in press)

  • [Journal Article] AICAR, an activator of AMP-activated protein kinase, down-regulates the insulin receptor expression in HepG2 cells.2005

    • Author(s)
      Nakamaru K., et al.
    • Journal Title

      Biochem Biophys Res Commun. 328

      Pages: 447-453

  • [Journal Article] Enhanced expression of PDX-1 and Ngn3 by exendin-4 during b cell regeneration in STZ-treated mice.2005

    • Author(s)
      Kodama S., et al.
    • Journal Title

      Biochem Biophys Res Commun. 327

      Pages: 1170-1178

  • [Journal Article] Therapeutic potential of thiazolidinediones in actuation of peroxisome proliferator-activated receptor g for monocyte recruitment and endothelial regeneration.2005

    • Author(s)
      Tanaka T., Fukunaga Y., Itoh H., et al.
    • Journal Title

      Eur.J.Pharmacol. 508

      Pages: 255-265

  • [Journal Article] Association of visceral fat accumulation and plasma adiponectin with colorectal adenoma : evidence for participation of insulin resistance.2005

    • Author(s)
      Otake S., Kawata S., et al.
    • Journal Title

      Clin Cancer Res. (in press)

  • [Journal Article] Genetic subtypes of familial hemophagocytic lymphohistiocytosis : correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions.2005

    • Author(s)
      E Ishii., et al.
    • Journal Title

      Blood. (発表予定)

  • [Journal Article] X-ray crystallography study on ribosome recycling : The mechanism of binding and action of RRF on the large subunit.2005

    • Author(s)
      Wilson D.N., et al.
    • Journal Title

      EMBO J. 24

      Pages: 251-260

  • [Journal Article] Insulin/Foxol pathway regulates expression levels of adiponectin receptors and Adponectin sensitivity.2004

    • Author(s)
      Tsuchida A., Yamauchi T., et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 30817-30822

  • [Journal Article] Increased serum leptin protects from adiposity despite the increase glucose uptake in white adipose tissue in mice lacking p85 alph2004

    • Author(s)
      Terauchi Y., Yamauchi T., et al.
    • Journal Title

      Diabetes. 53

      Pages: 2261-2270

  • [Journal Article] Pio Reduces Islet Triglyceride Content and Restores Impaired Glucose-Stimulated Insulin Secretion in Heterozygous PPARg Mice on2004

    • Author(s)
      Matsui J., Yamauchi T., et al.
    • Journal Title

      Diabetes. 53

      Pages: 2844-2854

  • [Journal Article] Role of MAPK phosphatase-1 (MKP-1) in adipocyte differentiation.2004

    • Author(s)
      Sakaue H., et al.
    • Journal Title

      J.Biol.Chem. 279・38

      Pages: 9951

  • [Journal Article] A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.2004

    • Author(s)
      Yamamoto J., Ikeda Y., Sakaue H., et al.
    • Journal Title

      J.Biol.Chem. 279・17

      Pages: 16954

  • [Journal Article] Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.2004

    • Author(s)
      Inoue H., Ogawa W, Sakaue H., et al.
    • Journal Title

      Nat Med. 10・2

      Pages: 168

  • [Journal Article] Tumor-stromal interaction of human pancreatic cancer : acquired resistance to anticancerdrugs and proliferation regulation are dependent on extracellular matrix (ECM) proteins.2004

    • Author(s)
      H Miyamoto., et al.
    • Journal Title

      Pancreas. 28(1)

      Pages: 38-44

  • [Journal Article] Activins, myostatin and related TGF-beat family members as novel therapeutic targets2004

    • Author(s)
      K Tsuchida.
    • Journal Title

      Current Drug Targets-Immune, Endocrine & Metabolic Disorders. 4(2)

      Pages: 157-166

  • [Journal Article] Activin isoforms signal through type I receptor serine/threonine kinase ALK7.2004

    • Author(s)
      K Tsuchida., et al.
    • Journal Title

      Mol.Cell.Endo. 220(1-2)

      Pages: 59-65

  • [Journal Article] Novel factors in regulation of activin signaling.2004

    • Author(s)
      K Tsuchida., et al.
    • Journal Title

      Mol.Cell.Endo. 225(1-2)

      Pages: 59-65

  • [Journal Article] Heparin binds to the laminin alpha4 chain LG4 domain at a site different from that found for other laminins.2004

    • Author(s)
      Yamashita H., Beck K., Kitagawa Y.
    • Journal Title

      Journal of Molevular Biology. 335・5

      Pages: 1145-1149

  • [Journal Article] Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells : a new insight into adipocytokine-endothelial cell interactions.2004

    • Author(s)
      Kawanami D.
    • Journal Title

      Biochem Biophys Res Commun. 314・2

      Pages: 415-419

  • [Journal Article] Vasorin, a transforming growth factor β-binding protein expressed in vascular smooth muscle cells, modulates the arterial response to injury in vivo.2004

    • Author(s)
      Ikeda Y.
    • Journal Title

      Proc Natl Acad Sci USA. 101・29

      Pages: 10732-10737

  • [Journal Article] Endothelial PAS Domain Protein 1 Gene Promotes Angiogenesis Through the Transactivation of Both Vascular Endothelial Growth Factor and Its Receptor, Flt-1.2004

    • Author(s)
      Takeda N.
    • Journal Title

      Circ Res. 95・2

      Pages: 146-153

  • [Journal Article] Cloning of bovine MAIL and its mRNA expression in white blood cells Of Holstein cows.2004

    • Author(s)
      Yamaji D.
    • Journal Title

      Vet Immunol.Immunopath. 98

      Pages: 175-184

  • [Journal Article] Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic micein association with decreased production of adiponectin and leptin.2004

    • Author(s)
      Ohashi A.
    • Journal Title

      J.Nutr.Sci.Vitaminol. 50(In press)

  • [Journal Article] 脱共役蛋白質(UCP)によるエネルギー消費調節メカニズムとその意義2004

    • Author(s)
      猪熊健一
    • Journal Title

      現代医療 36

      Pages: 1815-1820

  • [Journal Article] Orexins (Hypocretins) directly interacts with neuropeptide Y, POMC and glucose-responsive neurons to regulate Ca^<2+> signaling in a reciprocal manner to leptin : orexigenic neuronal pathways in the mediobasal hypothalamus.2004

    • Author(s)
      Muroya S., Funahashi H., Yada T., et al.
    • Journal Title

      Eur.J Neurosci. 19

      Pages: 1524-1534

  • [Journal Article] Cytosolic Ca^<2+> responses to sub-picomolar and nanomolar PACAP in pancreatic β-cells are mediated by VPAC2 and PAC 1 receptors.2004

    • Author(s)
      Yamada H., Watanabe M., Yada T.
    • Journal Title

      Regulatory Peptides. 123

      Pages: 147-153

  • [Journal Article] PACAP deficiency reduces carbohydrate intake and PACAP activates NPY-containing neurons in the hypothalamic arcuate nucleus.2004

    • Author(s)
      Nakata M., Kohno D., Yada T., et al.
    • Journal Title

      Neruosci.Lett 370

      Pages: 252-256

  • [Journal Article] Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca^<2+> signaling in β-cells : implication in the glycemic control in rodents.2004

    • Author(s)
      Dezaki K., Yada T., et al.
    • Journal Title

      Diabetes. 53

      Pages: 3142-3151

  • [Journal Article] Inflammation, angiogenesis, and endothelial progenitor cells.2004

    • Author(s)
      Sata M., Nagai R.
    • Journal Title

      J.Mol.Cell.Cardiol. 36・4

      Pages: 459-463

  • [Journal Article] Statins augment collateral growth in response to ischemia but they do not Promote.2004

    • Author(s)
      Sata M., Nishimatsu H., et al.
    • Journal Title

      Hypertension. 43・6

      Pages: 1214-1220

  • [Journal Article] Origin of neointimal cells in autologous vein graft.2004

    • Author(s)
      Sata M., Nagai R.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 24・7

      Pages: 1147-1149

  • [Journal Article] Contribution of bone marrow derived cells to choroidal Neovascularization.2004

    • Author(s)
      Takahashi H., Yanagi Y., Tamaki Y., Muranaka K., Usui T., Sata M.
    • Journal Title

      Biochem Biophys Res Commun. 320・2

      Pages: 372-375

  • [Journal Article] Anti-monocyte chemoattractant protein-1 gene therapy attenuates graft vasculopathy.2004

    • Author(s)
      Saiura A., Sata M, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 24・10

      Pages: 1886-1890

  • [Journal Article] Temporal and spatial characterization of cellular constituents during neointimnal hyperplasia after vascular injury.2004

    • Author(s)
      Shoji M, Sata M., et al.
    • Journal Title

      Cardiovasc Pathol. 13・6

      Pages: 306-312

  • [Journal Article] Novel adipose tissue-mediated resistance to diet-induced visceral obesity in 11β-hydroxysteroid dehydrogenase type-1 deficient mice.2004

    • Author(s)
      N.M.Morton., H Masuzaki., et al.
    • Journal Title

      Diabetes. 53

      Pages: 931-938

  • [Journal Article] An angiotensin II AT 1 receptor antagonist, telmisartan augments glucose uptake and Glut 4 protein expression in 3T3-L1 adipocytes.2004

    • Author(s)
      M Fujimoto., H Masuzaki., et al.
    • Journal Title

      FEBS Lett. 576

      Pages: 492-497

  • [Journal Article] Antidiabetic and adipogenic properties of a newly-synthesized thiazolidine derivative, FPFS-410.2004

    • Author(s)
      N Norisada., H Masuzaki., et al.
    • Journal Title

      Metabolism. 53

      Pages: 1532-1537

  • [Journal Article] Efficacy of long-term leptin replacement therapy for lipoatrophic diabetes in Japan.2004

    • Author(s)
      K Ebihara., H Masuzaki., et al.
    • Journal Title

      N.Eng.J.Med. 351

      Pages: 615-616

  • [Journal Article] Association of Ob-R gene polymorphism and insulin resistance in Japanese men.2004

    • Author(s)
      A Yasuno., H Masuzaki., et al.
    • Journal Title

      Metabolism. 53

      Pages: 650-654

  • [Journal Article] Extracellular signal-regulated kinase and p38 mitogen-activated protein kinase mediate macrophage proliferation induced by oxidized low-density lipoprotein.2004

    • Author(s)
      Senokuchi T., et al.
    • Journal Title

      Atherosclerosis. 176

      Pages: 233-245

  • [Journal Article] 15d-PGJ2 inhibits oxidized LDL-induced macrophage proliferation by inhibition of GM-CSF production via inactivation of NF-κB.2004

    • Author(s)
      Matsuo T., et al.
    • Journal Title

      Biochem Biophys Res Commun. 314

      Pages: 817-823

  • [Journal Article] Overexpression of CNP in chondrocytes rescues achondroplasia through a MAPK-dependent pathway.2004

    • Author(s)
      A Yasoda., Y Komatsu., Y Ogawa., et al.
    • Journal Title

      Nat.Med. 10

      Pages: 80-86

  • [Journal Article] Serum leptin level is a regulator of bone mass.2004

    • Author(s)
      F Elefteriou., S Takeda., Y Ogawa., et al.
    • Journal Title

      Proc.Natl.Acad.Sci.USA. 101

      Pages: 3258-3263

  • [Journal Article] Gene and phenotype analysis of congenital generalized lipodystrophy in Japanese : a novel homozygous nonsense mutation in seipin gene.2004

    • Author(s)
      K Ebihara., T Kusakabe., Y Ogawa., et al.
    • Journal Title

      J.Clin.Endocrinol.Metab. 89

      Pages: 2360-2364

  • [Journal Article] Leptin stimulates ischemia-induced retinal neovascularization : possible role of vascular endothelial growth factor expressed in retinal endothelial cells.2004

    • Author(s)
      E Suganami., H Takagi., Y Ogawa., et al.
    • Journal Title

      Diabetes. 53

      Pages: 2443-2448

  • [Journal Article] Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients.2004

    • Author(s)
      N Satoh., M Naruse., Y Ogawa., et al.
    • Journal Title

      Diabetes Care. 27

      Pages: 2488-2490

  • [Journal Article] Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo.2004

    • Author(s)
      T Asaki., et al.
    • Journal Title

      Mol.Cell.Endocrinol. 214

      Pages: 119-128

  • [Journal Article] Evolution of the Fgf and Fgfr gene families.2004

    • Author(s)
      N Itoh., D.M.Ornitz.
    • Journal Title

      Trends in Genetics. 20

      Pages: 563-569

  • [Journal Article] Characterization of growth factor-binding structures in heparin/heparan sulfate using an octasaccharide library.2004

    • Author(s)
      S Ashikari-Hada., et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 12346-12354

  • [Journal Article] Biochemical analysis of mechanisms for craniofacial and limb abnormalities.2004

    • Author(s)
      O.A.Ibrahimi et al.
    • Journal Title

      Hum.Mol.Genet. 13

      Pages: 2313-2324

  • [Journal Article] A Kruppel-like factor KLF 15 Mediates Fasting-Induced Transcriptional Activation of Mitochondrial Acetyl-CoA synthetase gene, AceCS2.2004

    • Author(s)
      Yamamoto J., Sakai J., et al.
    • Journal Title

      Journal of Biological Chemistry. 279

      Pages: 16954-16962

  • [Journal Article] The very low-density lipoprotein (VLDL) receptor : characterization and functions as a peripheral lipoprotein receptor.2004

    • Author(s)
      Takahashi S., Sakai J., et al.
    • Journal Title

      Journal of Atherosclerosis and Thrombosis. 11

      Pages: 200-208

  • [Journal Article] Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis.2004

    • Author(s)
      Yu R., et al.
    • Journal Title

      Atherosclerosis. 174

      Pages: 35-42

  • [Journal Article] Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene express ion in isolated rat adipocytes.2004

    • Author(s)
      Tsuda T., et al.
    • Journal Title

      Biochem Biophys Res Commun. 316

      Pages: 149-157

  • [Journal Article] Capsaicin, a spicy component of hot pepper, inhibits the production of tumor necro sis factor alpha by LPS-stimulated murine macrophage Raw 264.7 : a PPARgamma ligand -like action of capsaicin as a npvel mechaniosm.2004

    • Author(s)
      Park J., et al.
    • Journal Title

      FEBS Letters. 572

      Pages: 266-270

  • [Journal Article] Red yeast rice extracts suppress adipogenesis by -down-regulating adipogenic transcription factors and gene expression in 3T3-L1 cells.2004

    • Author(s)
      Jeon T., et al.
    • Journal Title

      Life Sci. 75

      Pages: 3195-3203

  • [Journal Article] Platelet-derived growth factor stimulates glucose transport in skeletal muscles of transgenic mice specifically expressing PDGF receptor in the muscle, but does not affect blood glucose levels.2004

    • Author(s)
      Tomoyuki Yuasa., Kazuhiro Kishi., Yousuke Ebina., et al.
    • Journal Title

      Diabetes. 53

      Pages: 2776-2786

  • [Journal Article] KATP Channel Knockout Mice with transgenic Mice Expressing a Dominant-Negative Form of Human Insulin receptor have Glucose Intolerance but not Diabetes.2004

    • Author(s)
      Yoshiko Kanezaki,, Kazuhiro Kishi, Yousuke Ebina et al.
    • Journal Title

      Endocrine J. 51・2

      Pages: 133-144

  • [Journal Article] Demethylation of MAGE promoters during gastric cancer progression.2004

    • Author(s)
      Honda T., Kawata S., et al.
    • Journal Title

      Br J Cancer. 90

      Pages: 838-843

  • [Journal Article] Genetic variations in human associated with differences in the course of heapatitis C.2004

    • Author(s)
      Saito T., Kawata S., et al.
    • Journal Title

      Biochem Biophys Res Commun. 30

      Pages: 335-341

  • [Journal Article] Promoter hypermethylation of the Chfr gene in neoplastic and non-neoplastic gastric epithelia2004

    • Author(s)
      Honda T., Kawata S., et al.
    • Journal Title

      Br J Cancer. 90

      Pages: 2013-2016

  • [Journal Article] Characteristics of patients with chronic hepatitis C who develop hepatocellular carcinoma after a sustained response to interferon therapy.2004

    • Author(s)
      Makiyama A., Kawata S., et al.
    • Journal Title

      Cancer. 101

      Pages: 1616-1622

  • [Journal Article] Promoter hypermethyltion of DAP-kinase is associated with poor survival in primary biliary tract carcinoma patients.2004

    • Author(s)
      Tozawa T., Kawata S., et al.
    • Journal Title

      Cancer Sci. 95

      Pages: 736-740

  • [Journal Article] The important role for betaVLDLs binding at the fourth cysteine of first ligand-binding domain in the low-density lipoprotein receptor2004

    • Author(s)
      Iwasaki T., et al.
    • Journal Title

      J.Hum.Genet. 49

      Pages: 622-628

  • [Journal Article] Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family.2004

    • Author(s)
      Mashek.D.G., et al.
    • Journal Title

      J.Lipid Res. 45

      Pages: 1958-1961

  • [Journal Article] The very low-density lipoprotein (VLDL) receptor : characterization and functions as a peripheral lipoprotein receptor.2004

    • Author(s)
      Takahashi S., et al.
    • Journal Title

      J.Atheroscler Thromb. 11

      Pages: 200-208

  • [Journal Article] A Kruppel-like factor KLF15 contributes fasting-induced transcriptional activation of mitochondrial acetyl-CoA synthetase gene AceCS2.2004

    • Author(s)
      Yamamoto J., et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 16954-16962

  • [Journal Article] Interleukin (IL)-6, but not IL-1, induction in the brain downstream of cyclooxygenase-2 is essential for the induction of febrile response against peripheral IL-1alpha.2004

    • Author(s)
      Kagiwada K., Chida D., et al.
    • Journal Title

      Endocrinology. 145・11

      Pages: 5044-5048

  • [Journal Article] Deficiency of interleukin-1 receptor antagonist deteriorates fatty-liver and cholesterol metabolism in hypercholesterolemic mice.2004

    • Author(s)
      Isoda K, Sawada S., Ayaori M., Matsuki T., et al.
    • Journal Title

      J.Biol.Chem. (in press)

  • [Journal Article] Protein phosphatase 2Cα as a positive regulator of insulin sensitivity through direct.2004

    • Author(s)
      Yoshizaki T., Maegawa H., et al.
    • Journal Title

      J.Biol.Chem 279

      Pages: 22715-22726

  • [Journal Article] Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes.2004

    • Author(s)
      Ugi S., Imamura T., Maegawa H., et al.
    • Journal Title

      Mol Cell Biol. 24

      Pages: 8778-8789

  • [Journal Article] The peroxisome proliferator-activated receptor (PPAR) γ regulates expression of the perilipin gene in adipocytes.2004

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      Arimura N., et al.
    • Journal Title

      J.Biol.Chem 279

      Pages: 10070-10076

  • [Journal Article] Bile acid reduces the secretion o very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4.2004

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      Hirokane H., et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 45685-45692

  • [Journal Article] Muncl3-4 is a GTP-Rab27 binding protein regulating dense core granule secretion in platelets.2004

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      R Shirakawa., et al.
    • Journal Title

      Journal of Biological Chemistry. 279

      Pages: 10737-10790

  • [Journal Article] Stabilization mechanism of triple helical structure of collagen molecules.2004

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      Nishi Y., et al.
    • Journal Title

      Letters in Peptide Science. 10

      Pages: 533-537

  • [Journal Article] Stabilization of Triple Helical Structure of Collagen Molecule.2004

    • Author(s)
      Kobayashi Y., et al.
    • Journal Title

      Peptide Science. 2003

      Pages: 25-28

  • [Journal Article] Two States of the Triple Helix in the Thermal Transition of the Collagen Model Peptide (Pro-Pro-Gly)10.2004

    • Author(s)
      Kai T., et al.
    • Journal Title

      J.Biomol.Struct Dyn. 22

      Pages: 51-58

  • [Journal Article] Complete Thermal -Unfolding Profiles of Oxidized and Reduced Cytochromes C.2004

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      Uchiyama S., et al.
    • Journal Title

      J.Am.Chem.Soc. 126

      Pages: 14684-14685

  • [Journal Article] Solution Structure of Ribosomal Protein L16 from Thermus thermophilus HB8.2004

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      Nishimura M., et al.
    • Journal Title

      J.Mol.Biol. 344

      Pages: 1369-1383

  • [Journal Article] The novel gene fad158, having a transmembrane domain and leucine-rich repeat, stimulates adipocyte differentiation.2004

    • Author(s)
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    • Journal Title

      J.Biol.Chem. 279・33

      Pages: 34840-34848

  • [Journal Article] The novel gene fad104, containing a fibronectin type III domain, has a significant role in adipogenesis.2004

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    • Journal Title

      FEBS Lett. 577・1-2

      Pages: 49-54

  • [Journal Article] Fad24, a mammalian homolog of Noc3p, is a positive regulator inadipocyte differentiation.2004

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    • Journal Title

      J.Cell Sci. 117・25

      Pages: 6217-6226

  • [Journal Article] Enhanced insulin sensitivity, energy expenditure and thermogenesis in adipose-specific Pten suppression in mice.2004

    • Author(s)
      Komazawa N.
    • Journal Title

      Nature Medicine. 10・11

      Pages: 1208-1215

  • [Journal Article] Increased oxidative stress in obesity and its impact on metabolic syndrome.2004

    • Author(s)
      Furukawa S.
    • Journal Title

      Journal of Clinical Investigation. 114・12

      Pages: 1752-1761

  • [Journal Article] 脂肪細胞分化に関わる遺伝子発現制御ネットワーク2004

    • Author(s)
      今川 正良
    • Journal Title

      生化学 76・4

      Pages: 373-378

  • [Journal Article] Adiponectin-mediated modulation of hypertrophic signals in the heart.2004

    • Author(s)
      Shibata R.
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      Nat Med. 10(12)

      Pages: 1384-1389

  • [Journal Article] Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling.2004

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      Shibata R.
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      J Biol Chem. 279(27)

      Pages: 28670-28674

  • [Journal Article] Hypoadiponectinemia is an independent risk factor for hypertension.2004

    • Author(s)
      Iwashima Y.
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      Hypertension. 43(6)

      Pages: 1318-1323

  • [Journal Article] Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages.2004

    • Author(s)
      Kumada M.
    • Journal Title

      Circulation. 109(17)

      Pages: 2046-2049

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      Ohashi K.
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      J Am Coll Cardiol. 43(7)

      Pages: 1195-1200

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      Kobayashi H.
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      Circ Res. 94(4)

      Pages: e27-e31

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    • Journal Title

      Regulatory Peptides. (in press)

  • [Journal Article] Identification of the prolactin-releasing peptide-producing cell in the rat adrenal gland.

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      Fujiwara K., Matsumoto H., Yada T., Inoue K.
    • Journal Title

      Regulatory Peptides. (in press)

  • [Journal Article] Receptor-type protein tyrosine phosphatase ε (PTP ε M) is a negative regulator of insulin signaling in primary hepatocytes and liver.

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      Nakagawa., et al.
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      Zoological Science. (in press)

  • [Book] ホルモンと臨床 第52巻 第12号2004

    • Author(s)
      河野大輔, 矢田俊彦
    • Total Pages
      (1125)13-(1130)18
  • [Patent(Industrial Property Rights)] The Regulators Of Expression Of Adiponectin Receptors2004

    • Inventor(s)
      山内 敏正ら
    • Industrial Property Rights Holder
      山内 敏正ら
    • Industrial Property Number
      アメリカ(Provisional出願) 66/549,561
    • Filing Date
      2004-03-04
  • [Patent(Industrial Property Rights)] インスリン抵抗性の改善剤、及びそのスクリーニング方法2004

    • Inventor(s)
      春日 雅人, 阪上 浩, 中村 武寛, 松木 泰
    • Industrial Property Rights Holder
      国立大学法人神戸大学
    • Industrial Property Number
      特願2004-213582
    • Filing Date
      2004-07-21
  • [Patent(Industrial Property Rights)] フォリスタチン変異体ポリペプチド2004

    • Inventor(s)
      土田 邦博, 村上 達也
    • Industrial Property Rights Holder
      四国TLO協和発酵工業株式会社
    • Industrial Property Number
      特願2004-355293
    • Filing Date
      2004-12-08
  • [Patent(Industrial Property Rights)] 低血清培養で選択的に増殖する動物組織遍在性の他分化精細胞2004

    • Inventor(s)
      北川 泰雄 他7者
    • Industrial Property Rights Holder
      北川 泰雄 他3者
    • Industrial Property Number
      特願2004-201615
    • Filing Date
      2004-07-08
  • [Patent(Industrial Property Rights)] アディポネクチンプロモーター2004

    • Inventor(s)
      下村 伊一郎, 竹田 潤二, 駒沢 伸泰
    • Industrial Property Rights Holder
      下村 伊一郎, 竹田 潤二, (株)インテレクチャル・プロパティ・コンサルティング
    • Industrial Property Number
      特願2004-241497
    • Filing Date
      2004-08-20
  • [Patent(Industrial Property Rights)] 肥満の処置および予防のための方法および医薬ならびにそのスクリーニング法2004

    • Inventor(s)
      下村 伊一郎, 竹田 潤二, 駒沢 伸泰
    • Industrial Property Rights Holder
      下村 伊一郎, 竹田 潤二, (株)インテレクチャル・プロパティ・コンサルティング
    • Industrial Property Number
      特願2004-2577921
    • Filing Date
      2004-09-03

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Published: 2006-07-12   Modified: 2016-04-21  

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