2007 Fiscal Year Final Research Report Summary
Molecular mechanism of adipocyte proliferation and adipose tissue development
| Project/Area Number |
15081204
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
ITOH Nobuyuki Kyoto University, Graduate School of Pharmaceutical Sciences, Professor (10110610)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KONISHI Morichika Kyoto University, Graduate School of Pharmaceutical Sciences, Assistant Professor (00322165)
|
|---|
| Project Period (FY) |
2003 – 2007
|
| Keywords | Fibroblast Growth Factor / White Adipose Tissue / Tissue Formation / Differentiation / Cell proliferation / Obesity |
|---|
| Research Abstract |
Fibroblast Growth factors (Fgfs) are important intercellular signaling molecules. We elucidated the role of FGF signalings in the development of white adipose tissue (WAT). Analyses of Fgf10^<-/-> WAT have indicated that Fgf10 plays crucial roles in the proliferation of preadipocytes and their subsequent differentiation into mature adipocytes at embryonic stages. In addition, we found that Fgf receptor 2c potentially activated by Fgf9 plays a role in the adipocyte hypertrophy in the mesenteric WAT. Fgf21 was reported to be a metabolic regulator with multiple beneficial effects on glucose homeostasis and insulin sensitivity. We generated Fgf21^<-/-> mice to examine the physiological role of Fgf21. Increase in the weight of WAT and decrease in plasma FFA levels were observed in Fgf21^<-/-> mice. Our findings provide a novel insight into the development and function of WAT.
|
