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2007 Fiscal Year Final Research Report Summary

Molecular mechanism of adipocyte proliferation and adipose tissue development

Research Project

Project/Area Number 15081204
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

ITOH Nobuyuki  Kyoto University, Graduate School of Pharmaceutical Sciences, Professor (10110610)

Co-Investigator(Kenkyū-buntansha) KONISHI Morichika  Kyoto University, Graduate School of Pharmaceutical Sciences, Assistant Professor (00322165)
Project Period (FY) 2003 – 2007
KeywordsFibroblast Growth Factor / White Adipose Tissue / Tissue Formation / Differentiation / Cell proliferation / Obesity
Research Abstract

Fibroblast Growth factors (Fgfs) are important intercellular signaling molecules. We elucidated the role of FGF signalings in the development of white adipose tissue (WAT). Analyses of Fgf10^<-/-> WAT have indicated that Fgf10 plays crucial roles in the proliferation of preadipocytes and their subsequent differentiation into mature adipocytes at embryonic stages. In addition, we found that Fgf receptor 2c potentially activated by Fgf9 plays a role in the adipocyte hypertrophy in the mesenteric WAT. Fgf21 was reported to be a metabolic regulator with multiple beneficial effects on glucose homeostasis and insulin sensitivity. We generated Fgf21^<-/-> mice to examine the physiological role of Fgf21. Increase in the weight of WAT and decrease in plasma FFA levels were observed in Fgf21^<-/-> mice. Our findings provide a novel insight into the development and function of WAT.

  • Research Products

    (27 results)

All 2008 2007 2006 2005 2004 2003 Other

All Journal Article (11 results) (of which Peer Reviewed: 9 results) Presentation (14 results) Book (2 results)

  • [Journal Article] Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue2008

    • Author(s)
      Konishi, M., et al.
    • Journal Title

      Molecular and Cellular Endocrinology (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Functional evolutionary history of the mouse Fgf gene family2008

    • Author(s)
      Itoh, N., et al.
    • Journal Title

      Developmental Dynamics 237

      Pages: 18-27

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Brorin, a novel secreted BMP antagonist, promotes neurogenesis in mouse neural precursor cells.2007

    • Author(s)
      Koike, N., et al.
    • Journal Title

      Journal of Biological Chemistry 282

      Pages: 15843-15850

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Role of Fgf10 in cell proliferation in white adipose tissue.2006

    • Author(s)
      Konishi, M., et al.
    • Journal Title

      Molecular and Cellular Endocrinology 249

      Pages: 71-77

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Neudesin, a secreted factor, promotes neural cell proliferation and neuronal differentiation in mouse neural precursor cells.2006

    • Author(s)
      Kimura, I., et al.
    • Journal Title

      Journal of Neuroscience Research 83

      Pages: 1415-1424

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Regulation of mammalian tooth cusp patterning by ectodin2005

    • Author(s)
      Kassai, Y., et al.
    • Journal Title

      Science 309

      Pages: 2067-2070

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Neudesin, a novel secreted protein with a unique primary structure and neurotrophic activity2005

    • Author(s)
      Kimura, I., et al.
    • Journal Title

      Journal of Neuroscience Research 79

      Pages: 287-294

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Roles of fibroblast growth factor 10 (Fgf10) in adipogenesis in vivo.2004

    • Author(s)
      Asaki, T., et al.
    • Journal Title

      Molecular and Cellular Endocrinology 218

      Pages: 119-128

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Evolution of Fgf and Fgfr gene families2004

    • Author(s)
      Itoh, N., et al.
    • Journal Title

      Trends in Genetics 20

      Pages: 563-569

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Roles of fibroblast growth factor 10 (Fgf1O) in adipogenesis in vivo.2004

    • Author(s)
      Asaki, T., et al.
    • Journal Title

      Molecular and Cellular Endocrinology 218

      Pages: 116-128

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue

    • Author(s)
      Konishi, M., et al.
    • Journal Title

      Molecular and Cellular Endocrinology (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 腸間膜脂肪組織形成におけるFgf受容体2の役割の解明2007

    • Author(s)
      中村尋俊, 他
    • Organizer
      BMB2007(第30回日本分子生物学会年会 第80回日本生化学会大会 合同大会)
    • Place of Presentation
      パシフイコ横浜
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue2007

    • Author(s)
      Nakamura, H., et al.
    • Organizer
      BMB2007
    • Place of Presentation
      Pacifico Yokohama
    • Year and Date
      2007-12-13
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 腸間膜脂肪組織形成におけるFgfシグナリングの役割2006

    • Author(s)
      小西守周, 他
    • Organizer
      第27回肥満学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Role of Fgf signaling in the development of mesenteric white adipose tissue2006

    • Author(s)
      Konishi, M., et al.
    • Organizer
      27^<th> Annual Meeting of Japan Society for the Study of Obesity
    • Place of Presentation
      Kobe International Conference Center
    • Year and Date
      2006-10-28
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Fibroblast Growth Factor Receptor 2 is Necessary for Hypertrophy of Mature Adipocytes in Mesenteric White Adipose Tissue2006

    • Author(s)
      Konishi, M., et al
    • Organizer
      The 11^<th> Adiposcience Symposium
    • Place of Presentation
      千里阪急ホテル
    • Year and Date
      2006-08-19
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Fibroblast Growth Factor Receptor 2 is Necessary for Hypertrophy of Mature Adipocytes in Mesenteric White Adipose Tissue2006

    • Author(s)
      Konishi, M., et al.
    • Organizer
      The 11^<th> Adiposcience Symposium
    • Place of Presentation
      Senri Hankyu Hotel
    • Year and Date
      2006-08-19
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Fgf10による脂肪細胞分化、増殖におけるRbファミリーの役割2005

    • Author(s)
      小西守周, 他
    • Organizer
      第28回日本分子生物学会年会
    • Place of Presentation
      福岡Yahoo! JAPANドーム
    • Year and Date
      2005-12-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Role of pRbs in adipocyte proliferation and differentiation by Fgf102005

    • Author(s)
      Konishi, M., et al.
    • Organizer
      The 28^<th> Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Fukuoka Yahoo! JAPAN DOME
    • Year and Date
      2005-12-09
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Fgf10による脂肪細胞増殖機構の検討2004

    • Author(s)
      小西守周, 他
    • Organizer
      第27回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2004-12-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanism of Adipocyte Proliferation by Fgf102004

    • Author(s)
      Konishi, M., et al.
    • Organizer
      The 27^<th> Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe Port Island
    • Year and Date
      2004-12-09
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Fgf10の脂肪細胞増殖における役割2003

    • Author(s)
      小西守周, 他
    • Organizer
      第26回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2003-12-11
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Role of Fgf10 in Adipocyte Proliferation2003

    • Author(s)
      Konishi, M., et al.
    • Organizer
      The 26^<th> Annual Meeting of the Molecular Biology Society of Japan
    • Place of Presentation
      Kobe Port Island
    • Year and Date
      2003-12-11
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] In vivoにおける脂肪細胞分化のメカニズムの解明2003

    • Author(s)
      浅木敏之, 他
    • Organizer
      第8回アディポサイエンス研究会シンポジウム
    • Place of Presentation
      千里阪急ホテル
    • Year and Date
      2003-08-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanism of adipocyte differentiation in vivo2003

    • Author(s)
      Asaki, T., et al.
    • Organizer
      The 8^<th> Adiposcience Symposium
    • Place of Presentation
      Senri Hankyu Hotel
    • Year and Date
      2003-08-09
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 糖尿病カレントライブラリー7 脂肪細胞と脂肪組織2007

    • Author(s)
      小西守周, 他
    • Total Pages
      6-10
    • Publisher
      文光堂
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Tounyoubyou Current Library 7 Adipcytes and Adipose tissue2007

    • Author(s)
      Konishi, M., et al.
    • Total Pages
      6-10
    • Publisher
      BUNKODO CO., LTD.
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-06-09  

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