2007 Fiscal Year Final Research Report Summary
Analysis of Molecular Mechanisms that Monitor Hypertrophy of Adipocytes
| Project/Area Number |
15081205
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyoto University |
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Principal Investigator |
KAWADA Teruo Kyoto University, Graduate School of Agriculture, Professor (10177701)
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| Project Period (FY) |
2003 – 2007
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| Keywords | adipocyte / signal transduction / lipid / life style-related discase / obesity / metabolic syndrome |
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| Research Abstract |
The importance of analyzing the development (hypertrophy) of adipocytes and their pathologic regulatory mechanism has been indicated. In this study, on the basis of the responsiveness of adipocytes to intracellular signal transudation ions, we searched for and identified an intrachannel functional molecule in the membrane (monitor molecule) that regulates the development and hypertrophy of adipocytes in response to changes in their volume. To identify candidates, we performed a microarray analysis of gene expression in white adipose tissue from obese mice. We found that the expression level of one cation channel (CA-2) mRNA was increased significantly in white adipose tissue of obese mice and functioned on adipocyte development. These results suggest that CA-2 might play an important role on the monitor of adipocyte hypertrophy.
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