2007 Fiscal Year Final Research Report Summary
Novel signaling function of adipocytes
| Project/Area Number |
15081211
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Jichi Medical University |
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Principal Investigator |
YADA Toshihiko Jichi Medical University, School of Medicine, Professor (60166527)
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| Co-Investigator(Kenkyū-buntansha) |
NAKATA Masanori Jichi Medical University, School of Medicine, Associate Professor (10305120)
DEZAKI Katsuya Jichi Medical University, School of Medicine, Associate Professur (90337329)
MAEJIMA Yuko Jichi Medical University, School of Medicine, Assistant Professor (40438669)
TORIYA Masako Jichi Medical University, School of Medicine, 21st Century COE Program, post-doctral fellow (90420819)
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| Project Period (FY) |
2003 – 2007
|
| Keywords | visceral fat / leptin / resistin / fatty acid / HMG CoA reductase inhibitor / insulin / GK rat / hyperphagia |
|---|
| Research Abstract |
Ghrelin increases cytosolic Ca^<2+> concentration ([Ca^<2+>]i) in NPY neurons in the hypothalamic arcuate nucleus, and leptin counteracted it, in which phosphodiesterase 3 (PDE3)-dependent leptin signaling plays a crucial role.
Transiently resistin-expressing mice using adenovirus show insulin resistance in islet β-cells via induction of SOCS-3 expression and reduction of Akt phosphorylation and impairs glucose-induced insulin secretion.
Oleic acid (OA), interacts with GPR40 in rat islet β-cells to increase [Ca^<2+>]_i via PLC-and L-type Ca^<2+> channel, potentiating insulin release. OA also stimulates glucagon release by increasing [Ca^<2+>]_i via ER Ca^<2+> release in α-cells.
Atorvastatin inhibits adipocyte maturation, SLC2A4 expression and insulin action in 3T3-L1 cells. In NSY mice, atorvastatin accelerates glucose intolerance due to insulin resistance and decreased SLC2A4 expression in WAT.
Young-adult hyperphagia in GK rats is caused by hyperactivity of ARC NPY neurons, visceral fat accumulation and leptin resistance.
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[Book] 内分泌・糖尿病科2007
Author(s)
中田正範
Total Pages
25(1), 1-7
Publisher
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Description
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[Book] 肥満研究2007
Author(s)
河野大輔
Total Pages
13(2), 215-219
Publisher
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Description
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[Book] 日本臨床増刊号2006
Author(s)
河野大輔
Total Pages
64(9), 91-97
Publisher
日本臨床社
Description
「研究成果報告書概要(和文)」より
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[Book] 肥満研究2005
Author(s)
河野大輔
Total Pages
11(1), 92-93
Publisher
日本肥満学会
Description
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[Book] 肥満研究2005
Author(s)
矢田俊彦
Total Pages
11(2), 3(117)-4(118)
Publisher
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Description
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[Book] ホルモンと臨床2004
Author(s)
河野大輔
Total Pages
52(12), 13-18
Publisher
医学の世界社
Description
「研究成果報告書概要(和文)」より
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[Book] 最新医学2004
Author(s)
前川文彦
Total Pages
59(9), 117-123
Publisher
最新医学社
Description
「研究成果報告書概要(和文)」より
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