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2006 Fiscal Year Final Research Report Summary

Biomechanics at Micro- and Nanoscale Levels

Research Project

Project/Area Number 15086101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTohoku University

Principal Investigator

WADA Hiroshi  Tohoku University, Department of Bioengineering and Robotics, Professor (30111264)

Co-Investigator(Kenkyū-buntansha) ADACHI Taiji  Kyoto University, Department of Mechanical Engineering, Associate Professor (40243323)
MASTUMOTO Takeo  Nagoya Institute of Technology, Department of Engineering Physics, Professor (30209639)
USHIDA Takashi  The University of Tokyo, Center for Disease Biology and Integrative Medicine, Professor (50323522)
TANAKA Masao  Osaka University Graduate School of Engineering Science, Division of Bioengineering, Professor (40163571)
OHASHI Toshiro  Tohoku University, Department of Bioengineering and Robotics, Associate Professor (30270812)
Project Period (FY) 2003 – 2007
KeywordsBiomechanics / Cell and Tissue / Tissue Engineering / Bioinformatics / International Exchanges of Researchers
Research Abstract

The project performed by fourteen Japanese researchers can be summarized as follows. The essential diversity of phenomena in living organisms is controlled not by genes but rather by the interaction between the micro- or nanoscale structures in cells and the genetic code, the dynamic interaction between them being especially important. Therefore, if the relationship between the dynamic environment of cells and tissues and their function can be elucidated, it is highly possible to find a method by which the structure and function of such cells and tissues can be regulated. The first goal of this research was to understand dynamic phenomena at cellular and biopolymer-organelle levels on the basis of mechanics. An attempt was then be made to apply this understanding to the development of procedures for designing and producing artificial materials and technology for producing or regenerating the structure and function of living organisms.
The Administrative Board of this project held meetings of the researchers involved in this project and released the results of the project as follows :
1. Eleven meetings of the researchers involved in this project were held.
2. Thirteen organized sessions on topics related to the project were held at the Asian Pacific Conference on Biomechanics, the Japan-Switzerland Workshop on Biomechanics, the Bioengineering Conference of the Japan Society of Mechanical Engineering, Bioengineering Division, etc.
3. A symposium open to the public was held.
4. Fifteen prominent foreign researchers were invited to make presentations and hold discussions.
5. To introduce the research of this project, five books were published : Biomechanics at Micro- and Nanoscale Levels, Introduction of the Project ; and Biomechanics at Micro- and Nanoscale Levels Volume I-IV.
6. A homepage for this project was established.

  • Research Products

    (37 results)

All 2007 2006 2005 2004 Other

All Journal Article (7 results) Presentation (22 results) Book (7 results) Remarks (1 results)

  • [Journal Article] Biomechanics at Micro- and Nanoscale levels2007

    • Author(s)
      Hiroshi Wada (ed)
    • Journal Title

      World Scientific Publishing, Singapore 4

      Pages: 180

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Medical Bio, Biomechanics at Micro- and Nanoscale and its application for medicine2007

    • Author(s)
      T. Kouno (ed. )
    • Journal Title

      Ohmsha, Japan

      Pages: 22-55

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bio Medical Engineering, 46(1), Biomechanics at Micor- and Nanoscale2007

    • Author(s)
      J. Ando (ed. )
    • Journal Title

      Japan Society of Medical and Biological Engineering

      Pages: 1-4

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale levels2007

    • Author(s)
      Hiroshi Wada (ed)
    • Journal Title

      World Scientific Publishing, Singapore 3

      Pages: 184

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale levels2006

    • Author(s)
      Hiroshi Wada (ed)
    • Journal Title

      World Scientific Publishing, Singapore 2

      Pages: 176

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale levels2005

    • Author(s)
      Hiroshi Wada (ed)
    • Journal Title

      World Scientific Publishing, Singapore 1

      Pages: 184

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale levels, Introduction of the Project2004

    • Author(s)
      Hiroshi Wada (ed)
    • Journal Title

      Sanko Printing, Japan

      Pages: 65

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 生体のマイクロ・ナノ構造と細胞のメカニクス2007

    • Author(s)
      松本健郎
    • Organizer
      公開シンポジウム「マイクロ・ナノバイオメカニクスの開拓」
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 力学刺激に対する生体マイクロ・ナノ構造の適応的応答2007

    • Author(s)
      安達泰治
    • Organizer
      公開シンポジウム「マイクロ・ナノバイオメカニクスの開拓」
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] マイクロ・ナノバイオメカニクスの再生医療への応用を目指して2007

    • Author(s)
      牛田多加志
    • Organizer
      公開シンポジウム「マイクロ・ナノバイオメカニクスの開拓」
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 生体マイクロ・ナノ構造とコンピュータモデリング2007

    • Author(s)
      田中正夫
    • Organizer
      公開シンポジウム「マイクロ・ナノバイオメカニクスの開拓」
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Structure of living organisms at micro- and nanoscale levels and cell mechanics2007

    • Author(s)
      Takeo Matsumoto
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Adaptive response by mechanical stimuli of structure of living organisms at micro- and nanoscale levels2007

    • Author(s)
      Taiji Adachi
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Application of biomechanics at micro- and nanoscale level to tissue engineering2007

    • Author(s)
      Takashi Ushida
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Computational modeling of structure of living organisms at micro- and nanoscale levels2007

    • Author(s)
      Masao Tanaka
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-10
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Structural analysis of the motor protein prestin2007

    • Author(s)
      Hiroshi Wada
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effects of cytoskeletal structures on elastic and viscoelastic properties of cells in soft tissues2007

    • Author(s)
      Takeo Matsumoto
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Biomechanical properties of collagen gel associated with microvessel formation in vitro2007

    • Author(s)
      Kazuo Tanishita
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Depth-dependent compressive behaviors of articular cartilage and chondrocytes2007

    • Author(s)
      Teruo Murakami
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Cytoskeletal reassembling and calcium signaling responses to mechanical perturbation in osteoblastic cells2007

    • Author(s)
      Taiji Adachi
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Experimental estimation of preexisting tension in single actin stress fiber of vascular cells2007

    • Author(s)
      Masaaki Sato
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Biophysical mechanisms of tension-dependent dynamic behavior of actin fibers2007

    • Author(s)
      Masahiro Sokabe
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effects of cyclic hydrostatic pressure loading on regulation of chondrocyte phenotypes2007

    • Author(s)
      Takashi Ushida
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Effects of a shear flow and water filtration on the cell layer of a hybrid vascular graft2007

    • Author(s)
      Takeshi Karino
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Tissue reconstructios for motor organs with mechanically structured grafts2007

    • Author(s)
      Kazuo Takakuda
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Microscopic analysis of bone2007

    • Author(s)
      Masao Tanaka
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Study on the mechanism of the initiation and the development of the human cerebral and cardiovascular diseases2007

    • Author(s)
      Takami Yamaguchi
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Microstructural mechanism of skeletal muscle injury and a new constitutive model of skeletal muscle2007

    • Author(s)
      Eiichi Tanaka
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Mechanical characteristics of vascular cells and tissues exposed to deformation, freezing, and shock waves : measurements and theoretical predictions2007

    • Author(s)
      Hiroshi Yamada
    • Organizer
      Symposium on Biomechanics at Micro- and Nanoscale Levels
    • Place of Presentation
      Tokyo
    • Year and Date
      2007-11-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. III2007

    • Author(s)
      Hiroshi Wada
    • Total Pages
      184
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. IV2007

    • Author(s)
      Hiroshi Wada
    • Total Pages
      180
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Medical Bio 組織・細胞の力学現象と制御2007

    • Author(s)
      幸野友浩
    • Total Pages
      22-55
    • Publisher
      (株)オーム社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 生体医工学, 46(1)解説特集 : マイクロ・ナノバイオメカニクス2007

    • Author(s)
      安藤譲二
    • Total Pages
      1-4
    • Publisher
      (社)日本生体医工学会
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. II2006

    • Author(s)
      Hiroshi Wada
    • Total Pages
      176
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. I2005

    • Author(s)
      Hiroshi Wada
    • Total Pages
      184
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Introduction of the Project2004

    • Author(s)
      Hiroshi Wada
    • Total Pages
      65
    • Publisher
      Sanko Printing
    • Description
      「研究成果報告書概要(和文)」より
  • [Remarks]

    • URL

      http://www.wadalab.mech.tohoku.ac.jp/nano-biomech/index.html

URL: 

Published: 2010-06-09  

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