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2006 Fiscal Year Final Research Report Summary

Mechanically Engineered Devices with Micro- and Nano Structures for Reconstructions of Locomotory Organs

Research Project

Project/Area Number 15086206
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Science and Engineering
Research InstitutionTokyo Medical and Dental University

Principal Investigator

TAKAKUDA Kazuo  Tokyo Medical and Dental University, Institute of Biomaterials and Bioengineering, Professor (70108223)

Co-Investigator(Kenkyū-buntansha) MUNETA Takeshi  Tokyo Medical and Dental University, Graduate School, Professor (50190864)
ITO Soichiro  Tokyo Medical and Dental University, Human Gene Science Center, Associate Professor (10242190)
IMAI Yoji  Tokyo Medical and Dental University, Professor Emeritus (50013975)
HORIE Mikio  Tokyo Institute of Technology, 精密工学研究所, Professor (00126327)
Project Period (FY) 2003 – 2006
KeywordsBiomechanics / Biomaterials / Mechanical Stimuli / Tissue Engineering / Locomotory Orgrans / Microstructure
Research Abstract

1. Biological attachment of percutaneous devices and dental implants
For the improved performance of percutaneous devices and dental implants, a model specimen was prepared which had the microstructure on the specimen surfaces to which collagen fibers of surrounding tissues anchors spontaneously. Implantation tests using the rats demonstrated that all of the specimens without the microstructure dropped out from the skin, however, significantly less number of specimens with the microstructure were dropped out of skin. Further, histological observation demonstrated the anchoring of collagen fibers to the microsurtucture
2. Biological fixation of the artificial ligaments to bone tunnels
For the improved anchorage of the artificial ligaments to bone tunnels, nonwoven polyester fabrics specimens with sparse fiber structure were prepared, in which bone ingrowth into the space between the fibers was expected. Implantation of the specimen into the femur of rat demonstrated significant greater anchorage and bone ingrowth in the chitin coated specimens than noncoated specimens. Thus efficacy of chitin coating was proved.
3. Regeneration of small diameter arteries with mechanical biocompatibility
Accelularized bioscaffolds which have the similar mechanical compliances with natural arteries were prepared. The scaffolds were implanted to the common carotid artery of rat. After 4 weeks implantation, the scaffolds were found patent and inner lumen was covered by the endothelial cells. Thus we suggested the possibility of reconstruct small diameter arteries with the bioscaffolds having the mechanical biocompatibility as well as material biocompatibility.
4. Regeneration of peripheral nerve
The devices combining biological materials and bioabsorbable synthetic polymers were developed for the regeneration of peripheral nerves. The structure to realize the enough strength of devices to maintain the inner cavity was found crucial for the regeneration.

  • Research Products

    (33 results)

All 2007 2006 2005 2004 2003

All Journal Article (15 results) (of which Peer Reviewed: 7 results) Presentation (13 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Bone-demineralized bone-bone grafts for ligament reconstruction.2007

    • Author(s)
      T. Yamada
    • Journal Title

      Journal of Biomechanical Science and Engineering 2

      Pages: 23-33

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Reconstruction of bone fenestration on mandiblar by the guided bone regeneration methods with b-TCP/PLGC membranes.2007

    • Author(s)
      Y. Koyama
    • Journal Title

      Journal of Nanoscience and Nanotechnology 7

      Pages: 859-861

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Material design of bioabsorbable inorganic/organic composites for bone regeneration.2007

    • Author(s)
      K. Takakuda
    • Journal Title

      Journal of Nanoscience and Nanotechnology 7

      Pages: 738-741

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Regeneration of peripheral nerves by bioabsorbable polymer tubes with fibrin gel.2007

    • Author(s)
      K. Nakayama
    • Journal Title

      Journal of Nanoscience and Nanotechnology 7

      Pages: 730-733

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Enhancement of peripheral nerve regeneration by using bioabsorbable polymer tubes packed with fibrin gel.2007

    • Author(s)
      K. Nakayama
    • Journal Title

      Artificial Organs 31

      Pages: 500-508

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Bone-demineralized bone-bone grafts for ligament reconstruction.2007

    • Author(s)
      T.Yamada
    • Journal Title

      Journal of Biomechanical Science and Engineering 2

      Pages: 23-33

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2007

    • Author(s)
      Hiroshi Wada
    • Journal Title

      World Scientific, Singapore Volume IV

      Pages: 107-116

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of bioabsorbable DURA MATER2006

    • Author(s)
      K. Takakuda
    • Journal Title

      Advances in Science and Technology 49

      Pages: 165-167

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Bone regeneration with β-TCP/PLGC membranes.2006

    • Journal Title

      Advances in Science and Technology 49

      Pages: 258-262

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Bone regeneration with β-TCP/PLGC membranes.2006

    • Author(s)
      Y. Koyama
    • Journal Title

      Advances in Science and Technology 49

      Pages: 258-262

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2006

    • Author(s)
      Hiroshi Wada
    • Journal Title

      World Scientific, Singapore Volume II

      Pages: 108-118

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bone repair analysis in a novel biodegradable hydroxyapatite/collagen composite implanted in bone.2005

    • Author(s)
      T. Nishikawa
    • Journal Title

      Implant Dentistry 214

      Pages: 252-260

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Biomechanics at Micro- and Nanoscale Levels2005

    • Author(s)
      Hiroshi Wada
    • Journal Title

      World Scientific, Singapore Volume I

      Pages: 113-122

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of cyclic tensile forces on the strength of fibrous tissue examined in an in vivo model.2004

    • Author(s)
      K. Takakuda
    • Journal Title

      JSME International Journal, Series C 47

      Pages: 1056-1061

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Bone regeneration with organic/inorganic composite materials.2004

    • Author(s)
      K. Takakuda
    • Journal Title

      Transactions of Materials Research Society of Japan 29

      Pages: 2943-2949

    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Bone Regeneration with β-TCP/PLGC membranes2006

    • Author(s)
      Koyama Y
    • Organizer
      CIMTEC 2006
    • Place of Presentation
      Sicily
    • Year and Date
      2006-06-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Development of Bioabsorbable DURA MATER2006

    • Author(s)
      Takakuda K
    • Organizer
      CIMTEC 2006
    • Place of Presentation
      Sicily
    • Year and Date
      2006-06-05
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regeneration of Dura Mater with Bioabsorbable Membranes2005

    • Author(s)
      Takakuda K
    • Organizer
      2nd Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Taipei
    • Year and Date
      2005-11-25
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Bone Regeneration with Organic/Inorganic Composite Materials2005

    • Author(s)
      Koyama Y
    • Organizer
      2005 Sino-Japanese Conference on Stomatology
    • Place of Presentation
      Shanghai
    • Year and Date
      2005-11-12
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regeneration of peripheral nerves with bioabsorbable tubes2005

    • Author(s)
      Nakayama K
    • Organizer
      2nd Japan-Switzerland Workshop on Biomechanics
    • Place of Presentation
      Kyoto
    • Year and Date
      2005-09-14
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Treatment of Bone Fenestration on Mandibular by the GBR Method with b-TCP/PLGC Membranes2005

    • Author(s)
      Koyama Y
    • Organizer
      International Symposium on Soft-Nanotechnology 2005
    • Place of Presentation
      Sapporo
    • Year and Date
      2005-06-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Bone Regeneration with Hydroxyapatite/Collagen Sponges2005

    • Author(s)
      Koyama Y
    • Organizer
      International Symposium on Soft-Nanotechnology 2005
    • Place of Presentation
      Sapporo
    • Year and Date
      2005-06-21
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Bone Regeneration with Bioabsorbable Composite Materials2005

    • Author(s)
      Takakuda K
    • Organizer
      International Symposium on Soft-Nanotechnology 2005
    • Place of Presentation
      Sapporo
    • Year and Date
      2005-06-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Regeneration of Peripheral Nerves by Bioabsorbable Polymer Tubes with Fibrin Gel2005

    • Author(s)
      Nakayama K
    • Organizer
      International Symposium on Soft-Nanotechnology 2005
    • Place of Presentation
      Sapporo
    • Year and Date
      2005-06-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Fixation of fibrous tissues to artificial implants with micro-structured surface2005

    • Author(s)
      Takakuda K
    • Organizer
      International Symposium on Soft-Nanotechnology 2005
    • Place of Presentation
      Sapporo
    • Year and Date
      2005-06-20
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Development of Bioabsorbable Dural Substitute2004

    • Author(s)
      Takakuda K
    • Organizer
      4th Asian Int Symp Biomaterials
    • Place of Presentation
      Tsukuba
    • Year and Date
      2004-11-17
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Strength and Structure of Fibrous Tissues under Mechanical Stimuli2004

    • Author(s)
      Takakuda K
    • Organizer
      First Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Osaka
    • Year and Date
      2004-03-26
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Bone Regeneration with Organic/Inorganic Composite Materials2003

    • Author(s)
      Takakuda K
    • Organizer
      The 8th IUMRS International Conference on Advanced Materials
    • Place of Presentation
      Yokohama
    • Year and Date
      2003-10-09
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. IV2007

    • Author(s)
      Hiroshi Wada
    • Total Pages
      107-116
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. II2006

    • Author(s)
      Hiroshi Wada
    • Total Pages
      108-118
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] Biomechanics at Micro- and Nanoscale levels, Vol. I2005

    • Author(s)
      Hiroshi Wada
    • Total Pages
      113-122
    • Publisher
      World Scientific Publishing
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 軟組織再生のための吸収性多孔質材料2006

    • Inventor(s)
      高久田和夫
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      特願2006-276391号
    • Filing Date
      2006-10-10
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 神経再生チューブ2005

    • Inventor(s)
      高久田和夫
    • Industrial Property Rights Holder
      東京医科歯科大学
    • Industrial Property Number
      特願2005-156044号
    • Filing Date
      2005-05-27
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-06-09  

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