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2004 Fiscal Year Annual Research Report

移植腎へのHGF遺伝子導入の臨床研究

Research Project

Project/Area Number 15109009
Research InstitutionOsaka University

Principal Investigator

奥山 明彦  大阪大学, 医学系研究科, 教授 (20093388)

Co-Investigator(Kenkyū-buntansha) 高原 史郎  大阪大学, 医学系研究科, 寄附講座教授 (70179547)
今井 圓裕  大阪大学, 医学系研究科, 講師 (00223305)
KeywordsHepatocyte Growth Factor / 遺伝子治療 / electropotation法 / 腎移植 / 慢性拒絶反応 / 線維化 / 大動物 / 長期生着
Research Abstract

研究実績の概要
(1)ブタ腎へのelectroporatign法によるHGF遺伝子直接導入(安全性試験):平成15年度報告に記載した安全性試験の結果を論文投稿し、追加実験(病理診断とPCR法による長期遺伝子発現の有無の確認)を要求され、実施した。再投稿し受理された(Gene Therapy : in press)
(2)ブタ腎へのHGF直接投与による有効性および安全性試験:大阪大学医学部附属病院・遺伝子治療臨床研究審査委員会から要求された追加実験有効性試験は終了。

  • Research Products

    (8 results)

All 2004 Other

All Journal Article (8 results)

  • [Journal Article] Comprehensive examination of gene expression associated with long-term stable graft acceptance2004

    • Author(s)
      H.Zhang
    • Journal Title

      Clin Transplant 18

      Pages: 70-78

  • [Journal Article] Direct HGF gene transfer into kidney suppressed cyclosporine A nephropathy.2004

    • Author(s)
      Yazawa Y
    • Journal Title

      Nephrol Dial Transplant 19

      Pages: 1-5

  • [Journal Article] Electroporation-mediated HGF gene transfer ameliorated cyclosporine nephrotoxicity.2004

    • Author(s)
      Mizui M
    • Journal Title

      Kidney Int 65

      Pages: 2041-2053

  • [Journal Article] Activation of the signal transducer and activator of transcription signaling pathway in renal proximal tubular cells by albumin.2004

    • Author(s)
      Nakajima H
    • Journal Title

      J Am Soc Nephrol 15

      Pages: 276-285

  • [Journal Article] Exploring RNA Interference as a Therapeutic Strategy for Renal Disease.

    • Author(s)
      Takabatake Y
    • Journal Title

      Gene Therapy in press

  • [Journal Article] Actions of a Rho Signaling Inhibitor, Y-27632, Against Progression in a Mouse Model of Hepatocellular Carcinoma

    • Author(s)
      F.Xue
    • Journal Title

      Gastroenterology in press

  • [Journal Article] Rapid recovery from liver injury in hepatectomized rat by naked HGF gene transfer

    • Author(s)
      Kobayashi, S
    • Journal Title

      Hepatology in press

  • [Journal Article] Electroporation-mediated HGF gene transfection protected the kidney against graft injury.

    • Author(s)
      Isaka, Y
    • Journal Title

      Gene Therapy in press

URL: 

Published: 2006-07-12   Modified: 2016-04-21  

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