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2006 Fiscal Year Final Research Report Summary

Development of mutant mice carrying base-substitutions in target genes.

Research Project

Project/Area Number 15200032
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionRIKEN

Principal Investigator

GONDO Yoichi  RIKEN, Population and Quantitative Genomics Team, Deputy Project Director, 個体遺伝情報研究チーム, プロジェクト副ディレクター (40225678)

Co-Investigator(Kenkyū-buntansha) AIBA Atsu  Kobe University, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (20271116)
UENO Naoto  National Institute of Natural Sciences National Institute for Basic Biology, Division of Morphogenesis., Professor, 基礎生物学研究所・形態形成研究部門, 教授 (40221105)
KOSEKI Haruhiko  Niigata University, Graduate School of Medical and Dental Sciences, Professor, 免疫器官形成研究グループ, グループデイレクター (40225446)
KOMINAMI Ryo  Laboratory for Cytokine Signaling, Senior Research Scientist, 大学院医歯学総合研究科, 教授 (40133615)
NISHIDA Keigo  RIKEN, サイトカイン制御研究グループ, 上級研究員 (80360618)
Project Period (FY) 2003 – 2006
Keywordsmutagenesis / mouse / reverse genetics / genome function / gene function / induced mutation / ethyl nitrosourea
Research Abstract

Frozen sperm archive was constructed encompassing 10,000 mice carrying a total of 30,000,000 ENU-induced base substitutions. The genomic DNA archive was also constructed. The objective of this collaborative research is to establish a system by which any researchers may freely and easily obtain mouse strains that carry single-base substitutions in target genes from the large-scale frozen sperm archive. In the 4 years term, members of this research group designed the PCR primers for their target genes and Gondo successfully discovered mutant lines carrying ENU-induced mutations in their target genes. Based upon the progress in this research group, we have made the system available to any researchers within as well as outside of Japan. By the end of the 4 years term, 43 researchers including the members of this research requested a total of 251 target genes, the number of which is 5-fold more than that of the beginning. The number of discovered mutations had already exceeded 400. By using the in vitro fertilizing method, Gondo revived more than 70 mutant lines as live mice. Thus, we have provided expected mutant lines to the users including all the members of this research who designed the PCR primers. It vindicated that not only the system was well established but also we achieved much more than we originally expected. At present, we and users are conducting the analysis of gene functions by using the mutant mouse lines. Some of them have already been published : e.g., model mice for schizophrenia, depression and polydactyly. Summarizing the discovered mutation spectra. 61%, 10% and 29% of the mutations in coding sequences were missesnse, nonsense or splicing anomaly, and synonymous mutatons, respectively. Considering that 1% of mouse genome is coding sequences, the frozen sperm archive consists of 180,000 missense and 30,000 nonsense or splicing anomaly mutations.

  • Research Products

    (69 results)

All 2007 2006 2005 2004 2003

All Journal Article (64 results) Book (5 results)

  • [Journal Article] Behavioral phenotypes of Discl messense mutations in mice.2007

    • Author(s)
      S.J.Clapcote
    • Journal Title

      Neuron 54

      Pages: 383-402

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud.2007

    • Author(s)
      H.Masuya
    • Journal Title

      Genomics 89(2)

      Pages: 207-214

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum2007

    • Author(s)
      H.Nakao
    • Journal Title

      Neurosci. Res 57

      Pages: 538-543

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Transposon-tagged mutagenesis in the rat2007

    • Author(s)
      K.Kitada
    • Journal Title

      Nature Methods 4(2)

      Pages: 131-133

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Mammalian Polycomb Scmhl mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes.2007

    • Author(s)
      Y.Takada
    • Journal Title

      Development 134(3)

      Pages: 579-590

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling2007

    • Author(s)
      R.Haraguchi
    • Journal Title

      Development 134

      Pages: 525-533

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Behavioral phenotype of Disc1 messense mutations in mice.2007

    • Author(s)
      S.J.Clapcote, Lipina, T.V.Millar, J.K..Mackie, S.Christie, S.Ogawa, F.Lerch, J.P., Trimble, K..Uchiyama, M., Sakuraba, Y.Kaneda, H.Shiroishi, T.Houslay, M.D.Henkelman, R.M.Sled, J.G.Gondo, Y.Porteous, D.J., Roder, J.C.
    • Journal Title

      Neuron 54

      Pages: 383-402

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A series of ENU-induced single-base substitutions in a long-range cis-element altering Sonic hedgehog expression in the developing mouse limb bud.2007

    • Author(s)
      H.Masuya, Sezutsu, H., Sakuraba, Y., Sagai, T., Hosoya, M., Kaneda, H., Miura, I, Wakana, S., Gondo, Y., Shiroishi, T., Kobayashi, K, Sumiyama, K., Shimizu, A., Nagano, J., Yokoyama, H., Kaneko, S., Sakurai, N., Okagaki, Y., Noda, T., Wakana, S., Gondo, Y., Shiroishi, T.
    • Journal Title

      Genomics 89.2

      Pages: 207-214

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mutant Mouse : bona fide biosimulator for the functional annotation of gene and genome networks.2007

    • Author(s)
      Y.Gondo
    • Journal Title

      In Springer IIMMS Series "Immunoinformatics" Chapter 10 (Eds by C. Schonbach, S. Ranganathan, V. Brusic)( Springer, New York) (in press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum2007

    • Author(s)
      H.Nakao, Nakao, K, Kano, M., Aiba, A
    • Journal Title

      Neurosci. Res. 57

      Pages: 538-543

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Transposon-tagged mutagenesis in the rat.2007

    • Author(s)
      K.Kitada, Ishishita, S, Tosaka, K, Takahashi, R., Ueda, M., Keng, V.W., Horie, K., Takeda, J.
    • Journal Title

      Nat. Methods 4.2

      Pages: 131-133

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Zinc is required for FceRI-mediated mast cell activation.2007

    • Author(s)
      K.Kabu, Yamasaki, S., Kamimura, D., Ito, Y., Hasegawa, A., Sato, E., Kitamura, H., Nishida, K., Hirano.T.
    • Journal Title

      J. Immunol. 177

      Pages: 1296-1305

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes2007

    • Author(s)
      Y.Takada, Isono, K., Shinga, J., Turner, J.M.A, Kitamura, H., Ohara, 0., Watanabe, G, Singh, P.B, Kamijo, T., Jenuwein, T., Burgoyne, P.S, Koseki, H
    • Journal Title

      Development 134.3

      Pages: 579-590

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling.2007

    • Author(s)
      R.Haraguchi, Motoyama, J., Sasaki, H., Satoh, Y., Miyagawa, S., Nakagata, N., Moon, A., Yamada, G
    • Journal Title

      Development 134

      Pages: 525-533

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 変異マウスライブラリー : ENUランダムミュータジェネシスで標的遺伝子に点突然変異をもつマウスを構築する.2006

    • Author(s)
      権藤洋一
    • Journal Title

      生物の科学 遺伝 別冊 21

      Pages: 113-118

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Control of developmental regulators by Polycomb in human embryonic stem cells.2006

    • Author(s)
      T.I.Lee
    • Journal Title

      Cell 125

      Pages: 301-313

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] WTC deafness Kyoto (dfk) : a rat model for extensive investigations of Kcnq1 functions.2006

    • Author(s)
      H.Gohma
    • Journal Title

      Physiol. Genomics 24(3)

      Pages: 198-206

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expression of TCRab partly rescues developmental arrest and apoptosis of abT cells in Bcl11b-/- mice2006

    • Author(s)
      J.Inoue
    • Journal Title

      J. Immunol. 176

      Pages: 5871-5879

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Zinc is required for FceRI-mediated mast cell activation2006

    • Author(s)
      K.Kabu
    • Journal Title

      J. Immunol. 177

      Pages: 1296-1305

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Distinct roles of Polycomb group gene products between transcriptionally repressed and active domains of Hoxb82006

    • Author(s)
      Y.Fujimura
    • Journal Title

      Development 133(12)

      Pages: 2371-2381

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase2006

    • Author(s)
      K.Kumada
    • Journal Title

      J. Cell Biol. 172(6)

      Pages: 835-836

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Altered emotional behavioral responses in mice lacking brain-type fatty acid binding protein gene.2006

    • Author(s)
      Y.Owada
    • Journal Title

      European J. Neuroscience 24

      Pages: 175-187

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation.2006

    • Author(s)
      J.Hyodo-Miura
    • Journal Title

      Dev. Cell 11

      Pages: 69-79

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Mutant mouse library : Construction of mice carrying point mutations in target genes by ENU random mutagenesis (in Japanese)2006

    • Author(s)
      Y.Gondo
    • Journal Title

      Seibutsu no Kagaku IDEN 21(suppl.)

      Pages: 113-118

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Control of developmental regulators by Polycomb in human embryonic stem cells2006

    • Author(s)
      T.I.Lee, Jenner, R.G., Boyer, L.A., Guenther, M.G., Levine, S.S., Kumar, R.M., Chevalier, B., Johnstone, S.E., Cole, M.F., Isono, K, Koseki, H., Fuchikami, T., Abe, K., Murray, H.L, Zucker, J.P., Yuan, B., Bell, G.W., Herbolsheimer, E., Hannett, N.M., Sun, K., Odom, D.T., Otte, A.P., Volkert, T.L, Bartel, D.P., Melton, D.A., Gifford, D.K., Jaenisch, R., Young, R.A.
    • Journal Title

      Cell 125

      Pages: 301-313

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gene-driven method as a reverse genetics analysis. (in Japanese)2006

    • Author(s)
      Y.Gondo
    • Journal Title

      Saibo Kogaku, Suppl. Experimental Protocol Series "Mouse phenotype analysis protocol : from morphology to physiology, Chap 10 (Shujun-sha)

      Pages: 214-222

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] WTC deafness Kyoto (dfk) : a rat model for extensive investigations of Kcnq1 functions.2006

    • Author(s)
      H.Gohma, Kuramoto, T., Kuwamura, M., Okajima, R., Tanimoto, N., Yamasaki, K, Nakanishi, S., Kitada, K., Makiyama, T., Akao, M., Kita, T., Sasa, M., Serikawa, T.
    • Journal Title

      Physiol. Genomics. 24.3

      Pages: 198-206

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expression of TCRab partly rescues developmental arrest and apoptosis of abT cells in Bcl11b-/-micel.2006

    • Author(s)
      J.Inoue, Kanefuji, T., Okazuka, K, Watanabe, H., Mishima Y., Kominami.R.
    • Journal Title

      J. Immunology 176

      Pages: 5871-5879

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Distinct roles of Polycomb group gene products between transcriptionally repressed and active domains of Hoxb8.2006

    • Author(s)
      Y.Fujimura, Isono, K, Vidal, M., Endoh, M., Kajita, H., Mizutani-Koseki, Y., Takihara, Y., van Lohuizen, M., Otte, A., Jenuwein, T., Deschamps, J., Koseki, H.
    • Journal Title

      Development 133.12

      Pages: 2371-2381

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The selective continued linkage of centromeres from mitosis to interphase in the absence of mammalian separase2006

    • Author(s)
      K.Kumada, Yao, R., Kawaguchi, T., Karasawa, M., Hoshikawa, Y., Ichikawa, K., Sugitani, Y., Imoto, I., Inazawa, J., Sugawara, M., Yanagida, M., Noda, T.
    • Journal Title

      J. Cell Biol. 172.6

      Pages: 835-846

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Altered emotional behavioral responses in mice lacking brain-type fatty acid binding protein gene.2006

    • Author(s)
      Y.Owada, Abdelwahab, S.A., Kitanaka, N., Sakagami, H., Takano, H., Sugitani, Y., Sugawara, M., Kawashima, H., Kiso, Y., Mobarakeh, J.I., Yanai, K, Kaneko, K, Sasaki, H., Kato, H., Saino-Saito, S., Matsumoto, N., Akaike, N., Noda, T., Kondo, H.
    • Journal Title

      European J. Neuroscience 24

      Pages: 175-187

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] XGAP, an ArfGAP, is required for polarized localization of PAR proteins and cell polarity in Xenopus gastrulation.2006

    • Author(s)
      J.Hyodo-Miura, Yamamoto, T.S., Hyodo, A.C., Iemura, S., Kusakabe, M., Nishida, E., Natsume, T., Ueno, N.
    • Journal Title

      Dev. Cell. 11

      Pages: 69-79

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Molecular characterization of ENU mouse mutagenesis and archives.2005

    • Author(s)
      Y.Sakuraba
    • Journal Title

      Biochem. Biophys. Res. Commun. 336

      Pages: 609-616

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Implementation of the modified-SHIRPA protocol for screening of dominant phenotypes in a large-scale ENU mutagenesis program.2005

    • Author(s)
      H.Masuya
    • Journal Title

      Mammalian Genome 16

      Pages: 829-837

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Farnesylation of retinal transducin underlies its translocation during light adaptation.2005

    • Author(s)
      H.Kassai
    • Journal Title

      Neuron 47

      Pages: 529-539

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] p53 prevents maturation of T cell development to the immature CD4-CD8+ stage in Bcl11b-/- mice2005

    • Author(s)
      K.Okazuka
    • Journal Title

      Biochem. Biophys. Res. Commun 328

      Pages: 545-549

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Fc RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane2005

    • Author(s)
      K.Nishida
    • Journal Title

      J. Cell Biol. 170

      Pages: 115-126

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hepatocyte, Growth Factor Activator Inhibitor Type 1 (HAI-1) is Required for Branching Morphogenesis in the Chorioallantonic Placenta2005

    • Author(s)
      H.Tanaka
    • Journal Title

      Mol. Cell. Biol. 25

      Pages: 5687-5698

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular characterization of ENU mouse mutagenesis and archives.2005

    • Author(s)
      Y.Sakuraba, Sezutsu, H., Takahasi, K.R., Tsuchihashi, K., Ichikawa, R., Fujimoto, N., Kaneko, S., Nakai, Y., Uchiyama, M., Goda, N., Motoi, R., Ikeda, A, Karashima, Y., Inoue, M., Kaneda, H., Masuya, H., Minowa, O., Noguchi, H., Toyoda, A., Sakaki, Y., Wakana, S., Noda, T., Shiroishi, T., Gondo, Y.
    • Journal Title

      Biochem. Biophys. Res. Commun. 336

      Pages: 609-616

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Implementation of the modified-SHIRPA protocol for screening of dominant phenotypes in a large-scale ENU mutagenesis program.2005

    • Author(s)
      H.Masuya, Inoue, M., Wada, Y., Shimizu, A., Nagano, J, Kawai, A., Inoue, A, Kagami, T., Hirayama, T., Yamaga, A., Kaneda, H., Kobayashi, K., Minowa, 0., Miura, I., Gondo, Y., Noda, T., Wakana, S., Shiroishi, T.
    • Journal Title

      Mammalian Genome 16

      Pages: 829-837

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] p53 prevents maturation of T cell development to the immature CD4-CD8+ stage in Bcl1lb-/-mice.2005

    • Author(s)
      K.Okazuka, Wakabayashi, Y., Kashihara, M., Inoue, J., Sato, T., Yokoyama, M., Aizawa, S., Aizawa, Y., MishimaY., Kominami, R.
    • Journal Title

      Biochem. Biophys. Res. Commun. 328

      Pages: 545-549

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Fc RI-mediated mast cell degranulation requires calcium-independent microtubule-dependent translocation of granules to the plasma membrane.2005

    • Author(s)
      K.Nishida, Yamasaki, S., Ito, Y., Kabu, K., Hattori, K., Tezuka, T., Nishizumi, H., Kitamura, D., Goitsuka, R., Geha, R.S., Yamamoto, T., Yagi, T., Hirano.T.
    • Journal Title

      J. Cell Biol. 170

      Pages: 115-126

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hepatocyte Growth Factor Activator Inhibitor Type 1 (HAI-1) is Required for Branching Morphogenesis in the Chorioallantonic Placenta.2005

    • Author(s)
      H.Tanaka, Nagaike.K., Takeda, N., Itoh, H., Kohama, K., Fukushima, T., Miyata, S., Uchiyama, S., Uchinokura, S., Shimomura, T., Miyazawa, K., Kitamura, N., Yamada, G, Kataoka, H.
    • Journal Title

      Mol. Cell. Biol. 25

      Pages: 5687-5698

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog (Shh)2004

    • Author(s)
      T.Sagai
    • Journal Title

      Mammalian Genome 25

      Pages: 23-34

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.2004

    • Author(s)
      M.Inoue
    • Journal Title

      Human Molecular Genetics 13

      Pages: 1147-1157

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Develpoment and implementation of a database system to manage a large-scale mouse ENU-mutagenesis program.2004

    • Author(s)
      H.Masuya
    • Journal Title

      Mammalian Genome 15

      Pages: 404-411

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Enamelin(Enam) is essential for amelogenesis : ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta(AI).2004

    • Author(s)
      H.Masuya
    • Journal Title

      Human Molecular Genetics 14

      Pages: 575-583

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] ENUマウスミュータジェネシスと新しい逆向遺伝学.2004

    • Author(s)
      櫻庭喜行
    • Journal Title

      蛋白質核酸酵素 増刊 49(17)

      Pages: 2642-2648

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequence-SNP analysis2004

    • Author(s)
      K.Abe
    • Journal Title

      Genome Research 14

      Pages: 2439-2447

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Phylogenetic conservation of a limb-specific, cis-acting regulator of Sonic hedgehog (Shh)2004

    • Author(s)
      T.Sagai, Masuya, H., Tamura, M., Shimizu, K., Yada, Y., Wakana, S., Gondo Y., Noda, T., Shiroishi, T.
    • Journal Title

      Mammalian Genome 15

      Pages: 23-34

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.2004

    • Author(s)
      M.Inoue, Sakuraba, Y., Motegi, H., Kubota, N., Toki, H., Matsui, J., Toyoda, Y., Miwa, I., Terauchi, Y., Kadowaki, T., Shigeyama, Y., Kasuga, M., Adachi, T., Fujimoto, N., Matsumoto, R., Tsuchihashi, K., Kagami, T., Inoue, A., Kaneda, H., Ishijima, J., Masuya, H., Suzuki, T., Wakana, S., Gondo, Y., Minowa, 0., Shiroishi, T., Noda, T.
    • Journal Title

      Human Molecular Genetics 13

      Pages: 1147-1157

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development and implementation of a database system to manage a large-scale mouse ENU-mutagenesis program.2004

    • Author(s)
      H.Masuya, Nakai, Y., Motegi, H., Niinaya, N., Kida, Y., Kaneko, Y., Aritake, H., Suzuki, N., Ishijima, J., Koorikawa, K., Suzuki, T., Aritake, H., Suzuki, N., Ishijima, J., Koorikawa, K., Suzuki, T.Takahashi, K.R., Minowa, 0., Noda, T., Wakana, S., Gondo Y., Shiroishi T.
    • Journal Title

      Mammalian Genome 15

      Pages: 404-411

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Enamelin (Enam) is essential for amelogenesis : ENU-induced mouse mutants as models for different clinical subtypes of human amelogenesis imperfecta (AI)2004

    • Author(s)
      H.Masuya, Shimizu, K., Sezutsu, H., Sakuraba, Y., Nagano, J., Shimizu, A., Fujimoto, N., Kawai, A., Miura, I., Kaneda, H., Kobayashi, K, Ishijima, J., Maeda, T., Gondo, Y, Noda, T., Wakana S., Shiroishi T.
    • Journal Title

      Human Molecular Genetics 14

      Pages: 575-583

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ENU mouse mutagenesis and advanced reverse genetics. (in Japanese)2004

    • Author(s)
      Y.Sakuraba, Gondo, Y.
    • Journal Title

      Tanpakushitsu Kakusan Koso 49(17 Suppl)

      Pages: 2642-2648

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Contribution of Asian mouse subspecies Mus musculus molossinus to genomic constitution of strain C57BL/6J, as defined by BAC-end sequence-SNP analysis2004

    • Author(s)
      K.Abe, Noguchi, H., Tagawa, K., Yuzuriha, M., Toyoda, A., Kojima, T., Ezawa, K., Saitou, N., Hattori, M., Sakaki, Y., Moriwaki, K., Shiroishi, T.
    • Journal Title

      Genome Research 14

      Pages: 2439-2447

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Large-scale mouse mutagenesis project. (in Japanese)2004

    • Author(s)
      Y.Gondo
    • Journal Title

      New Advancement for Genomics and Proteomics, N.T.S.

      Pages: 1062-1070

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Induced mutations. (in Japanese)2004

    • Author(s)
      M.Inoue, Gondo, Y.
    • Journal Title

      Development and Maintenance of Model Animals. L.I.C.

      Pages: 120-128

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Megasatellite DNA.2003

    • Author(s)
      Y.Gondo
    • Journal Title

      Nature Encyclopedia of the Human Genome 3

      Pages: 862-865

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Bcl11b is required for differentiation and survival of αβ T lymphocytes.2003

    • Author(s)
      Y.Wakabayashi
    • Journal Title

      Nature Immunology 4

      Pages: 533-539

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] PKCd is essential for Dishevelled function in a non-canonical Wnt pathway that regulates Xenopus convergent extension movements2003

    • Author(s)
      N.Kinoshita
    • Journal Title

      Genes. Dev. 17

      Pages: 1663-1676

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Megasatellite DNA.2003

    • Author(s)
      Y.Gondo, Ikeda, J.-E
    • Journal Title

      NATURE Encyclopedia of the Human Genome 3

      Pages: 862-865

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Bcl11b is required for differentiation and survival of αβ T lymphocytes2003

    • Author(s)
      Y.Wakabayashi, Watanabe, H., Inoue, J., Takeda, N., Sakata, J., Mishima, Y., Hitomi, J., Yamamoto, T., Utsuyama, M., Niwa, O., Aizawa, S., Kominami, R.
    • Journal Title

      Nature immunology 4

      Pages: 533-539

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] PKCd is essential for Dishevelled function in a non-canonical Wnt pathway that regulates Xenopus convergent extension movements.2003

    • Author(s)
      N.Kinoshita, Iioka, H., Miyakoshi, A., Ueno, N.
    • Journal Title

      Genes Dev. 17

      Pages: 1663-1676

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Analysis of genome function by mutagenesis (in Japanese)2003

    • Author(s)
      Y.Gondo
    • Journal Title

      Genomic Medicine, Kagaku-Dojin

      Pages: 51-61

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] IIMMS Series "Immunoinformatics", : Mutant Mouse : bona fide biosimulator for the functional annotation of gene and genome networks.(Eds by C. Schonbach, S. Ranganathan, V. Brusic)(Springer)2007

    • Author(s)
      Y.Gondo
    • Publisher
      Springer(in press)
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 細胞工学別冊実験プロトコルシリーズ マウス表現型解析プロトコール : 形態分析から生理機能解析まで 第10章 逆遺伝学的解析法,逆遺伝学的解析法としてのGene-driven法.2006

    • Author(s)
      権藤洋一
    • Total Pages
      9
    • Publisher
      秀潤社
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] ゲノミクス・プロテオミクスの新展開 生物情報の解析と応用 : 大規模マウスミュータジェネシスプロジェクト.2004

    • Author(s)
      権藤洋一
    • Total Pages
      9
    • Publisher
      (株)エヌ・ティー・エス
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] モデル動物の作製と維持 第4節 誘発変異.2004

    • Author(s)
      井上麻紀
    • Total Pages
      9
    • Publisher
      (株)エル・アイ・シー
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] ゲノム創薬 ミュータジェネシスによるゲノム機能解析.2003

    • Author(s)
      権藤洋一
    • Total Pages
      11
    • Publisher
      化学同人
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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