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2005 Fiscal Year Final Research Report Summary

High-performance Stent Technology

Research Project

Project/Area Number 15200038
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

MATSUDA Takehisa  KYUSHU UNIVERSITY, Graduate School of Medicine, Professor, 大学院・医学研究院, 教授 (60142189)

Co-Investigator(Kenkyū-buntansha) KIDOAKI Satoru  KYUSHU UNIVERSITY, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (10336018)
SHIMOKAWA Hiroaki  KYUSHU UNIVERSITY, Graduate School of Medicine, Associate Professor, 大学院・医学研究院, 助教授 (00235681)
Project Period (FY) 2003 – 2005
Keywordsstent / scaffold / endothelial cell
Research Abstract

This study aimed at developing high biocompatible stent technology based on ex vivo cell seeding by combination of cell engineering, matrix engineering and scaffold engineering, by which rapid complete endothelialization on an implanted stent as to fully prevent thrombus formation, thus avoiding stenosis and occlusion, will be achieved. To this end, the authors developed endothelial cell and endothelial progenitor cell, both of which are harvested from autologous tissue or blood, are seeded and cultured to form monolayered tissue on the whole body of stent. As for matrix engineering, vinylated biomolecules include albumin, gelatin and heparin were photopolymerized under visible light-irradiation to form completely cover the stent surface prior to cell seeding. As for scaffold engineering, the authors devised electrospinning method using synthetic biodegradable elastomer (copolymer of lactide and caprolactone) to form a mesh-type cover stent. Bioactive substances such as collagen, heparin and growth factor were also co-electronspun. It is envisaged that the combination of these technologies expectantly enhances the thrombus-free condition which starts immediately after implantation.

  • Research Products

    (6 results)

All 2005

All Journal Article (6 results)

  • [Journal Article] Mesoscopic spatial designs of nano- and micron-Fiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques.2005

    • Author(s)
      S.Kidoaki, I.K.Kwon, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 37-46

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Electrospun nano- to microfiber fabrics made of biodegradable copolyesters : structural characteristics, mechanical properties and cell adhesion potential.2005

    • Author(s)
      I.K.Kwon, S.Kidoaki, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 3239-3939

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics.2005

    • Author(s)
      T.Matsuda, M.Ihara, H.Inoguchi, K.I1 K.Kwon, K.Takamizawa
    • Journal Title

      J Biomed Mater Res PartA 73A

      Pages: 125-131

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Mesoscopic spatial designs of nano- and micron-fiber meshes for tissue-engineering matrix and scaffold based on newly devised multilayering and mixing electrospinning techniques.2005

    • Author(s)
      S.Kidoaki, I.K.Kwon, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 37-46

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Electrospun nano- to microfiber fabrics made of biodegradable copolyesters : structural characteristics, mechanical properties and cell adhesion potential.2005

    • Author(s)
      K.Kwon, S.Kidoaki, T.Matsuda
    • Journal Title

      Biomaterials 26

      Pages: 3239-3939

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mechano-active scaffold design of small-diameter artificial graft made of electrospun segmented polyurethane fabrics.2005

    • Author(s)
      T.Matsuda, M.Ihara, H.Inoguchi, K.Il K.Kwon, K.Takamizawa
    • Journal Title

      J Biomed Mater Res PartA 73A

      Pages: 125-131

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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