2005 Fiscal Year Final Research Report Summary
Strategic Autonomic Nervous Control Using Artificial Brainstem to Cope With Obstinate Cardiovascular Diseases
| Project/Area Number |
15200040
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | KYUSHU UNIVERSITY (2004-2005)
National Cardiovascular Center Research Institute (2003) |
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Principal Investigator |
SUNAGAWA Kenji Kyushu University, Graduate School of Medicine, Medical Sciences, Professor, 大学院・医学研究院, 教授 (50163043)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIMACHI Masaru National Cardiovascular Center research Institute, Department of Cardiovascular Dynamics, Director, 循環動態機能部, 部長 (40250261)
KAWADA Toru National Cardiovascular Center research Institute, Department of Cardiovascular Dynamics, Laboratory chief, 循環動態機能部, 室長 (30243752)
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| Project Period (FY) |
2003 – 2005
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| Keywords | bionic medicine / electronic therapy / cute myocardial infarction / heart failure / cardiac remodeling / vagus / ortic depressor nerve / arterial baroreflex |
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| Research Abstract |
In this study we demonstrated that controlling the autonomic tone arbitrarily by using an electronic artificial brainstem reduced the mortality and inhibited cardiac remodeling in the ischemia-induced heart failure model. In the electronic therapy targeting the vagus, a combination of the electronic treatment with beta-adrenergic inhibition showed more significant improvement, suggesting that the vagal effects are different from the beta-adrenergic inhibition. In the electronic therapy targeting the arterial baroreflex afferent pathway, vagotomy reduced the improvement of survival rate after acute myocardial ischemia, suggesting the importance of the vagal efferent pathway. Next, we speculated that anti-inflammatory effects through the abdominal vagus might contribute to the improvement of heart failure, and performed the electronic therapy in animals with abdominal vagal transection. The results indicate that the abdominal vagi contribute to the improvement of hemodynamics but not to
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the improvement of survival after myocardial ischemia. In parallel with these therapeutic experiments, we identified the dynamic characteristics of baroreceptor transduction and developed a new identification method for the arterial baroreflex central function. These studies should provide a basis necessary for integration of the artificial brainstem into the biological systems.
The above-mentioned bionic medicine using the artificial brainstem is a fusion of the state-of-the-art medicine and the cutting-edge engineering, and is unique in the medical history. Because the bionic medicine was able to improve the prognosis of heart failure via mechanisms different from ordinary pharmacological treatments of sympathetic inhibition, the present therapeutic strategy should have a great impact on the current medicine. Heart failure is a greatest medical agenda both socially and financially in advanced countries. Clinical application of the present research results is expected not only to cure patients but also to promote the economical efficiency in the society, directly leading to the invention of intellectual properties and new industries. Less
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[Journal Article] Automated drug delivery system to control systemic arterial pressure, cardiac output, and left heart filling pressure in acute decompensated heart failure.2006
Author(s)
Uemura K, Kamiya A, Hidaka I, Kawada T, Shimizu S, Shishido T, Yoshizawa M, Sugimachi M, Sunagawa K.
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Journal Title
J Appl Physiol. 100
Pages: 1278-1286
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Short-term electroacupuncture at Zusanli resets the arterial baroreflex neural arc toward lower sympathetic nerve activity.2006
Author(s)
Michikami D, Kamiya A, Kawada T, Inagaki M, Shishido T, Yamamoto K, Ariumi H, Iwase S, Sugenoya J, Sunagawa K, Sugimachi M.
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Journal Title
Am J Physiol Heart Circ Physiol. (in press)
Description
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[Journal Article] Resetting of the arterial baroreflex increases orthostatic sympathetic activation and prevents postural hypotension in rabbits.2005
Author(s)
Kamiya A, Kawada T, Yamamoto K, Michikami D, Ariumi H, Uemura K, Zheng C, Shimizu S, Aiba T, Miyamoto T, Sugimachi M, Sunagawa K.
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Journal Title
J Physiol. 566
Pages: 237-246
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia.2005
Author(s)
Kamiya A, Hayano J, Kawada T, Michikami D, Yamamoto K, Ariumi H, Shimizu S, Uemura K, Miyamoto T, Aiba T, Sunagawa K, Sugimachi M.
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Journal Title
Am J Physiol Heart Circ Physiol. 289
Pages: H1758-H1769
Description
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[Journal Article] Dynamic and static baroreflex control of muscle sympathetic nerve activity (SNA) parallels that of renal and cardiac SNA during physiological change in pressure.2005
Author(s)
Kamiya A, Kawada T, Yamamoto K, Michikami D, Ariumi H, Miyamoto T, Shimizu S, Uemura K, Aiba T, Sunagawa K, Sugimachi M.
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Journal Title
Am J Physiol Heart Circ Physiol. 289
Pages: H2641-H2648
Description
「研究成果報告書概要(欧文)」より
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