Intensive study for realization of the next-generation brain PET system with high sensitivity, high spatial resolution and high speed

2005 Fiscal Year Final Research Report Summary

• Project/Area Number: 15200043
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical systems
• Research Institution: National Institute of Radiological Sciences
• Principal Investigator: MURAYAMA Hideo National Institute of Radiological Sciences, Department of Medical Physics, Head of Imaging Physics, 医学物理部, 研究員 (50166310)
• Co-Investigator(Kenkyū-buntansha): TANADA Shuji National Institute of Radiological Sciences, Department of Medical Imaging, Head of Medical Imaging, 画像医学部, 研究員 (40116950) ; KAWAI Hideyuki Chiba University, Department of Physics, Associate Professor, 理学部, 助教授 (60214590) ; HANEISHI Hideaki Chiba University, Department of Information and Image Sciences, Associate Professor, 工学部, 助教授 (20228521) ; HASEGAWA Tomoyuki Kitasato University, Department of Allied Health Sciences, Assistant, 医療衛生学部, 講師 (10276181) ; OBI Takashi Tokyo Institute of Technology, Imaging Science and Engineering Laboratory, Assistant, 工学部, 助教授 (40280995)
• Project Period (FY): 2003 – 2005
• Keywords: PET / nuclear medicine / Instrumentation for diagnosis / scintillation detector / coincident count / radioisotope / image reconstruction / medical imaging

Research Abstract

Key technologies to realize the next-generation PET system with high sensitivity, high spatial resolution and high speed has been studied. We have developed growing technology of large gadolinium silicate (GSO) single crystals with a diameter of 100 mm. In our depth-of-interaction (DOI) detector, we can control the behavior of scintillation photons by inserting the reflector between crystal elements. The determination of the crystal of the interaction is performed on a two-dimensional histogram mapped by Anger-type positioning arithmetic calculation with output signals from PS-PMT optically coupled to the crystal array. A high-performance brain DOI-PET scanner, jPET-D4, has been developed at NIRS. This scanner was designed to achieve not only high spatial resolution but also high sensitivity using four-layered DOI detectors. The scanner has five detector rings with the ring diameter of 390mm and each detector ring consists of 24 DOI detectors. Each DOI detector consists of 1,024 GSO crystals, which are arranged in four layers of 16 x 16 arrays, coupled to a 52 mm square 256ch position sensitive PMT (FP-PMT). The crystal elements are 2.9 x 2.9 x 7.5 mm^3. The crystals of layer-1, 2 and layer-3, 4 are GSO doped with 0.5 mol% and 1.5 mol% Ce, respectively. The sensitivity at the center of FOV is 112 kcps/MBq and spatial resolution is less than 3 mm all over the FOV.

Research Products

• [Journal Article] Energy spectra analysis of the four-layer DOI detector for the brain PET scanner : jPET-D4. (2006)
  • Author(s): Yoshida, E., Kitamura, K., Tsuda, T., Shibuya, K., Yamaya, T., Inadama, N., Hasegawa, T., Murayama, H.
  • Journal Title: Nucl.Instr.Meth.A 577 Pages: 664-669
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Depth-of-interaction recognition using optical filters for nuclear medicine imaging. (2005)
  • Author(s): Hasegawa, T
  • Journal Title: IEEE Trans. Nucl. Sci. 52(1) Pages: 4-7
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Performance of a 256ch Flat Panel PS-PMT with small crystals for a DOI PET detector. (2005)
  • Author(s): Inadama, N
  • Journal Title: IEEE Trans. Nucl. Sci., 52(1) Pages: 15-20
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A block detector for a multislice, depth-of-interaction MR-compatible PET. (2005)
  • Author(s): Yamamoto, S.
  • Journal Title: IEEE Trans. Nuci. Sci., 52(1) Pages: 33-37
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] 小動物用DOI-PET装置"jPET-RD"の2次元イメージングシミュレーション (2005)
  • Author(s): 山谷泰賀
  • Journal Title: 医学物理 25(1) Pages: 13-23
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Transaxial system models for jPET-D4 image reconstruction. (2005)
  • Author(s): Yamaya, T
  • Journal Title: Phys. Med. Biol., 50 Pages: 5339-5355
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Preliminary evaluation of 4-layer BGO DOI-detector for PET (2005)
  • Author(s): Inadama, N.
  • Journal Title: IEEE Trans. Nucl. Sci. 53(1) Pages: 30-34
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Depth-of-interaction recognition using optical filters for nuclear medicine imaging. (2005)
  • Author(s): Hasegawa, T., Ishikawa, M., Maruyama, K., Inadama, N., Yoshida, E., Murayama, H.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 4-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Three-dimensional array of scintillation crystals with proper reflector arrangement for a depth of interaction detector. (2005)
  • Author(s): Orita, N., Murayama, H., Kawai, H., Inadama, N., Tsuda, T.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 8-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Performance of a 256ch Flat Panel PS-PMT with small crystals for a DOI PET detector. (2005)
  • Author(s): Inadama, N., Murayama, H., Watanabe, M., Omura, T., Yamashita, T., Kawai, H., Orita, N., Tsuda, T.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 15-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A block detector for a multislice, depth-of-interaction MR-compatible PET. (2005)
  • Author(s): Yamamoto, S., Takamatsu, S., Murayama, H., Minato, K.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 33-37
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Performace of prototype liquid xenon scintillation detector system for time-of-flight type positron emission tomography with improved photomultipliers. (2005)
  • Author(s): Nishikido, F., Doke, T., Kikuchi, J., Mori, T., Murayama, H., Ooshita, T., Takahashi, H.
  • Journal Title: Jpn.J.Appl.Phys. 44(7A) Pages: 5193-5198
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transaxial system models for jPET-D4 image reconstruction. (2005)
  • Author(s): Yamaya, T., Hagiwara, N., Obi, T., Yamaguchi, M., Ohyama, N., Kitamura, K., Hasegawa, T., Haneishi, H., Yoshida1, E., Naoko Inadama, N., Murayama, H.
  • Journal Title: Phys.Med.Biol. 50 Pages: 5339-5355
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Investigation of the effects of inter-crystal scatter reduction on reconstructed images in the jPET-D4 scanner. (2005)
  • Author(s): Lam, C.F., Hagiwara, N., Obi, T., Yamaguchi, M., Haneishi, H., Tsuda, T., Yoshida, E., Yamaya, T., Murayama, H.
  • Journal Title: Med.Imag.Tech. 23(5) Pages: 318-327
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Preliminary evaluation of 4-layer BGO DOI-detector for PET. (2005)
  • Author(s): Inadama, N., Murayama, H., Kitamura, K., Inadama, N., Yamaya, T., Yashida, E., Nishikido, F., Hamamoto, M., Kawai, H., Ono, Y.
  • Journal Title: IEEE Trans.Nucl.Sci. 53(1) Pages: 30-34
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Performance evaluation of a subset of a four-layer LSO detector for a small animal DOI PET scanner : jPET-RD. (2005)
  • Author(s): Tsuda, T., Murayama, H., Kitamura, K., Yamaya, T., Yoshida, E., Omura, T., Kawai, H., Inadama, N., Orita, N.
  • Journal Title: IEEE Trans.Nucl.Sci. 53(1) Pages: 35-39
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] On-clock non-paralysable count-loss model. (2004)
  • Author(s): Hasegawa, T.
  • Journal Title: Phys. Med. Biol. 49(4) Pages: 547-555
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Performance of a PET detector with a 256ch flat panel PS-PMT. (2004)
  • Author(s): Inadama, N.
  • Journal Title: IEEE Trans. Nucl. Sci 51(1) Pages: 58-62
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Calibration Procedure for a DOI Detector of High Resolution PET through Mixture Gaussian Model. (2004)
  • Author(s): Yoshida, E.
  • Journal Title: IEEE Trans. Nucl. Sci. 51(5) Pages: 2537-2542
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] A Four Lavers Depth of Interaction Detector Block for Small Animal PET. (2004)
  • Author(s): Tsuda, T.
  • Journal Title: IEEE Trans. Nucl. Sci. 51(5) Pages: 2537-2542
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] On-clock non-paralysable count-loss model. (2004)
  • Author(s): Hasegawa, T., Yoshida, E., Yamaya, T., Maruyama, H., Murayama, H.
  • Journal Title: Phys.Med.Biol. 49(4) Pages: 547-555
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Performance of a PET detector with a 256ch flat panel PS-PMT. (2004)
  • Author(s): Inadama, N., Murayama, H., Watanabe, M., Omura, T., Yamashita, T., Kawai, H., Umehara, T., Kasahara, T., Orita, N., Tsuda, T.
  • Journal Title: IEEE Trans.Nucl.Sci. 51(1) Pages: 58-62
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Large GSO single crystals with a diameter of 100 mm and their scintillation performance. (2004)
  • Author(s): Kurashige, K., Gunji, A., Kamada, M., Shimura, N., Ishibashi, H., Yoshida, K., Senguttuvan, N., Sumiya, K., Shimizu, S., Murayama, H.
  • Journal Title: IEEE Trans.Nucl.Sci. 51(3) Pages: 742-745
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Calibration Procedure for a DOI Detector of High Resolution PET through Mixture Gaussian Model. (2004)
  • Author(s): Yoshida, E., Y.Kimura, Y., K.Kitamura, K., Murayama, H.
  • Journal Title: IEEE Trans.Nucl.Sci. 51(5) Pages: 2543-2549
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Four Layers Depth of Interaction Detector Block for Small Animal PET. (2004)
  • Author(s): Tsuda, T., Murayama, H., Kitamura, K., Yamaya, T., Yoshida, E., Omura, T., Kawai, H., Inadama, N., Orita, N.
  • Journal Title: IEEE Trans.Nucl.Sci. 51(5) Pages: 2537-2542
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a high resolution APD based animal PET and multi-channel waveform-sampling front-end ASIC, (2004)
  • Author(s): Yeom, JY., Takahashi, H., Ishitsu, T., Nakazawa, M., Murayama, H.
  • Journal Title: Journal of Nuclear Science and Technology Supplement4 Pages: 279-282
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a multi-channel Waveform Sampling ASIC for Animal PET with DOI Information, (2004)
  • Author(s): Yeom, JY., Takahashi, H., Ishitsu, T., Nakazawa, M., Murayama, H.
  • Journal Title: Nucl.Instr. and Meth. A525 Pages: 221-224
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Depth-of-interaction Recognition Using Optical Filters for Nuclear Medicine Imaging. (2004)
  • Author(s): Hasegawa, T., Muramoto, T., Kato, Y., Ishikawa, M., Inadama, N., Yoshida, E., Murayama, H.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 4-7
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A Four Layers Depth of Interaction Detector Block for Small Animal PET. (2004)
  • Author(s): Orita, N., Murayama, H., Kawai, H., Inadama, N., Tsuda, T.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 8-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Performance of a 256ch Flat Panel PS-PMT with small crystals for a DOI PET detector. (2004)
  • Author(s): Inadama, N., Murayama, H.., Watanabe, M., Omura, T., Yamashita, T., Kawai, H., Orita, N., Tsuda, T.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 15-20
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A block detector for a multi-slice depth of interaction MR-compatible PET. (2004)
  • Author(s): Yamamoto, S., Murayama, H.
  • Journal Title: IEEE Trans.Nucl.Sci. 52(1) Pages: 33-37
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of Mg-, Zr-, and Ta-doping on scintillation properties of Gd2SiO5:Ce crystal. (2003)
  • Author(s): Shimizu, S., Sumiya, K., Ishibashi, H., Senguttvan, N., Redkin, BS., Ishii, M., Kobayashi, M., Susa, K., Murayama, H.
  • Journal Title: IEEE Trans.Nucl.Sci. 50(4) Pages: 778-781
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Improvement of the depth of interaction detector for PET on full energy pulse height uniformity. (2003)
  • Author(s): Kasahara, T., Murayama, H., Omura, T., Yamashita, T., Ishibashi, H., Kawai, H., Inadama, N., Umehara, T., Orita, N., Tsuda, T.
  • Journal Title: IEEE Trans.Nucl.Sci. 50(5) Pages: 1439-1444
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] DOI-PET image reconstruction with accurate system model reducing redundancy of imaging system. (2003)
  • Author(s): Yamaya, T., Hagiwara, N., Obi, T., Yamaguchi, K., Kita, K., Ohyama, N., Kitamura, K., Hasegawa, T., Haneishi, H., Murayama, H.
  • Journal Title: IEEE Trans.Nucl.Sci. 50(5) Pages: 1404-1409
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 平成16年度次世代PET装置開発研究報告書 (2005)
  • Author(s): 棚田修二, 村山秀雄
  • Publisher: 放射線医学総合研究所発行
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 平成15年度次世代PET装置開発研究報告書 (2004)
  • Author(s): 棚田修二, 村山秀雄
  • Publisher: 放射線医学総合研究所発行
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 平成14年度次世代PET装置開発研究報告書 (2003)
  • Author(s): 村田啓, 村山秀雄
  • Publisher: 放射線医学総合研究所発行
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 放射線入射位置3次元検出器の発行位置特定方法 (2005)
  • Inventor(s): 村山秀雄, 石橋浩之, 山下貴司, 内田博, 大村知秀
  • Industrial Property Number: 特許第3697340号
  • Filing Date: 2005-07-08
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 放射線位置検出方法及び装置 (2005)
  • Inventor(s): 稲玉直子, 村山秀雄, 澁谷憲悟, 北村圭司, 石橋浩之
  • Industrial Property Number: 特願2005-282866
  • Filing Date: 2005-09-28
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] Radiation three-dimensional position detector (2004)
  • Inventor(s): Murayama, H., Inadama, N., Kitamura, K., Yamashita, T.
  • Industrial Property Number: FPO3-0389-00US-HP(米国特許庁)
  • Filing Date: 2004-02-26
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 多段セル集合体の組立方法及びクランプ器具 (2004)
  • Inventor(s): 村山秀雄,稲玉直子,奥野敦,古沢孝
  • Industrial Property Number: 特願2004-269568
  • Filing Date: 2004-09-16
  • Description: 「研究成果報告書概要(和文)」より