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2006 Fiscal Year Final Research Report Summary

Fundamental research on design of nano-device using self-oscillating gel

Research Project

Project/Area Number 15205027
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Polymer/Textile materials
Research InstitutionThe University of Tokyo

Principal Investigator

YOSHIDA Ryo  The University of Tokyo, Graduate School of Engineering, Associate Professor, 大学院工学系研究科, 助教授 (80256495)

Project Period (FY) 2003 – 2006
KeywordsPolymer gel / N-isopropylacrylamide / Stimuli-responsive polymer / Self-oscillation / Belousov-Zhabotinsky reaction / Oscillating reaction / Nonlinear chemistry / Intelligent materials
Research Abstract

As a novel biomimetic polymer, we have been studying the polymer with an automonous self-oscillating function by utilizing oscillating chemical reactions. We succeeded in developing a novel self-oscillating polymer and gels by utilizing the Belousov-Zhabotinsky (BZ) reaction. The self-oscillating polymer is composed of poly(N-isopropylacrylamide) (PNIPAAm), in which Ru(bpy)_3 is incorporated as a catalyst for the BZ reaction. Under the coexistence of the reactants (malonic acid, sodium bromate, and nitric acid), the polymer undergoes spontaneous cyclic soluble-insoluble changes or swelling-deswelling changes (in the case of gel) without any on-off switching of external stimuli. To cause the self-oscillation of the polymer under physiological condition without utilizing non-biorelated BZ substrates, we have been attempting to construct the build-in system where the substrates other than organic acid are incorporated into the polymer itself. As the first step, acrylamide-2-methylpropanes … More ulfonic acid (AMPS) was incorporated into the poly(NIPAAm-co-Ru(bpy)_3) as the pH-control site. As the next step, we have attempted to introduce the oxidizing agent into the polymer. Methacrylamidopropyltrimethylammonium chloride (MAPTAC) with a positively charged group was incorporated into the poly(NIPAAm-co-Ru(bpy)_3) as a capture site for an anionic oxidizing agent (bromate ion). The bromate ion was introduced into the MAPTAC-containing polymer through ion-exchange process. By using the copolymer, self-oscillation only in the presence of organic acid was achieved. To synthesize an artificial biomachine with self-beating function which acts under physiological condition, we have developed another self-oscillating gel that can be driven by chemical energy of ATP decomposition. Anionic polymer gel with phosphoric groups, in which creatine kinase was immobilized, was prepared. When the gel was immersed in the ATP solution, the enzymatic reaction occurs in the gel and the concentration of calcium ion changes periodically. As a result, the gel repeats swelling and deswelling autonomously. Less

  • Research Products

    (38 results)

All 2006 2005 2004 2003

All Journal Article (37 results) Book (1 results)

  • [Journal Article] Dependence of turbidity oscillations of self-oscillating polymers on the selective recognition of the crown ether receptors contained in the polymer chain2006

    • Author(s)
      D.S.Huh, et al.
    • Journal Title

      J. Phys. Chem. B 110 (27)

      Pages: 13405-13409

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] AFM observation of immobilized self-oscillating polymer2006

    • Author(s)
      Y.Ito, et al.
    • Journal Title

      J. Phys. Chem. B 110 (11)

      Pages: 5170-5173

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Microfabrication of functional polymer gels and their application to novel biomimetic materials2006

    • Author(s)
      R.Yoshida, et al.
    • Journal Title

      J. Photopolymer Sci. Tech. 19 (4)

      Pages: 441-444

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Maskless microfabrication of thermosensitive gels using a microscope and application to a controlled release microchip2006

    • Author(s)
      R.Yoshida, et al.
    • Journal Title

      Lab on a Chip 6 (10)

      Pages: 1384-1386

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dependence of turbidity oscillations ofself-oscillating polymers on the selective recognition of the crown ether receptors contained in the polymer chain2006

    • Author(s)
      D.S.Huh, et al.
    • Journal Title

      J.Phys.Chem.B 110(27)

      Pages: 13405-13409

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] AFM observation of immobilized self-oscillating polymer2006

    • Author(s)
      Y.Ito
    • Journal Title

      J.Phys.Chem.B 110(11)

      Pages: 5170-5173

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Microfabrication of functional polymer gels and their application to novel biomimetic materials2006

    • Author(s)
      R.Yoshida et al.
    • Journal Title

      J.Photopolymer Sci.Tech. 19(4)

      Pages: 441-444

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Maskless microfabrication of thermosensitive gels using a microscope and application to a controlled release microchip2006

    • Author(s)
      R.Yoshida et al.
    • Journal Title

      Lab on a Chip 6(10)

      Pages: 1384-1386

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Dancing waves in reaction-diffusion systems2005

    • Author(s)
      Y.Abe, et al.
    • Journal Title

      J. Phys. Chem. A 109 (17)

      Pages: 3773-3776

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Self-oscillation of polymer chains induced by the Belousov-Zhabotinsky reaction under acid-free conditions2005

    • Author(s)
      Y.Hara, et al.
    • Journal Title

      J. Phys. Chem. B 109 (19)

      Pages: 9451-9454

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Phase transition behaviors of self-oscillating polymer and nano-gel particles2005

    • Author(s)
      T.Sakai, et al.
    • Journal Title

      Macromol. Rapid Commun. 26

      Pages: 1140-1144

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Control of oscillating behavior for the self-oscillating polymer with pH-control site2005

    • Author(s)
      Y.Hara, et al.
    • Journal Title

      Langmuir 21 (21)

      Pages: 9773-9776

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Biomimetic gel exhibiting self-beating motion in ATP solution2005

    • Author(s)
      R.Yoshida, et al.
    • Journal Title

      Biomacromolecules 6 (6)

      Pages: 2923-2926

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Design of surfactant-grafted hydrogels with fast response to emperature2005

    • Author(s)
      Y.Noguchi, et al.
    • Journal Title

      Macromol. Rapid Commun. 26

      Pages: 1913-1917

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Self-oscillating soluble-insoluble changes of polymer chain including an oxidizing agent induced by the Belousov-Zhabotinsky reaction2005

    • Author(s)
      Y.Hara, et al.
    • Journal Title

      J. Phys. Chem. B 109 (49)

      Pages: 23316-23319

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Design of functional polymer gels and their application to biomimetic materials2005

    • Author(s)
      R.Yoshida
    • Journal Title

      Curr. Org. Chem. 9

      Pages: 1617-1641

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Dancing waves in reaction-systems2005

    • Author(s)
      Y.Abe et al.
    • Journal Title

      J.Phys.Chem.A 109(17)

      Pages: 3773-3776

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Self-oscillation of polymer chains induced by the Belousov-Zhabotinsky reaction under acid-free conditions2005

    • Author(s)
      Y.Hara et al.
    • Journal Title

      J.Phys.em.B 109(19)

      Pages: 9451-9454

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Phase transition behaviors of self-oscillating polymer and nano-gel particles2005

    • Author(s)
      T.Sakai et al.
    • Journal Title

      Marcomol.Rapid Commun. 26

      Pages: 1140-1144

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Control of oscillating behavior for the self-oscillating polymer with pH-control site2005

    • Author(s)
      Y.Hara et al.
    • Journal Title

      Langmuir 21(21)

      Pages: 9773-9776

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Biomimetic gel exhibiting sdf-beating motion in ATP solution2005

    • Author(s)
      R.Yoshida
    • Journal Title

      Biomacromolecules 6(6)

      Pages: 2923-2926

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Design of surfactant-grafted hydrogels with fast response to temperature2005

    • Author(s)
      Y.Noguchi et al.
    • Journal Title

      Marcomol.Rapid Commun. 26

      Pages: 1913-1917

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Self-oscillating soluble-insoluble changes of polymer chain including an oxidizing agent induced by the Belousov-Zhabotinsky reaction2005

    • Author(s)
      Y.Hara
    • Journal Title

      J.Phys.Chem.B 109(49)

      Pages: 23316-23319

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Design of functional polymer gels and their application to biomimetic materials2005

    • Author(s)
      R.Yoshida
    • Journal Title

      Curr.g.Chem. 9

      Pages: 1617-1641

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Self-oscillating nanogel particles2004

    • Author(s)
      T.Sakai, et al.
    • Journal Title

      Langmuir 20 (4)

      Pages: 1036-1038

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety operating at the physiological pH2004

    • Author(s)
      A.Matsumoto, et al.
    • Journal Title

      Biomacromolecules 5

      Pages: 1038-1045

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Self-oscillating nanogel particles2004

    • Author(s)
      T.Sakai et al.
    • Journal Title

      Langmuir 20(4)

      Pages: 1036-1038

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety operating at the physiological pH2004

    • Author(s)
      A.Matsumoto et al.
    • Journal Title

      Biomacromolecules 5

      Pages: 1038-1045

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Polymer gels2004

    • Author(s)
      R.Yoshida
    • Journal Title

      Kobunshi senran zairyo One point 2,Kyoritsu Shuppan

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Self-beating motion of gels and modulation of oscillation rhythm synchronized with organic acid2003

    • Author(s)
      R.Yoshida, et al.
    • Journal Title

      Macromolecules 36 (6)

      Pages: 1759-1761

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Mechanical oscillation coupled with the Belousov-Zhabotinsky reaction in gel2003

    • Author(s)
      S.Sasaki, et al.
    • Journal Title

      Langmuir 19 (14)

      Pages: 5595-5600

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Temperature control of the Belousov-Zhabotinsky reaction using a thermo-responsive polymer2003

    • Author(s)
      Y.Ito, et al.
    • Journal Title

      Langmuir 19 (23)

      Pages: 9577-9579

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Self-sustaining peristaltic motion on the surface of a porous gel2003

    • Author(s)
      Y.Takeoka, et al.
    • Journal Title

      J. Am. Chem. Soc. 125 (44)

      Pages: 13320-13321

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Self-beating motion of gels and modulation of oscillation rhythm synchronized with organic acid2003

    • Author(s)
      R.Yoshida et al.
    • Journal Title

      Macromolecules 36(6)

      Pages: 1759-1761

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Mechanical oscillation coupled with the Belousov-Zhabotinsky reaction in gel2003

    • Author(s)
      S.Sasaki
    • Journal Title

      Langmuir 19(14)

      Pages: 5595-5600

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Temperature control of the Belousov-Zhabotinsky reaction using a thermo-responsive polymer2003

    • Author(s)
      Y.Ito et al.
    • Journal Title

      Langmuir 19(23)

      Pages: 9577-9579

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Self-sustaining peristaltic motion on the surface of a porous gel2003

    • Author(s)
      Y.Takeoka et al.
    • Journal Title

      J.Am.Chem.Soc. 125(44)

      Pages: 13320-13321

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 高分子先端材料 One Point 2高分子ゲル2004

    • Author(s)
      吉田 亮
    • Total Pages
      131
    • Publisher
      共立出版
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2008-05-27  

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