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2005 Fiscal Year Final Research Report Summary

Applying ferrite nanobeads to medical diagnosis, therapy and analysis

Research Project

Project/Area Number 15209019
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionTokyo Institute of Technology

Principal Investigator

ABE Masanori  Tokyo Institute of Technology, Department of Physical Electronics, Professor, 大学院・理工学研究科, 教授 (70016624)

Co-Investigator(Kenkyū-buntansha) HANDA Hiroshi  Tokyo Institute of Technology, Department of Biologiral Information Science, Professor, 大学院・生命理工学研究科, 教授 (80107432)
HIBI Norifumi  Keio University, Department of Internal Medicine, Professor, 医学部, 教授 (50129623)
Project Period (FY) 2003 – 2005
KeywordsMagnetic beads / Bio-screening / Bio-sensing / MRI contrast agent / Hyperthermia / Anticancer drug / DNA / Ferrite nanobeads
Research Abstract

1. Development of size controlled ferrite nanobeads
Iron-ferrite nanoparticles with controlled size of 10-100 nm were successfully synthesized by our newly developed methods called co-precipitation, partial-oxidation, and seed-growth methods.
2. Development of functional-polymer coated ferrite nanobeads
The iron-ferrite nanoparticles were successfully coated with poly-GMA, which exhibits minimal non-specific adsorption of proteins, by a co-polymerization method and a novel, soap-free polymerization method.
3. Development of polymer coated iron nanobeads
Metallic iron nanoparticles (7-20 nm in size), which have magnetization two times stronger than that of ferrite particles and are advantageous for magnetic separation in bio-screening, were successfully coated with poly-GMA.
4. Application to analysis by bio-screening system
The poly-GMA coated ferrite nanobeads were conjugated with physiologically active substances such as anticancer antibodies and recombinant proteins containing tagged Prote … More in-G. Utilizing the beads, we successfully captured physiologically active substances that are complementary to those conjugated onto the beads. This revealed our beads are fitted for magnetic carriers for high throughput bio-screening.
5. Application to diagnosis by Hall bio-sensing
poly-GMA coated ferrite nanobeads were conjugated with single strand DNA, which were immobilized onto the surface of a Hall sensor via hybridization with the complementary DNA single strand fixed on the sensor surface. This revealed our beads are applicable to magnetic carriers for DNA analysis.
6. Application to diagnosis by contrast enhanced MRI
We successfully modified the surfaces of the ferrite nanobeads with a variety of functional molecules, and discovered candidate materials for high performance MRI contrast agent.
7. Application to anticancer magnetic hyperthermia
Utilizing the ferrite nanobeads as heat source by magnetic-field induction at an non-invasive frequency of 120 kHz, we successfully killed human colon cancer cells. We thus revealed that our beads are applicable to magnetic carriers for non-invasive, anticancer magnetic hyperthermia. Less

  • Research Products

    (68 results)

All 2006 2005 2004 2003 2002 Other

All Journal Article (62 results) Book (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] The VP2/VP3 minor capsid protein of SV40 promotes the in vitro assembly of the major capsid protein VP1 into particles2006

    • Author(s)
      Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R.U., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K., Handa, H.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 10164-10173

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening2006

    • Author(s)
      Funabashi, H., Tanaka, Y., Imamura, Y., Mie, M., Manabe, T., Tanaka, H., Takahashi, Takashi, Handa, H., Aizawa, M., Kobatake, E.
    • Journal Title

      Biosens Bioelectron. 21

      Pages: 1675-1683

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The VP2/VP3 minor capsid ptotein of SV40 promotes the in vitro assembly of the major capsid protein VP1 into particles.2006

    • Author(s)
      Kawano, M., Inoue, T., Tsukamoto, H., Takaya, T., Enomoto, T., Takahashi, R.U., Yokoyama, N., Yamamoto, N., Nakanishi, A., Imai, T., Wada, T., Kataoka, K., Handa, H.
    • Journal Title

      J.Biol.Chem. 281

      Pages: 10164-10173

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Glucose oxidase assisted homogeneous electrochemical receptor binding assay for drug screening2006

    • Author(s)
      Funabashi, H., Tanaka, Y., Imamura, Y, Mie.M., Manabe, T., Tanaka, H., Takahashi, Takashi., Handa, H., Aizawa, M., Kobatake, E.
    • Journal Title

      Biosens Bioelectron. 21

      Pages: 1675-1683

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 医用磁性ナノビーズの新しい作製技術2005

    • Author(s)
      阿部, 正紀, 半田, 宏
    • Journal Title

      応用物理 74・12

      Pages: 1580-1583

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel Medical Ferrite Nanobeads with Bioactive Molecules Immobilized Strongly onto the Surfaces2005

    • Author(s)
      Abe, M., Matsushita, N., Shimazu, R., Tada, M., Gokon, N., Nishio, K., Handa, H.
    • Journal Title

      Mater. Res. Soc. Symp. Proc. 877E

      Pages: S8-2

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Superparamagnetic Beads2005

    • Author(s)
      A.Lapicki, H.Sanbonsugi, T.Yamamura, N.Matsushita, M.Abe, H.Narimatsu, H.Handa, A.Sandhu
    • Journal Title

      IEEE Trans. Magn. Soc. 41, 10

      Pages: 4134-4136

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] FMR Study on Spin-Sprayed Ni-Zn-Co Ferrite Films with High Permeability Usable for GHz Noise Suppressors2005

    • Author(s)
      K.Kondo, T.Chiba, S.Yoshida, S.Okamoto, Y.Shimada, N.Matsushita, A.Abe
    • Journal Title

      IEEE Trans. Magn. Soc 41, 10

      Pages: 3463-3465

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Expediting Magnetic Separation Using Ni Wires, Applicable for Robot-Manipulated Bio-Screening systems2005

    • Author(s)
      Shimazu, R., Tada, M., Matsushita, N., Handa, H., Abe, M.
    • Journal Title

      IEEE Trans. Magn. Soc. 41, 10

      Pages: 4117-4119

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Styrene-Coated Iron Nanobeads for Medical Use2005

    • Author(s)
      Kuroda, C.S., Maeda, M., Nishibiraki, H., Matsushita, N., Handa, H., Abe, M.
    • Journal Title

      IEEE Trans. Magn. Soc. 41, 10

      Pages: 4143-4145

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Preparlation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening2005

    • Author(s)
      Nishibiraki, H., Kuroda, C.S., Maeda, M., Matsushita, N., Abe, M., Handa, H.
    • Journal Title

      JOURNAL OF APPLIED PHYSICS 97

      Pages: 10Q919,1-3

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Superparamagnetic Beads2005

    • Author(s)
      Adam LAPICKI, Hideaki SANBONSUGI, Takuya YAMAMURA, Nobuhiro MATSUSHITA, Masanori ABE, Hiroki NARIMATSU, Hiroshi HANDA, Adarsh SANDHU
    • Journal Title

      IEEE Trans. Magn. Soc 41, 10

      Pages: 4134-4136

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Affinity Identification of o Opioid Receptors Using Latex Nanoparticles2005

    • Author(s)
      Hasegawa, M., Ohno, H., Tanaka, H., Hatakeyama, M., Kawaguchi, H., Takahashi, T., Handa, H.
    • Journal Title

      Bioorg. Med. Chem. Lett. 16

      Pages: 158-161

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Development of polymer latex particles for selctive cleavage of mismatched DNA and their application for DNA diagnosis.2005

    • Author(s)
      Oba, S., Hatakeyama, M., Handa, H., Kawaguchi, H.
    • Journal Title

      Bioconjugate Chemistry 16

      Pages: 551-558

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Polymer coating of ferrite nanoparticles by using "connecter" chemical compounds.2005

    • Author(s)
      Tsubouchi, S., Nishio, K., Ikeda, M., Narimatsu, H., Gokon, N., Handa, H., Abe, M.
    • Journal Title

      Proceedings of the Ninth International Conference on Ferrites (ICF-9)

      Pages: 499-454

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Selective ligand purification using high-performance affinity beads.2005

    • Author(s)
      Ohtsu, Y., Ohba, R., Imamura, Y., Kobayashi, M., Hatori, H., Zenkoh, T., Hatakeyama, M., Manabe, T., Hino, M., Yamaguchi, Y., Kataoka, K., Kawaguchi, H., Watanabe, H., Handa, H.
    • Journal Title

      Anal. Biochem. 338

      Pages: 245-252

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Abnormally differentiated subsets of intestinal macrophage play a key role in Thl-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.2005

    • Author(s)
      Kamada N., Hisamatsu T., Okamoto S., Sato T., Matsuoka K., Arai K., Nakai T., Hasegawa A., Inoue N., Watanabe N., Akagawa KS., Hibi T.
    • Journal Title

      J Immunol 175

      Pages: 6900-6908

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response.2005

    • Author(s)
      Sato T, Nakai T, Tamura N, Okamoto S., Matsuoka K, Sakuraba A., Fukushima T, Uede T., Hibi T
    • Journal Title

      Gut 54

      Pages: 1254-62

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel Medical Ferrite Nanobeads with Bioactive Molecules Immobilized Strongly onto the Surfaces2005

    • Author(s)
      Abe, M., Matsushita, N., Shimazu, R., Tada, M., Gokon, N., Nishio, K., Handa, H.
    • Journal Title

      Mater.Res.Soc.Symp.Proc. 877E

      Pages: S8-2

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Superparamagnetic Beads2005

    • Author(s)
      A.Lapicki, H.Sanbonsugi, T.Yamamura, N.Matsushita, M.Abe, H.Narimatsu, H.Handa, A.Sandhu
    • Journal Title

      IEEE Trans.Magn.Soc. 41,10

      Pages: 4134-4136

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] FMR Study on Spin-Sprayed Ni-Zn-Co Ferrite Films with High Permeability Usable for GHz Noise Suppressors2005

    • Author(s)
      K.Kondo, T.Chiba, S.Yoshida, S.Okamoto, Y.Shimada, N.Matsushita, M.Abe
    • Journal Title

      IEEE Trans.Magn.Soc. 41,10

      Pages: 3463-3465

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Expediting Magnetic Separation Using Ni Wires, Applicable for Robot-Manipulated Bio-Screening Systems2005

    • Author(s)
      Shimazu, R., Tada, M., Matsushita, N., Handa, H., Abe, M.
    • Journal Title

      IEEE Trans.Magn.Soc. 41,10

      Pages: 4117-4119

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Styrene-Coated Iron Nanobeads for Medical Use2005

    • Author(s)
      Kuroda, C.S., Maeda, M., Nishibiraki, H., Matsushita, N., Handa, H., Abe, M.
    • Journal Title

      IEEE Trans.Magn.Soc. 41,10

      Pages: 4143-4145

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] High-Sensitivity InSb Thin-Film Micro-Hall Sensor Arrays for Simultaneous Multiple Detection of Magnetic Beads for Biomedical Applications2005

    • Author(s)
      Kiyoshi Togawa, Hideaki Sanbonsugi, Adam Lapicki, Masanori Abe, Hiroshi Handa, Adarsh Sandhu
    • Journal Title

      IEEE Trans.Magn.Soc. 41,10

      Pages: 3661-3663

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Preparlation of medical magnetic nanobeads with ferrite particles encapsulated in a polyglycidyl methacrylate (GMA) for bioscreening2005

    • Author(s)
      Nishibiraki, H., Kuroda, C.S., Maeda, M., Matsushita, N., Abe, M., Handa, H.
    • Journal Title

      JOURNAL OF APPLIED PHYSICS 97,10Q919

      Pages: 1-3

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Functionalization of Micro-Hall Effect Sensors for Biomedical Applications Utilizing Supernaramarnetic Beads2005

    • Author(s)
      Adam LAPICKI, Hideaki SANBONSUGI, Takuya YAMAMURA, Nobuhiro MATSUSHITA, Masanori ABE, Hiroki NARIMATSU, Hiroshi HANDA, Adarsh SANDHU
    • Journal Title

      IEEE Trans.Magn.Soc. 41,10

      Pages: 4134-4136

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Practical Hall Sensors for Biomedical Instrumentation2005

    • Author(s)
      Sandhu, A., Handa.H.
    • Journal Title

      IEEE Trans Magn 41

      Pages: 4123-4127

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Affinity Identification of δ Opioid Receptors Using Latex Nanoparticles2005

    • Author(s)
      Hasegawa, M., Ohno, H., Tanaka, H., Hatakeyama, M., Kawaguchi, H., Takahashi, T., Handa, H
    • Journal Title

      Bioorg.Med.Chem.Lett. 16

      Pages: 158-161

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of polymer latex particles for selctive cleavage of mismatched DNA and their application for DNA diagnosis.2005

    • Author(s)
      Oba, S., Hatakeyama, M., Handa, H, Kawaguchi, H.
    • Journal Title

      Bioconjugate Chemistry 16

      Pages: 551-558

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Polymer coating of ferrite nanoparticles by using "connecter" chemical compounds.2005

    • Author(s)
      Tsubouchi, S., Nishio, K., Ikeda, M., Narimatsu, H., Gokon, N., Handa, H.Abe, M.
    • Journal Title

      Proceedings of the Ninth International Conference on Ferrites (ICF-9)

      Pages: 499-454

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Selective ligand purification using high-performance affinity beads.2005

    • Author(s)
      Ohtsu, Y., Ohba, R., Imamura, Y., Kobayashi, M., Hatori, H., Zenkoh, T., Hatakeyama, M., Manabe, T., Hino, M., Yamaguchi, Y, Kataoka, K., Kawaguchi, H., Watanabe, H., Handa, H.
    • Journal Title

      Anal.Biochem. 338

      Pages: 245-252

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Abnormally differentiated subsets of intestinal macrophage play a key role in Th1-dominant chronic colitis through excess production of IL-12 and IL-23 in response to bacteria.2005

    • Author(s)
      Kamada N, Hisamatsu T, Okamoto S, Sato T, Matsuoka K, Arai K, Nakai T, Hasegawa A, Inoue N, Watanabe N, Akagawa KS, Hibi T
    • Journal Title

      J.Immunol 175

      Pages: 6900-6908

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response.2005

    • Author(s)
      Sato T, Nakai T, Tamura N, Okamoto S, Matsuoka K, Sakuraba A, Fukushima T, Uede T, Hibi T
    • Journal Title

      Gut 54

      Pages: 1254-1262

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel preparation method of magnetic nanobeads for medical use.2005

    • Author(s)
      Abe, M., Handa, H.
    • Journal Title

      Oyo Buturi 74,12

      Pages: 1580-1583

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] ULTRA HIGH SENSITIVITY INSB MICRO-HALL BIOSENSOR SYSTEM FOR HIGH SPEED BIOSCREENING APPLICATIONS2004

    • Author(s)
      H.Sanbonsugi, M.Abe, A.Sandhu, H.Handa
    • Journal Title

      Proceedings of The Ninth International Conference on Ferrites (ICF-9)

      Pages: 419-424

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 特集バイオ・医療を志向する次世代の磁性微粒子<基礎編>医用磁性ナノビーズの新規作製技術2004

    • Author(s)
      阿部正紀, 半田宏
    • Journal Title

      バイオインダストリー 8

      Pages: 7-13

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] 医用磁性ナノビーズのポストゲノム解析時代における新展開2004

    • Author(s)
      阿部正紀, 半田宏
    • Journal Title

      日本応用磁気学会誌 28,7

      Pages: 841-846

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] High Sensitivity InSb Ultra-Thin+Film Micro-Hall Sensors for Bioscreening Applications2004

    • Author(s)
      Adarsh Sandhu, Hideaki Sanbonsugi, Ichiro Shibasaki, Masanori Abe, Hiroshi Handa
    • Journal Title

      Japanese J. Applied Physics No.7 A

      Pages: 868-870

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Synthesis of affinity nanoparticles coupled to FR901464 derivatives.2004

    • Author(s)
      Imamura, Y., Ohtsu, Y., Tanaka, H., Hatakeyama, M., Manabe, T., Kawaguchi, H., Handa, H., Takahashi, T.
    • Journal Title

      Heterocycles 64

      Pages: 51-56

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Synthesis of monodisperse ferrite nanoparticles coated with polyacrylic acid (PAA).2004

    • Author(s)
      Nishio, K., Hasegawa, M., Ikeda, M., Narimatsu, H., Hase, Y., Ogura, Y., Gokon, N., Tsubouchi, S., Hatakeyama, M., Abe, M., Handa, H.
    • Journal Title

      Trans. Mater. Res. Soc. Jpn. 29

      Pages: 1659-1662

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammtory bowel disease.2004

    • Author(s)
      Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T
    • Journal Title

      Gastroenterology 126

      Pages: 829-839

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Limited capability of regional lymph nodes to eradicate metastatic cancer cells.2004

    • Author(s)
      Nagata H, Arai T, Soejima Y, Suzuki H, Ishii H, Hibi T
    • Journal Title

      Cancer Res 64(22)

      Pages: 8239-8248

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] T-bet up-regulation and subsequent interleukin 12 stimulation are essential for the induction of Th1 mediated immunopathology in Crohn's disease.2004

    • Author(s)
      Matsuoka K, Inoue N, Sato T, Okamoto S, Hisamatsu T, Kishi Y, Sakuraba A, Hitotsumatsu O, Fukushima T, Kanai T, Watanabe M, Ishii H, Hibi T
    • Journal Title

      Gut 53

      Pages: 1303-1308

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal canders.2004

    • Author(s)
      Ezaki T, Watanabe M, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T
    • Journal Title

      Cancer Res 63

      Pages: 3747-3749

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] High Sensitivity InSb Ultra-Thin Film Micro-Hall Sensors for Bioscreening Applications2004

    • Author(s)
      Adarsh Sandhu, Hideaki Sanbonsugi, Ichiro Shibasaki, Masanori Abe, Hiroshi Handa
    • Journal Title

      Japanese J.Applied Physics No.7A

      Pages: 868-870

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Synthesis of monodisperse ferrite nanoparticles coated with polyacrylic acid (PAA).2004

    • Author(s)
      Nishio, K., Hasegawa, M., Ikeda, M., Narimatsu, H., Hase, Y., Ogura., Y, Gokon, N., Tsubouchi, S., Hatakeyama, M., Abe, M., Handa, H.
    • Journal Title

      Trans.Mater.Res.Soc.Jpn. 29

      Pages: 1659-1662

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Hyperexpression of inducible costimulator and its contribution on lamina propria T cells in inflammatory bowel disease.2004

    • Author(s)
      Sato T, Kanai T, Watanabe M, Sakuraba A, Okamoto S, Nakai T, Okazawa A, Inoue N, Totsuka T, Yamazaki M, Kroczek RA, Fukushima T, Ishii H, Hibi T
    • Journal Title

      Gastroenterology 126

      Pages: 829-839

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Limited capability of regional lymph nodes to eradicate metastatic cancer cells.2004

    • Author(s)
      Nagata H, Arai T, Soejima Y, Suzuki H, Ishii H, Hibi T
    • Journal Title

      Cancer Res. 64(22)

      Pages: 8239-8248

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] T-bet up-regulation and subsequent interleukin 12 stimulation are essential for the induction of Th1 mediated immunopathology in Crohn's disease2004

    • Author(s)
      Matsuoka K, Inoue N, Sato T, Okamoto S, Hisamatsu T, Kishi Y, Sakuraba A, Hitotsumatsu O, Fukushima T, Kanai T, Watanabe M, Ishii H, Hibi T
    • Journal Title

      Gut 53

      Pages: 1303-1308

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A specific genetic alteration on chromosome 6 in ulcerative colitis-associated colorectal cancers.2004

    • Author(s)
      Ezaki T, Watanabe M, Kanai T, Ogata H, Iwao Y, Ishii H, Hibi T
    • Journal Title

      Cancer Res. 63

      Pages: 3747-3749

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel Techniques for Fabricating Magnetic Nanobeads2004

    • Author(s)
      Abe, M., Handa, H.
    • Journal Title

      Bio Industry 8

      Pages: 7-13

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Prospects for Medical Applications Using Magnetic Beads in the Post-Genomic Era2004

    • Author(s)
      Abe, M., Handa, H.
    • Journal Title

      J.Mag.Soc.Jpn 28,7

      Pages: 841-846

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Direct immobilization of fluorescent dyes onto ferrite nanoparticles during their synthesis from aqueous solution2003

    • Author(s)
      S.Hatanaka, N.Matsushita, M.Abe, K.Nishimura, M.Hasegawa, H.Handa
    • Journal Title

      J. Appl. Phys 93, 10

      Pages: 7569-7570

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Method for synthesizing ferrite nanoparticles 〜30 nm in diameter on neutral pH condition for biomedical applications2003

    • Author(s)
      M.Tada, S.Hatanaka, H.Sanbonsugi, N.Matsushita, M.Abe
    • Journal Title

      J. Appl. Phys 93, 10

      Pages: 7566-7568

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Direct immobilization of fluorescent dyes onto ferrite nanoparticles during their synthesis from aqueous solution2003

    • Author(s)
      S.Hatanaka, N.Matsushita, M.Abe, K.Nishimura, M.Hasegawa, H.Handa
    • Journal Title

      J.Appl.Phys 93,10

      Pages: 7569-7570

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Method for synthesizing ferrite nanoparticles 〜30 nm in diameter on neutral pH condition for biomedical applications2003

    • Author(s)
      M.Tada, S.Hatanaka, H.Sanbonsugi, N.Matsushita, M.Abe
    • Journal Title

      J.Appl.Phys 93,10

      Pages: 7566-7568

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel Ferrite Films and Fine Particles Prepared at 3〜 100℃ by a Soft Solution Processing and Their Applications2003

    • Author(s)
      Masanori Abe
    • Journal Title

      CIMTEC 2002- 10th International Ceramics Congress and 3rd Forum on New Materials, (Florence, Italy, July, 14-19, 2002)

      Pages: 501-510

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Development of affinity-purification technology for identification of drug receptors.2003

    • Author(s)
      Hasegawa, M., Uga, H., Ohba, R., Tsuboi, Y., Sato, I., Tang, J., Kabe, Y., Handa, H.
    • Journal Title

      Recent Res.Develp.Biophys.Biochem. 3

      Pages: 445-456

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Microwave and Nano-biomagnetic Applications of Ferrite Thin Films and Fine Particles Prepared from an Aqueous Solution2003

    • Author(s)
      Abe, M., Handa, H.
    • Journal Title

      J.Mag.Soc.Jpn 27,6

      Pages: 721-729

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Novel Ferrite Films and Fine Particles Prepared at 3〜100℃ by a Soft Solution Processing and Their Applications2002

    • Author(s)
      Masanori Abe
    • Journal Title

      CIMTEC 2003 - 10th International Ceramics Congress and 3rd Forum on New Materials, (Florence, Italy, July 14-19, 2002)

      Pages: 501-510

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Detection of magnetically labeled DNA using pseudomorphic ALGaAs/InGaAs/GaAs heterostructure micro-Hall biosensor.

    • Author(s)
      Togawa, K., Sanbonsugi, H., Sandhu, A., Narimatsu, H., Nishio, K., Handa, H.
    • Journal Title

      J. Appl. Phys. (In press)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Detection of magnetically labeled DNA using pseudomorphic AlGaAs/InGaAs/GaAs heterostructure micro-Hall biosensor

    • Author(s)
      Togawa, K., Sanbonsugi, H., Sandhu, A., Narimatsu, H., Nishio, K., Handa, H.
    • Journal Title

      J.Appl.Phys. (In press)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 遺伝子医学M00K5号 ナノ磁性微粒子による遺伝子導入法2006

    • Author(s)
      野村祥太郎, 望月勇輔, 西尾広介, 阪本聡, 半田宏(分担)
    • Total Pages
      6
    • Publisher
      株式会社メディカル ドゥ
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 4,2 MRイメージング用ナノ磁性ビーズ、医療機器と再生医療 -開発最前線と今後の同港-2005

    • Author(s)
      阿部正紀, 半田宏(分担)
    • Total Pages
      11
    • Publisher
      情報機構
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 14,医用・磁性ナノビーズ ナノ粒子の製造・評価・応用・機器の最新技術2002

    • Author(s)
      阿部正紀, 半田宏(分担)
    • Total Pages
      4
    • Publisher
      シーエムシー出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Book] 磁性ビーズのバイオ・環境技術への応用展開

    • Author(s)
      半田宏, 阿部正紀, 野田紘喜(監修)
    • Publisher
      シーエムシー出版
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] 磁気ビーズセパレータ2005

    • Inventor(s)
      阿部正紀, 多田大, 嶋津隆一
    • Industrial Property Rights Holder
      東京工業大学
    • Industrial Property Number
      特許、2005-106564(出願番号)
    • Filing Date
      2005-04-01
    • Description
      「研究成果報告書概要(和文)」より
  • [Patent(Industrial Property Rights)] ポリマー被覆微粒子の製造方法およびポリマー被覆微粒子2004

    • Inventor(s)
      半田宏, 阿部正紀, 郷右近展之, 壷内信吾, 畠山士, 西尾広介, 池田森人, 成松宏樹
    • Industrial Property Rights Holder
      財団法人理工学振興会
    • Industrial Property Number
      特許、2004-363638
    • Filing Date
      2004-12-15
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2007-12-13  

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