• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2005 Fiscal Year Final Research Report Summary

Feed back and feed forward control of brain function by the deep brain stimulation system.

Research Project

Project/Area Number 15209047
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Cerebral neurosurgery
Research InstitutionNihon University

Principal Investigator

KATAYAMA Yoichi  Nihon Univ. School of Medicine, Professor, Dept., 医学部, 教授 (00125048)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Takamitsu  Nihon Univ. School of Medicine, Professor, Dept., 医学部, 教授 (50158284)
SAKATANI Kaoru  Nihon Univ. School of Medicine, Professor, Dept., 医学部, 教授 (90244350)
SEKINE Yoshifumi  Nihon Univ. College of Science and Technology, Prof., 理工学部, 教授 (90059965)
Project Period (FY) 2003 – 2005
Keywordsdeep brain stimulation / spinal cord stimulation / motor cortex stimulation / feed back control / feed forward control / brain computer interface / brain machine interface / pain
Research Abstract

Deep brain stimulation (DBS) of the thalamus (Vo/Vim) has become popular as a means of controlling involuntary movements, including post-stroke movement disorders. We have also found that post-stroke movement disorders and motor weakness can sometimes be controlled by motor cortex stimulation (MCS). In some forms of movement disorders, motor dysfunction becomes evident only when patients intend to move their body. We have developed an on-demand type stimulation system which triggers stimulation by detecting intrinsic signals of intention to move. Such a system represents feed-forward control (FFC) of involuntary movements. We report here our experience of DBS and MCS for controlling post-stroke movement disorders, and discuss the value of FFC. Excellent control of post-stroke movement disorders was achieved by conventional DBS and/or MCS in 20 of 28 patients with hemichoreoathetosis, hemiballism tremor and motor weakness. FFC was tested in 6 patients who demonstrated excellent control of post-stroke postural tremor or motor weakness by conventional DBS or MCS. The on-demand stimulation provided satisfactory FFC in 4 of 4 patients with postural tremor and 2 of 2 patients with motor weakness, when the activity of muscles involved in posturing or intention to move was fed into the system. These findings justify further clinical studies on DBS and MCS in patients with post-stroke movement disorders. The on-demand type stimulation system may also be useful for overcoming various post-stroke movement disorders.

  • Research Products

    (15 results)

All 2006

All Journal Article (14 results) Book (1 results)

  • [Journal Article] Direct effect of subthalamic nucleus stimulation on levodopa-induced peak-dose dyskinesia in patients with Parkinson disease2006

    • Author(s)
      Katayama Y
    • Journal Title

      Stereotactic and Functional Neurosurgery 84

      Pages: 176-179

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Feed-forward control of post-stroke movement disorders by on-demand type stimulation of the thalamus and motor cortex.2006

    • Author(s)
      Katayama Y
    • Journal Title

      Acta Neurochirurgica Suppl. 99

      Pages: 21-23

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Thalamic sensory relay nucleus stimulation for the treatment of peripheral deafferentation pain.2006

    • Author(s)
      Yamamoto T
    • Journal Title

      Stereotactic and Functional Neurosurgery 84

      Pages: 180-183

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Changes of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy.2006

    • Author(s)
      Sakatani K
    • Journal Title

      Life Science 78

      Pages: 2734-2741

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Effects of cerebral ischemia on evoked cerebral blood oxygenation response and BOLD contrast functional MRI in stroke patient.2006

    • Author(s)
      Murata Y
    • Journal Title

      Stroke 37

      Pages: 2514-2520

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Chcnages of cerebral blood oxygenation and optical pathlength during activation and deactivation in the prefrontal cortex measured by time-resolved near infrared spectroscopy.2006

    • Author(s)
      Sakatani K, Yamashita D, Yamanaka T, Oda M, Yamashita Y, Hoshino T, Fujiwara N, Murata Y, Katayama Y
    • Journal Title

      Life Sciences 78

      Pages: 2734-2741

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Direct effect of subthalamic nucleus stimulation on levodopa-induced peak-dose dyskinesia in patients with Parkinson's disease.2006

    • Author(s)
      Katayama Y, Oshima H, Kano T, Kobayashi K, Fukaya C, Yamamoto T
    • Journal Title

      Stereotactic and Functional Neurosurgery 84

      Pages: 176-179

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Thalamic sensory relay nucleus stimulation for the treatment of peripheral deafferentation pain.2006

    • Author(s)
      Yamamoto T, Katayama Y, Obuchi T, Kano T, Kobayashi K, Oshima H, Fukaya C
    • Journal Title

      Stereotactic and Functional Neurosurgery 84

      Pages: 180-183

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Intraoperative monitoring of cerebral blood oxygenation and hemodynamics during extracranial-intracranial bypass surgery by a newly developed visible light spectroscopy system.2006

    • Author(s)
      Hoshino T, Katayama Y, Sakatani K, Kano T, Murata Y
    • Journal Title

      Surgical Neurology 65

      Pages: 569-576

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Cerebral blood oxygenation changes induced by bypass blood flow in moyamoya disease and non-moyamoya cerebral ischemic disease.2006

    • Author(s)
      Hoshino T, Sakatani K, Kano T, Murata Y, Katayama Y
    • Journal Title

      Acta Neurochirurgica 148

      Pages: 551-557

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Effects of cerebral ischemia on evoked cerebral blood oxygenation responses and BOLD contrast finctional MRI in stroke patients.2006

    • Author(s)
      Murata Y, Sakatani K, Hoshino T, Fujiwara M, Kano T, Nakamura S, Katayama Y
    • Journal Title

      Stroke 37

      Pages: 2514-2520

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Feed-forward control of post-stroke movement disorders by on-demand type stimulation of the thalamus and motor cortex.2006

    • Author(s)
      Katayama Y, Kano T, Kobayashi K, Oshima H, Fukaya C, Yamamoto T
    • Journal Title

      Acta Neurochirurgica suppl 99

      Pages: 21-23

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Pallidal high-frequency deep brain stimulation for camptocormia. An experience of three cases.2006

    • Author(s)
      Fukaya C, Otaka T, Obuchi T, Kano T, Nagaoka T, Kobayashi K, Oshima H, Yamamoto T, Katayama Y
    • Journal Title

      Acta Neurochirurgica suppl 99

      Pages: 25-28

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Detection of boundaries of subthalamic nucleus by multiple-cell spike density analysis in deep brain stimulation for Parkinson's disease.2006

    • Author(s)
      Kano T, Katayama Y, Kobayashi K, Kasai M, Oshima H, Fukaya C, Yamamoto T
    • Journal Title

      Acta Neurochirurgica suppl 99

      Pages: 25-28

    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 痛み研究のアプローチ2006

    • Author(s)
      山本隆充
    • Total Pages
      187-193
    • Publisher
      新興交易医書出版部(分担執筆)
    • Description
      「研究成果報告書概要(和文)」より

URL: 

Published: 2008-05-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi