2005 Fiscal Year Final Research Report Summary
Artificial Vision by Stimulation of Optic Nerve by Electrodes Implanted in Optic Disc
| Project/Area Number |
15209056
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
TANO Yasuo Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (80093433)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIKADO Takashi Osaka University, Graduate School of Medicine, Professor, 医学系研究科, 教授 (50243233)
YAGI Tetsuya Osaka University, Graduate School of Engineering, Professor, 工学研究科, 教授 (50183976)
OHJI Masahito Shiga University of Medical Science, Professor, 医学部, 教授 (90252650)
KAMEI Motohiro Osaka University, Graduate School of Medicine, Associate Professor, 医学系研究科, 助教授 (40281125)
MIYOSHI Tomomitu Osaka University, Graduate School of Medicine, Assistant, 医学系研究科, 助手 (70314309)
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| Project Period (FY) |
2003 – 2005
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| Keywords | Electrically evoked potential / Electrical stimulation / Electrode / Optic nerve / Visual prosthesis / Artificial Vision / パリレン / PDGF |
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| Research Abstract |
Purpose : To determine the safety and efficacy of transsclerally placed intrapapillary wire microelectrodes implanted chronically into the optic nerve head.
Methods : Platinum wire microelectrodes were passed through the sclera and implanted into the optic nerve head of five rabbit eyes for 4-6 months. Color fundus photography, fluorescein angiography, electroretinograms (ERGs), and visually evoked potentials (VEPs) were used to monitor the retina. Electrically evoked potentials (EEPs) were elicited by bipolar electrical stimulation of the optic nerve axons by different combinations of the four electrodes immediately after the implantation and at 1-month intervals thereafter. The effects of the chronic implantation of the electrodes on the morphology of the optic nerve were evaluated by histological and immunohistochemical examinations at 4 and 6 months after the implantation.
Results : All of the electrodes remained stable in the implanted sites throughout the post-implantation period,
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except for one electrode that had pulled out of the optic nerve head at 1 month after implantation. No intraocular infection, inflammation, or vitreoretinal proliferation was observed in any eye. EEPs could be elicited from each pair of electrodes at all testing times. The mean threshold currents (charge densities) to evoke EEPs increased at 1 month after implantation, but did not change significantly thereafter. The implicit time and amplitude of the a- and b-waves of the ERGs and of P1 of the VEPs did not change significantly throughout the post-implantation period. Histological evaluation of the optic nerve head revealed slight tissue encapsulations surrounding the electrode and increased expression of glial fibrillary acidic protein near the surface of the optic nerve.
Conclusions : Implantation of transscleral intrapapillary microelectrodes appears to be safe and effective. These findings indicate that the implantation of microelectrodes in the optic nerve head should be considered for an optic nerve-based prosthesis. Less
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[Journal Article] Direct stimulation of optic nerve by electrodes implanted in optic disc of rabbit eyes.2005
Author(s)
Fang X, Sakaguchi H, Fujikado T, Osanai M, Kanda H, Ikuno Y, Kamei M, Ohji M, Gan D, Choi J, Yagi T, Tano Y.
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Journal Title
Graefes Arch Clin Exp Ophthalmol. 243(1)
Pages: 49-56
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] 「研究成果報告書概要(欧文)」より2005
Author(s)
Nakauchi K, Fujikado T, Kanda H, Morimoto T, Choi JS, Ikuno Y, Sakaguchi H, Kamei M, Ohji M, Yagi T, Nishimura S, Sawai H, Fukuda Y, Tano Y.
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Journal Title
Graefes Arch Clin Exp Ophthalmol. 243(2)
Pages: 169-174
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[Journal Article] Electrical stimulation with a needle-type electrode inserted into the optic nerve in rabbit eyes.2004
Author(s)
Sakaguchi H, Fujikado T, Kanda H, Osanai M, Fang X, Nakauchi K, Ikuno Y, Kamei M, Ohji M, Yagi T, Tano Y.
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Journal Title
Jpn J Ophthalmol. 48(6)
Pages: 552-557
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Transretinal electrical stimulation with a suprachoroidal multichannel electrode in rabbit eyes.2004
Author(s)
Sakaguchi H, Fujikado T, Fang X, Kanda H, Osanai M, Nakauchi K, Ikuno Y, Kamei M, Yagi T, Nishimura S, Ohji M, Yagi T, Tano Y.
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Journal Title
Jpn J Ophthalmol. 48(3)
Pages: 256-261
Description
「研究成果報告書概要(欧文)」より
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[Book] Brain Repair2005
Author(s)
Miyoshi T, et al.
Total Pages
15
Publisher
Landes Bioscience
Description
「研究成果報告書概要(和文)」より
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