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2005 Fiscal Year Final Research Report Summary

Molecular Epidemiological Study of Thyroid Disease in Radiation Contaminated Area

Research Project

Project/Area Number 15256004
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Endocrinology
Research InstitutionNagasaki University

Principal Investigator

NAMBA Hiroyuki  Nagasaki University, Graduate School of Biomedical Sciences, A/Professor, 大学院・医歯薬学総合研究科, 助教授 (80237635)

Co-Investigator(Kenkyū-buntansha) OHTSURU Akira  Nagasaki University, Hospital of Medicine and Dentistry, A/Professor, 医学部・歯学部附属病院, 助教授 (00233198)
ASHIZAWAI Kiyoto  Nagasaki University, Radiation Effects Research Foundation, Research Scientist, 臨床部門, 研究員 (10304932)
TAKAMURA Noboru  Nagasaki University, Graduate School of Biomedical Sciences, A/Professor, 大学院・医歯薬学総合研究科, 助教授 (30295068)
AOYAGI Kiyoshi  Nagasaki University, Graduate School of Biomedical Sciences, Professor, 大学院・医歯薬学総合研究科, 教授 (80295071)
Project Period (FY) 2003 – 2005
KeywordsRadiation / Thyroid cancer / International Medical Care / Molecular Epidemiology / Chernobyl / Tissue Bank / Semipalatinsk / e-Learning
Research Abstract

In this study, our group is participating in International Chernobyl Tissue Bank Project, which stocks and manages nuclear acids extracted from Chernobyl childhood thyroid cancer tissues for research purpose. We collaborate international medical care with Medical Radiological Research Centre, Russian Academy of Medical Sciences (Russian Federation), Belarusian Medical University (Republic of Belarus), Research Center for Radiation Medicine of the Academy of Medical Sciences of Ukraine (Ukraine) and Research Institute for Radiation Medicine and Ecology (Republic of Kazakhstan). We accepted and trained 18 research scientists from these collaboration Universities and Institutes in our institute during last three years. We established telemedicine and teleeducation system between Gomel Medical University (Republic of Belarus) and our institute to give lectures to medical students in Gomel Medical University. Our group also visited Gomel and Minsk for three weeks every year to take the helm on molecular epidemiological study and e-Learning system. We analyzed mitochondria DNA and genomic DNA extracted from Chernobyl childhood thyroid cancer tissues to find radiation signatures left in the DNA. As the results, we found large deletion of mitochondria DNA and unique SNPs sites in DNA repair related genes including TP53, ATM and MDM2 genes in radiation associated thyroid cancers. Through this study, we found new findings of radiation associated thyroid cancer and promoted international exchanges regarding scientific research and educations. We hope further extending studies in this field.

  • Research Products

    (40 results)

All 2006 2005 2004 2003

All Journal Article (40 results)

  • [Journal Article] Inhibition of ABL tyrosine kinase potentiates radiation-induced terminal growth arrest in anaplastic thyroid cancer cells.2006

    • Author(s)
      Podtcheko A, et al.
    • Journal Title

      Radiation Research 165・1

      Pages: 35-42

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Selective pharmacologic inhibition of c-Jun NH2-terminal kinase radiosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest.2006

    • Author(s)
      Bulgin D, et al.
    • Journal Title

      Thyroid 16・3

      Pages: 217-224

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in Hiroshima and Nagasaki atomic bomb survivors 55-58 years after radiation exposure.2006

    • Author(s)
      Imaizumi M, et al.
    • Journal Title

      The Journal of the American Medical Association 295・9

      Pages: 1011-1022

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] TP53 codon72 polymorphism in radiation-associated human papillary thyroid cancer.2006

    • Author(s)
      Rogounovitch TI, et al.
    • Journal Title

      Oncology Reports 15・4(印刷中)

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Selective pharmacologic inhibition of c-Jun NH2-terminal kinase rediosensitizes thyroid anaplastic cancer cell lines via induction of terminal growth arrest.2006

    • Author(s)
      Bulgin D, et al.
    • Journal Title

      Thyroid 16・3

      Pages: 217-224

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Radiation dose-response relationships for thyroid nodules and autoimmune thyroid diseases in Hiroshima and Nagasaki atomic bomb survivors 55-58 years after radiation exposure.2006

    • Author(s)
      Imaizumi M, et al.
    • Journal Title

      The Journal of the American Medical Association 295・9

      Pages: 1011-1022

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] TP53 codon 72 polymorphism in radiation-associated human papillary thyroid cancer.2006

    • Author(s)
      Rogounovitch TI, et al.
    • Journal Title

      Oncology Reports 15・4

      Pages: 949-956

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Diagnostic usefulness of PCR profiling of the differentially expressed marker genes in thyroid papillary carcinomas.2005

    • Author(s)
      Hamada A, et al.
    • Journal Title

      Cancer Letters 224・2

      Pages: 289-301

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Radiation-induced senescence-like terminal growth arrest in thyroid cells.2005

    • Author(s)
      Podtcheko A, et al.
    • Journal Title

      Thyroid 15・4

      Pages: 306-313

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cyclin D1 overexpression in thyroid papillary microcarcinoma : its association with tumour size and aberrant beta-catenin expression.2005

    • Author(s)
      Kantsov D, et al.
    • Journal Title

      Histopathology 47・3

      Pages: 248-256

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Vitamin D3 treatment for locally advance thyroid cancer : a case report.2005

    • Author(s)
      Marichita M, et al.
    • Journal Title

      Endocrine Journal 52・5

      Pages: 613-616

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Measurement of the whole-body 137Cs in residents around the Chernobyl unclear power plant.2005

    • Author(s)
      Morita N, et al.
    • Journal Title

      Radiation Protection Dosimetry 113・3

      Pages: 326-329

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Long-term prognosis of thyroid nodule cases compared with nodule-free controls in atomic bomb survivors.2005

    • Author(s)
      Imaizumi M, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 90・9

      Pages: 5009-504

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cyclin D1 overexpression in thyroid papillary microcarncinoma : its association with tumour size and aberrant beta-catenin expression.2005

    • Author(s)
      Lantsov D, et al.
    • Journal Title

      Histopathology 47・3

      Pages: 248-256

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Vitamin D3 treatment for locally advanced thyroid cancer : a case report.2005

    • Author(s)
      Morishita M, et al.
    • Journal Title

      Endocrine Journal 52・5

      Pages: 613-616

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Measurement of the whole-body 137Cs in residents around Chernobyl nuclear power plant.2005

    • Author(s)
      Morita N, et al.
    • Journal Title

      Radiation Protection Dosimetry 113・3

      Pages: 326-329

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Long-term prognosis of thyroid nodule cases compared with nodule-free controls in atomic bomb survivors.2005

    • Author(s)
      Imaizumi, M, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 90・9

      Pages: 5009-5014

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Inhibition of nuclear factor-kappaB cascade potentiates the effect of a combination treatment of anaplastic thyroid cancer cells.2004

    • Author(s)
      Starenki D, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 89・1

      Pages: 410-418

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular mechanisms of the effects of low concentrations of Taxol in anaplastic thyroid cancer cells.2004

    • Author(s)
      Pushkaerv VM, et al.
    • Journal Title

      Endocrinology 145・7

      Pages: 3143-3152

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] No increase of large-scale mitochondrial DNA deletions in peripheral blood cells in residents of Kazakhstan around Semipalatinsk nuclear test site.2004

    • Author(s)
      Hamada A, et al.
    • Journal Title

      Act Medica Nagasakiensia 49

      Pages: 45-49

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Cyclin D1 overexpression in thyroid tumours from a radio-contaminated area and its correlation with Pin1 and aberrant beta-catenin expression.2004

    • Author(s)
      Nakashima M, et al.
    • Journal Title

      Journal of Pathology 202・4

      Pages: 446-455

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Risk for ischemic heart disease and all-cause mortality in subclinical hypothyroidism.2004

    • Author(s)
      Imaizumi M, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 89・7

      Pages: 3365-3370

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas.2004

    • Author(s)
      Kumagai A, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 89・9

      Pages: 4280-4284

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin.2004

    • Author(s)
      Starenki DV, et al.
    • Journal Title

      Clinical Cancer Research 10・20

      Pages: 6821-6829

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] The BRAFT1796A transversion is a prevalent mutational event in human thyroid microcarcinoma.2004

    • Author(s)
      Sedliarou I, et al.
    • Journal Title

      International Journal of Oncology 25・6

      Pages: 1729-1735

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] A rapid and simple detection method for the BRAFT1796A mutation in fine-needle aspirated thyroid carcinoma cells.2004

    • Author(s)
      Hayashida N, et al.
    • Journal Title

      Thyroid 14・11

      Pages: 910-915

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Thyroid blockade during a radiation emergency in iodine-rich areas : effect of a stable-iodine dosage.2004

    • Author(s)
      Takamura N, et al.
    • Journal Title

      Journal of Radiation Research 45・2

      Pages: 201-204

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Molecular mechanisms of the effects of low concentrations of Taxol in anaplastic thyroid cancer cells.2004

    • Author(s)
      Pushkarev VM, et al.
    • Journal Title

      Endocrinology 145・7

      Pages: 3143-3152

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] No increase of large-scale mitochondrial DNA deletions in peripheral blood cells in residents of Kazakhstan around Semipalatinsk nuclear test site.2004

    • Author(s)
      Hamada A, et al.
    • Journal Title

      Acta Medica Nagasakiensia 49

      Pages: 45-49

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Induction of thyroid cancer cell apoptosis by a novel nuclear factor kappaB inhibitor, dehydroxymethylepoxyquinomicin.2004

    • Author(s)
      Starenki D, et al.
    • Journal Title

      Clinical Cancer Research 10・20

      Pages: 6821-6829

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] The Selective tyrosine kinase inhibitor, STI571, inhibits growth of anaplastic thyroid cancer cells.2003

    • Author(s)
      Podtcheko A, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 88・4

      Pages: 1889-1896

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel tumorigenic rearrangement, delta-rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.2003

    • Author(s)
      Saeko V, et al.
    • Journal Title

      Mutation Research 527

      Pages: 81-90

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Clinical implication of Hot Spot BRAF Mutation, V599E, in papillary thyroid cancers.2003

    • Author(s)
      Namba H, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 88・9

      Pages: 4393-4397

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Authors' Response : Effect of imatinib mesylate (gleevec) on anaplastic thyroid carcinoma cell lines.2003

    • Author(s)
      Podtcheko A, et al.
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism 88・10

      Pages: 5044

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Correlation of cytoplasmic beta-catenin and cyclin D1 overexpression during thyroid carcinogenesis around Semipalatinsk nuclear test site.2003

    • Author(s)
      Meirmanov S, et al.
    • Journal Title

      Thyroid 13・6

      Pages: 537-545

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] No evidence of radiation risk for thyroid gland among schoolchildren around Semipalatinsk nuclear testing site.2003

    • Author(s)
      Hamaa A, et al.
    • Journal Title

      Endocrine Journal 50・1

      Pages: 85-89

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Urinary iodine kinetics after oral loading of potassium iodine.2003

    • Author(s)
      Takaura N, et al.
    • Journal Title

      Endocrine Journal 50・5

      Pages: 589-593

    • Description
      「研究成果報告書概要(和文)」より
  • [Journal Article] Novel tumorigenic rearrangement, delta-rfp/ret, in a papillary thyroid carcinoma from externally irradiated patient.2003

    • Author(s)
      Saenko V, et al.
    • Journal Title

      Mutation Research 527

      Pages: 81-90

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] No evidence of radiation risk for thyroid gland among schoolchildren around Semipalatinsk nuclear tasting site.2003

    • Author(s)
      Hamada A, et al.
    • Journal Title

      Endocrine Journal 50・1

      Pages: 85-89

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Urinary iodine kinetics after oral loading of potassium iodine.2003

    • Author(s)
      Takamura N, et al.
    • Journal Title

      Endocrine Journal 50・5

      Pages: 589-593

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2007-12-13  

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